Evolution Oriented Genome Personalised
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| Author | : Hani K. RIZK |
| Publisher | : Hani K. RIZK |
| Total Pages | : 461 |
| Release | : 2017-10-01 |
| Genre | : Science |
| ISBN | : 9933360078 |
ABOUT THE BOOK The Book is an interdisciplinary textbook, written with the intent of introducing two new concepts. A. The Association Constant (Ka) versus Entropy and Chaos. 1. The formation and evolution of chemical and biological compounds on atomic and molecular scales are the work of the four natural forces, enhanced by the existence of the natural constants and their remarkable adjustment. And the work of the covalent and noncovalent forces (bonds) being derived from the natural forces. So is the evolution of living organisms but with the essential and indispensable impact of the environment, violent and punctuate. 2. The effects of the natural forces (through the covalent and noncovalent bonds) is expressed by Ka. Therefore, Ka preserves what nature accomplishes by protecting matter against the action of entropy (a faulty distribution of matter), and by preserving free energy (-ΔG) against the action of chaos (a faulty distribution of energy). Evolution is an obligation to elegance and wisdom. 3. The Book draws straight and clear line connecting general relativity, i.e. gravity (the infinite large), quantum mechanics (the infinite small), and biology (the infinite complex). B. Individuality of the Human Genome. 1. Our uniqueness as species (Homo sapiens) is invariantly encoded in the protein-coding genes (about 2 percent of our DNA). These genes are invariably found in every human being. They are species - specific, responsible for the human genesis and form the human genophenotype. Our uniqueness as individuals variantly resides in the rest of our DNA (the nonprotein-coding DNA, about 98 percent of our genome) and in the histones (chemical modifications and compaction of nucleosomes). They constitute the epigenetic factors responsible for the formation of the epigenetic phenotype, which is variably different from one individual to another. They are individual - specific. Epigenetic factors variantly effect and regulate gene expression. For example, the craniofacial structure in mice is encoded in 300 protein-coding genes. The expression of these genes is regulated by 4000 different sequences of nonprotein-coding DNA called enhancers. Thus, the number of different forms of the craniofacial structure that might develop in mice is 300 exponentiated 4000 epiphenotypes. Other than enhancers, there are the mobile elements of DNA, dsRNA-coding DNA, chemical modification of DNA (e.g., methylation), and so forth. 2. Mind exclusively exists in man as an emergent phenomenon. 3. All scientific data presented in the Book are entirely intended to reflect, to explain, or to prove the Two Concepts rather than to discuss their significances and originalities. The interdisciplinarity of the Book offers a unique opportunity for understanding how astrophysics, quantum mechanics, thermodynamics, and biology are interrelated. Hani K. Rizk
| Author | : David N. Cooper |
| Publisher | : Taylor & Francis |
| Total Pages | : 412 |
| Release | : 1995 |
| Genre | : Science |
| ISBN | : 9781859960554 |
Within the last decade, much progress has been made in the analysis and diagnosis of human inherited disease, and in the characterization of the underlying genes and their associated pathological lesions.
| Author | : Rui Diogo |
| Publisher | : Springer |
| Total Pages | : 260 |
| Release | : 2017-03-08 |
| Genre | : Science |
| ISBN | : 3319475819 |
This book proposes a new way to think about evolution. The author carefully brings together evidence from diverse fields of science. In the process, he bridges the gaps between many different--and usually seen as conflicting--ideas to present one integrative theory named ONCE, which stands for Organic Nonoptimal Constrained Evolution. The author argues that evolution is mainly driven by the behavioral choices and persistence of organisms themselves, in a process in which Darwinian natural selection is mainly a secondary--but still crucial--evolutionary player. Within ONCE, evolution is therefore generally made of mistakes and mismatches and trial-and-error situations, and is not a process where organisms engage in an incessant, suffocating struggle in which they can't thrive if they are not optimally adapted to their habitats and the external environment. Therefore, this unifying view incorporates a more comprehensive view of the diversity and complexity of life by stressing that organisms are not merely passive evolutionary players under the rule of external factors. This insightful and well-reasoned argument is based on numerous fascinating case studies from a wide range of organisms, including bacteria, plants, insects and diverse examples from the evolution of our own species. The book has an appeal to researchers, students, teachers, and those with an interest in the history and philosophy of science, as well as to the broader public, as it brings life back into biology by emphasizing that organisms, including humans, are the key active players in evolution and thus in the future of life on this wonderful planet.
| Author | : Bruce R. Korf |
| Publisher | : John Wiley & Sons |
| Total Pages | : 280 |
| Release | : 2012-11-19 |
| Genre | : Medical |
| ISBN | : 1118537661 |
This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice 'Hot topics' boxes that focus on the latest developments in testing, assessment and treatment 'Ethical issues' boxes to prompt further thought and discussion on the implications of genetic developments 'Sources of information' boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.
| Author | : Bairong Shen |
| Publisher | : Springer |
| Total Pages | : 165 |
| Release | : 2017-10-20 |
| Genre | : Science |
| ISBN | : 981106041X |
The book addresses the interplay of healthcare and big data management. Thanks to major advances in big data technologies and precision medicine, healthcare is now becoming the new frontier for both scientific research and economic development. This volume covers a range of aspects, including: big data management for healthcare; physiological and gut microbiota – data collection and analysis; big data standardization and ontology; and personal data privacy and systems level modeling in the healthcare context. The book offers a valuable resource for biomedical informaticians, clinicians, health practitioners and researchers alike.
| Author | : Debmalya Barh |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 825 |
| Release | : 2013-10-14 |
| Genre | : Medical |
| ISBN | : 8132211847 |
“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.
| Author | : David A. Baum |
| Publisher | : Princeton University Press |
| Total Pages | : 886 |
| Release | : 2017-03-21 |
| Genre | : Science |
| ISBN | : 069117587X |
The essential one-volume reference to evolution The Princeton Guide to Evolution is a comprehensive, concise, and authoritative reference to the major subjects and key concepts in evolutionary biology, from genes to mass extinctions. Edited by a distinguished team of evolutionary biologists, with contributions from leading researchers, the guide contains some 100 clear, accurate, and up-to-date articles on the most important topics in seven major areas: phylogenetics and the history of life; selection and adaptation; evolutionary processes; genes, genomes, and phenotypes; speciation and macroevolution; evolution of behavior, society, and humans; and evolution and modern society. Complete with more than 100 illustrations (including eight pages in color), glossaries of key terms, suggestions for further reading on each topic, and an index, this is an essential volume for undergraduate and graduate students, scientists in related fields, and anyone else with a serious interest in evolution. Explains key topics in some 100 concise and authoritative articles written by a team of leading evolutionary biologists Contains more than 100 illustrations, including eight pages in color Each article includes an outline, glossary, bibliography, and cross-references Covers phylogenetics and the history of life; selection and adaptation; evolutionary processes; genes, genomes, and phenotypes; speciation and macroevolution; evolution of behavior, society, and humans; and evolution and modern society
| Author | : Iain Crinson |
| Publisher | : Springer Nature |
| Total Pages | : 208 |
| Release | : 2021-03-02 |
| Genre | : Social Science |
| ISBN | : 9811595232 |
This textbook provides a comprehensive introduction to the interdisciplinary field of the Social Studies of Science and Technology (SSST). Over the past two decades, the biomedical sciences have transformed our understanding of the relationship between the social and natural worlds, while its ‘promissory visions’ are seen to offer extraordinary opportunities for economic and social development. But alongside these scientific innovations have emerged new, and frequently unanticipated social, political, bioethical, and legal dilemmas and challenges. This cutting-edge text explores ‘post-genomic’ developments in the field of pharmacogenomics and the prospects for a new ‘precision’ or personalised medicine; the potential of environmental epigenetics to reconfigure the boundaries of the social and natural worlds; the emergence of an array of ‘neuro-disciplines’, seeking to identify the neural basis of a whole range of social and economic behaviours; and the challenges of constructing a coherent and robust governance framework for the conduct of biomedical science research and innovation, responsive to the social and health needs of the whole population.
| Author | : Alan Grafen |
| Publisher | : Oxford University Press (UK) |
| Total Pages | : 298 |
| Release | : 2007 |
| Genre | : Biography & Autobiography |
| ISBN | : 0199214662 |
This sparkling collection explores the impact of Richard Dawkins as scientist, rationalist, and one of the most important thinkers alive today. Specially commissioned pieces by leading figures in science, philosophy, literature, and the media, such as Daniel C. Dennett, Matt Ridley, Steven Pinker, Philip Pullman, and the Bishop of Oxford, highlight the breadth and range of Dawkins' influence on modern science and culture, from the gene's eye view of evolution to his energetic engagement in public debates on science, rationalism, and religion. The volume includes personal reminiscences and critical debate as well as accessible discussions of science - it provides a stimulating tribute to a remarkable intellectual.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 142 |
| Release | : 2012-01-16 |
| Genre | : Medical |
| ISBN | : 0309222222 |
Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
