Enhanzer Drug Delivery Technology
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| Author | : Prashant L. Pingale |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 432 |
| Release | : 2022-03-21 |
| Genre | : Science |
| ISBN | : 3110746891 |
Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.
| Author | : David W. Kang |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 106 |
| Release | : 2022-06-30 |
| Genre | : Medical |
| ISBN | : 3318070769 |
‘ENHANZE® drug delivery technology: Advancing subcutaneous drug delivery using recombinant human hyaluronidase PH20’ provides readers with in-depth information on the potential benefits and challenges of subcutaneous (SC) drug delivery, the biology of hyaluronan and hyaluronidases in the SC space, and a comprehensive overview on the history of hyaluronidases and the development of recombinant human hyaluronidase PH20 (rHuPH20). Current applications of rHuPH20 as well as approved biotherapeutics utilizing HuPH20-facilitated SC drug delivery are summarized, and the underlying non-clinical and clinical development approaches are introduced as a basis for future application to biologics in various disease areas. Table of Contents: • Introduction to subcutaneous drug delivery • Biology of hyaluronan and hyaluronidases in the subcutaneous space • History of hyaluronidases and development of rHuPH20 • The ENHANZE® platform: Clinical applications of a subcutaneous drug delivery technology • Application of ENHANZE® drug delivery technology: Development of currently marketed products
| Author | : Lene Jorgensen |
| Publisher | : John Wiley & Sons |
| Total Pages | : 442 |
| Release | : 2009-10-23 |
| Genre | : Science |
| ISBN | : 0470688408 |
Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.
| Author | : Michael J. Rathbone |
| Publisher | : CRC Press |
| Total Pages | : 1021 |
| Release | : 2002-11-07 |
| Genre | : Medical |
| ISBN | : 0824708695 |
Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.
| Author | : Kishor M.Wasan |
| Publisher | : MDPI |
| Total Pages | : 352 |
| Release | : 2019-12-19 |
| Genre | : Science |
| ISBN | : 303928004X |
Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed from the inventions conceived and developed within academic institutions that have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases. This Special Issue serves to highlight and capture the contemporary progress of drug delivery within the prevailing Canadian context. We invite articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.
| Author | : Ambikanandan Misra |
| Publisher | : Springer Nature |
| Total Pages | : 448 |
| Release | : 2020-02-12 |
| Genre | : Medical |
| ISBN | : 9811336423 |
The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.
| Author | : Prashant L. Pingale |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 668 |
| Release | : 2024-09-02 |
| Genre | : Science |
| ISBN | : 3111320847 |
Nanotechnology can treat diseases by site-specific and target-oriented delivery of precise medicines. Nanomaterials improve the efficacy of drugs and selective diagnosis. The book covers detection and treatment. It explains the use of nanocarriers for a variety of diseases such as cardiovascular and respiratory diseases, cancer, and ulcerative colitis. It includes topical, transdermal, and ocular drug delivery and combined medication delivery.
| Author | : Keservani, Raj K. |
| Publisher | : IGI Global |
| Total Pages | : 530 |
| Release | : 2016-08-24 |
| Genre | : Medical |
| ISBN | : 1522507558 |
Technological innovations have become the impetus for continuous developments in medical research. With the assistance of new technologies, effective drug delivery techniques have been improved for optimal patient care. Recent Advances in Drug Delivery Technology is a pivotal reference source for the latest scholarly research on the application of pharmaceutical technology to optimize techniques for drug delivery in patients. Focusing on novel approaches in pharmaceutical science, this book is ideally designed for medical practitioners, upper-level students, scientists, and researchers.
| Author | : Emmanuel Opara |
| Publisher | : CRC Press |
| Total Pages | : 369 |
| Release | : 2020-02-28 |
| Genre | : Medical |
| ISBN | : 0429584652 |
This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
| Author | : Mr. Mahaveer Singh |
| Publisher | : Shashwat Publication |
| Total Pages | : 214 |
| Release | : 2024-05-03 |
| Genre | : Medical |
| ISBN | : 9360875694 |
Introducing the book "Novel Drug Delivery System" is something that fills me with an incredible amount of joy. The content of this book has been meticulously crafted to adhere to the curriculum for Bachelor of Pharmacy students that has been outlined by the Pharmacy Council of India. An effort has been made to investigate the topic using terminology that is as straightforward as possible in order to make it more simply digestible for pupils. The book has a number of illustrations, such as flowcharts and diagrams that make it simple for students to comprehend complex ideas. It is the author's honest desire that both students and academicians would take something helpful away from reading this book. The formulation development process is built upon the foundation of the pharmaceutical product development process. During the development of the product, the formulation scientist is responsible for paying attention to several parameters connected to the material (API, Excipients, and so on), the formulation process, the parameters of the formulation process, dosage forms, and so on. In this book, a variety of formulation development-related topics, including those pertaining to dosage, are broken down in a way that is clear and easy to grasp.
