Chelation Therapy in the Treatment of Metal Intoxication

Chelation Therapy in the Treatment of Metal Intoxication
Author: Jan Aaseth
Publisher: Academic Press
Total Pages: 390
Release: 2016-04-18
Genre: Medical
ISBN: 0128030739

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). - Presents all the current findings on the potential for chelation as a therapy for metal intoxication - Presents practical guidelines for selecting the most appropriate chelating agent - Includes coverage on radionuclide exposure and metal storage diseases - Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Iron Chelation Therapy

Iron Chelation Therapy
Author: Chaim Hershko
Publisher: Taylor & Francis US
Total Pages: 290
Release: 2002
Genre: Medical
ISBN: 9780306467851

Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria.

Essentials of Inorganic Chemistry

Essentials of Inorganic Chemistry
Author: Katja A. Strohfeldt
Publisher: John Wiley & Sons
Total Pages: 290
Release: 2015-02-16
Genre: Science
ISBN: 0470665580

A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.

Hepatotoxicity

Hepatotoxicity
Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
Total Pages: 850
Release: 1999
Genre: Medical
ISBN: 9780781719520

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Handbook of Arsenic Toxicology

Handbook of Arsenic Toxicology
Author: Swaran Jeet Singh Flora
Publisher: Academic Press
Total Pages: 752
Release: 2014-12-26
Genre: Science
ISBN: 0124199550

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. - Brings together current findings on the effects of arsenic on the environment and human health - Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms - Provides all the information needed for effective risk assessment, prevention and countermeasure

Contemporary Practice in Clinical Chemistry

Contemporary Practice in Clinical Chemistry
Author: William Clarke
Publisher: Academic Press
Total Pages: 1070
Release: 2020-06-11
Genre: Science
ISBN: 0128158336

Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry. - Includes enhanced illustration and new and revised color figures - Provides improved self-assessment questions and end-of-chapter assessment questions

Forty Something Forever

Forty Something Forever
Author: Harold Brecher
Publisher: Health Savers Press
Total Pages: 377
Release: 1992-01-01
Genre: Health & Fitness
ISBN: 9780927839464

Handbook of Clinical Drug Data

Handbook of Clinical Drug Data
Author: Philip O. Anderson
Publisher: McGraw-Hill Medical Publishing
Total Pages: 1176
Release: 2002
Genre: Medical
ISBN:

This handbook, which in its early lustrous years served physicians, pharmacists, and pharmacy students, is unlike any other drug reference book in that it allows readers to compare and contrast various drugs within drug categories, thereby enabling them to make decisions on which drug to administer. All other drug reference books merely repeat the drug manufacturers' literature, with no analysis of that information. Nor are there any reports from the published literature concerning use and efficacy of the drugs listed. The clinical drug information with part II contains chapters on drug-induced diseases, drug interactions and interferences, drug use in special populations, immunization, medical emergencies, and nutrition support. There are also appendices that contain useful conversion factors, anthropometrics, and laboratory indices. Unique Features: Comprehensive comparison charts of drugs by class for easy clinical decision making Tables that help rapidly identify the cause of adverse drug effects in your patients Guides to the optimal choice of drugs in special populations, such as pregnant and breastfeeding women, renal disease, and dialysis The only referenced drug handbook--includes over 3,600 literature citations Tabbing guide for easy location of drug categories Extensive cross-referenced index that includes Canadian and British drug names

Lowboy

Lowboy
Author: John Wray
Publisher: Farrar, Straus and Giroux
Total Pages: 272
Release: 2009-03-03
Genre: Fiction
ISBN: 142991453X

Early one morning in New York City, Will Heller, a sixteen-yearold paranoid schizophrenic, gets on an uptown B train alone. Like most people he knows, Will believes the world is being destroyed by climate change; unlike most people, he's convinced he can do something about it. Unknown to his doctors, unknown to the police—unknown even to Violet Heller, his devoted mother—Will alone holds the key to the planet's salvation. To cool down the world, he has to cool down his own overheating body: to cool down his body, he has to find one willing girl. And he already has someone in mind. Lowboy, John Wray's third novel, tells the story of Will's fantastic and terrifying odyssey through the city's tunnels, back alleys, and streets in search of Emily Wallace, his one great hope, and of Violet Heller's desperate attempts to locate her son before psychosis claims him completely. She is joined by Ali Lateef, a missing-persons specialist, who gradually comes to discover that more is at stake than the recovery of a runaway teen: Violet—beautiful, enigmatic, and as profoundly at odds with the world as her son—harbors a secret that Lateef will discover at his own peril. Suspenseful and comic, devastating and hopeful by turns, Lowboy is a fearless exploration of youth, sex, and violence in contemporary America, seen through one boy's haunting and extraordinary vision.