Africa is rich in both natural and human resources, yet nearly 200 million of its people are undernourished because of inadequate food supplies. Comprehensive strategies are needed across the continent to harness the power of science and technology (S&T) in ways that boost agricultural productivity, profitability, and sustainability -- ultimately ensuring that all Africans have access to enough safe and nutritious food to meet their dietary needs. This report addresses the question of how science and technology can be mobilized to make that promise a reality.