Endosomes

Endosomes
Author: Ivan Dikic
Publisher: Springer Science & Business Media
Total Pages: 167
Release: 2008-05-07
Genre: Science
ISBN: 0387399518

Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics. Endosomes represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book.

The Golgi Apparatus

The Golgi Apparatus
Author: Alexander A. Mironov
Publisher: Springer Science & Business Media
Total Pages: 714
Release: 2009-03-04
Genre: Science
ISBN: 3211763104

This book summarizes all new data obtained after development of methods of Golgi complex sub fractionation, molecular biology and microscopy. It collects the full range of expertise, different points of view and different approaches. The book is devoted to molecular modes of the function of the Golgi apparatus as a whole, taking into account all experimental data. The book aims to make the functional organization of the Golgi apparatus more understandable.

Endosome Signaling Part A

Endosome Signaling Part A
Author:
Publisher: Academic Press
Total Pages: 411
Release: 2013-12-17
Genre: Science
ISBN: 0123984823

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes on endosome signaling and includes chapters on such topics as measurement of entry into the endosomal compartment by multi-parametric image analysis, assessment of peptide internalization and endosomal signaling, and VEGF-A in endosomal signaling. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers endosome signaling - Contains chapters on such topics as measurement of biological effects of endosomal proteolysis of internalized insulin and multi-vesicular endosome biogenesis.

The Biogenesis of Cellular Organelles

The Biogenesis of Cellular Organelles
Author: Chris Mullins
Publisher: Springer Science & Business Media
Total Pages: 196
Release: 2005
Genre: Mathematics
ISBN: 9780306479908

Theory of organelle biogenesis : a historical perspective / Barbara M. Mullock and J. Paul Luzio -- Protein coats as mediators of intracellular sorting and organelle biogenesis / Chris Mullins -- The role of proteins and lipids in organelle biogenesis in the secretory pathway / Thomas F.J. Martin -- Endoplasmic reticulum biogenesis : proliferation and differentiation / Erik Snapp -- The golgi apparatus : structure, function and cellular dynamics / Nihal Altan-Bonnet and Jennifer Lippincott-Schwartz -- Lysosome biogenesis and dynamics / Diane McVey Ward, Shelly L. Shiflett and Jerry Kaplan -- Nucleogenesis / Sui Huang -- Mitochondrial biogenesis / Danielle Leuenberger, Sean P. Curran and Carla M. Koehler -- The biogenesis and cell biology of peroxisomes in human health and disease / Stanley R. Terlecky and Paul A. Walton.

Sorting and Recycling Endosomes

Sorting and Recycling Endosomes
Author:
Publisher: Academic Press
Total Pages: 450
Release: 2015-09-14
Genre: Science
ISBN: 0128028718

Sorting and Recycling Endosomes provides the latest information on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos designated to lysosomes, Golgi, or plasma membrane. In recent years, the importance of endosomes as a sorting and recycling compartment has become increasingly appreciated. As such, scientists from various fields of cell biology, membrane traffic, and beyond, see the needs to communicate and learn about the methods used to investigate the dynamics and functions of endosomes. This book brings together specialists from the field who contribute their expertise on a broad range of biomedical topics that will provide ideal reading for researchers interested in endosomal sorting and recycling. This volume covers the approaches necessary to study the key components that mediate the generation and transport of membrane-bounded carriers from the endosomes, and how membrane trafficking machinery is coordinated with cytoskeletons during these processes. In addition to studies carried out in mammalian cells, other model systems such as worm and yeast are also included. - Provides the latest information on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos designated to lysosomes, Golgi, or plasma membrane. - Covers an increasingly appreciated field in cell biology - Includes both established and new technologies - Brings together specialists from the field who contribute their expertise on a broad range of biomedical topics that will provide ideal reading for researchers interested in endosomal sorting and recycling

EGFR Signaling Networks in Cancer Therapy

EGFR Signaling Networks in Cancer Therapy
Author: John D. Haley
Publisher: Springer Science & Business Media
Total Pages: 393
Release: 2009-03-01
Genre: Medical
ISBN: 1597453560

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

Trafficking Inside Cells

Trafficking Inside Cells
Author: Nava Segev
Publisher: Springer Science & Business Media
Total Pages: 459
Release: 2010-05-30
Genre: Science
ISBN: 038793877X

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Lewin's CELLS

Lewin's CELLS
Author: Lynne Cassimeris
Publisher: Jones & Bartlett Learning
Total Pages: 1079
Release: 2011-03-25
Genre: Science
ISBN: 076376664X

Completely revised and updated to incorporate the latest data in the field, Lewin's CELLS, Second Edition is the ideal resource for advanced undergraduate and graduate students entering the world of cell biology. Redesigned to incorporate new learning tools and elements, this edition continues to provide readers with current coverage of the structure, organization, growth, regulation, movements, and interaction of cells, with an emphasis on eukaryotic cells. Under the direction of three expert lead editors, new chapters on metabolism and general molecular biology have been added by subject specialist. All chapters have been carefully edited to maintain consistent use of terminology and to achieve a homogenous level of detail and rigor. A new design incorporates many new pedagogical elements, including Concept & Reasoning Questions, Methods boxes, Clinical Applications boxes, and more.