Empirical Bayes Methods
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Author | : Bradley Efron |
Publisher | : Cambridge University Press |
Total Pages | : |
Release | : 2012-11-29 |
Genre | : Mathematics |
ISBN | : 1139492136 |
We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.
Author | : Herbert Robbins |
Publisher | : |
Total Pages | : 24 |
Release | : 1955 |
Genre | : Bayesian statistical decision theory |
ISBN | : |
Author | : |
Publisher | : Elsevier |
Total Pages | : 545 |
Release | : 2016-04-20 |
Genre | : Mathematics |
ISBN | : 0444635718 |
Data Gathering, Analysis and Protection of Privacy through Randomized Response Techniques: Qualitative and Quantitative Human Traits tackles how to gather and analyze data relating to stigmatizing human traits. S.L. Warner invented RRT and published it in JASA, 1965. In the 50 years since, the subject has grown tremendously, with continued growth. This book comprehensively consolidates the literature to commemorate the inception of RR. - Brings together all relevant aspects of randomized response and indirect questioning - Tackles how to gather and analyze data relating to stigmatizing human traits - Gives an encyclopedic coverage of the topic - Covers recent developments and extrapolates to future trends
Author | : Bradley P. Carlin |
Publisher | : CRC Press |
Total Pages | : 552 |
Release | : 2008-06-30 |
Genre | : Mathematics |
ISBN | : 9781584886983 |
Broadening its scope to nonstatisticians, Bayesian Methods for Data Analysis, Third Edition provides an accessible introduction to the foundations and applications of Bayesian analysis. Along with a complete reorganization of the material, this edition concentrates more on hierarchical Bayesian modeling as implemented via Markov chain Monte Carlo (MCMC) methods and related data analytic techniques. New to the Third Edition New data examples, corresponding R and WinBUGS code, and homework problems Explicit descriptions and illustrations of hierarchical modeling—now commonplace in Bayesian data analysis A new chapter on Bayesian design that emphasizes Bayesian clinical trials A completely revised and expanded section on ranking and histogram estimation A new case study on infectious disease modeling and the 1918 flu epidemic A solutions manual for qualifying instructors that contains solutions, computer code, and associated output for every homework problem—available both electronically and in print Ideal for Anyone Performing Statistical Analyses Focusing on applications from biostatistics, epidemiology, and medicine, this text builds on the popularity of its predecessors by making it suitable for even more practitioners and students.
Author | : Giovanni Parmigiani |
Publisher | : Springer Science & Business Media |
Total Pages | : 511 |
Release | : 2006-04-11 |
Genre | : Medical |
ISBN | : 0387216790 |
This book presents practical approaches for the analysis of data from gene expression micro-arrays. It describes the conceptual and methodological underpinning for a statistical tool and its implementation in software. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.
Author | : S.E. Ahmed |
Publisher | : Springer Science & Business Media |
Total Pages | : 260 |
Release | : 2001 |
Genre | : Mathematics |
ISBN | : 9780387950181 |
Bayesian and such approaches to inference have a number of points of close contact, especially from an asymptotic point of view. Both emphasize the construction of interval estimates of unknown parameters. In this volume, researchers present recent work on several aspects of Bayesian, likelihood and empirical Bayes methods, presented at a workshop held in Montreal, Canada. The goal of the workshop was to explore the linkages among the methods, and to suggest new directions for research in the theory of inference.
Author | : Bradley P. Carlin |
Publisher | : Chapman and Hall/CRC |
Total Pages | : 440 |
Release | : 2000-06-22 |
Genre | : Mathematics |
ISBN | : 9781584881704 |
In recent years, Bayes and empirical Bayes (EB) methods have continued to increase in popularity and impact. Building on the first edition of their popular text, Carlin and Louis introduce these methods, demonstrate their usefulness in challenging applied settings, and show how they can be implemented using modern Markov chain Monte Carlo (MCMC) methods. Their presentation is accessible to those new to Bayes and empirical Bayes methods, while providing in-depth coverage valuable to seasoned practitioners. With its broad appeal as a text for those in biomedical science, education, social science, agriculture, and engineering, this second edition offers a relatively gentle and comprehensive introduction for students and practitioners already familiar with more traditional frequentist statistical methods. Focusing on practical tools for data analysis, the book shows how properly structured Bayes and EB procedures typically have good frequentist and Bayesian performance, both in theory and in practice.
Author | : David R. Bickel |
Publisher | : CRC Press |
Total Pages | : 141 |
Release | : 2019-09-24 |
Genre | : Mathematics |
ISBN | : 1000706915 |
Statisticians have met the need to test hundreds or thousands of genomics hypotheses simultaneously with novel empirical Bayes methods that combine advantages of traditional Bayesian and frequentist statistics. Techniques for estimating the local false discovery rate assign probabilities of differential gene expression, genetic association, etc. without requiring subjective prior distributions. This book brings these methods to scientists while keeping the mathematics at an elementary level. Readers will learn the fundamental concepts behind local false discovery rates, preparing them to analyze their own genomics data and to critically evaluate published genomics research. Key Features: * dice games and exercises, including one using interactive software, for teaching the concepts in the classroom * examples focusing on gene expression and on genetic association data and briefly covering metabolomics data and proteomics data * gradual introduction to the mathematical equations needed * how to choose between different methods of multiple hypothesis testing * how to convert the output of genomics hypothesis testing software to estimates of local false discovery rates * guidance through the minefield of current criticisms of p values * material on non-Bayesian prior p values and posterior p values not previously published
Author | : Shayle R. Searle |
Publisher | : John Wiley & Sons |
Total Pages | : 537 |
Release | : 2009-09-25 |
Genre | : Mathematics |
ISBN | : 0470317698 |
WILEY-INTERSCIENCE PAPERBACK SERIES The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. ". . .Variance Components is an excellent book. It is organized and well written, and provides many references to a variety of topics. I recommend it to anyone with interest in linear models." —Journal of the American Statistical Association "This book provides a broad coverage of methods for estimating variance components which appeal to students and research workers . . . The authors make an outstanding contribution to teaching and research in the field of variance component estimation." —Mathematical Reviews "The authors have done an excellent job in collecting materials on a broad range of topics. Readers will indeed gain from using this book . . . I must say that the authors have done a commendable job in their scholarly presentation." —Technometrics This book focuses on summarizing the variability of statistical data known as the analysis of variance table. Penned in a readable style, it provides an up-to-date treatment of research in the area. The book begins with the history of analysis of variance and continues with discussions of balanced data, analysis of variance for unbalanced data, predictions of random variables, hierarchical models and Bayesian estimation, binary and discrete data, and the dispersion mean model.
Author | : Leonhard Held |
Publisher | : Springer Science & Business Media |
Total Pages | : 381 |
Release | : 2013-11-12 |
Genre | : Mathematics |
ISBN | : 3642378870 |
This book covers modern statistical inference based on likelihood with applications in medicine, epidemiology and biology. Two introductory chapters discuss the importance of statistical models in applied quantitative research and the central role of the likelihood function. The rest of the book is divided into three parts. The first describes likelihood-based inference from a frequentist viewpoint. Properties of the maximum likelihood estimate, the score function, the likelihood ratio and the Wald statistic are discussed in detail. In the second part, likelihood is combined with prior information to perform Bayesian inference. Topics include Bayesian updating, conjugate and reference priors, Bayesian point and interval estimates, Bayesian asymptotics and empirical Bayes methods. Modern numerical techniques for Bayesian inference are described in a separate chapter. Finally two more advanced topics, model choice and prediction, are discussed both from a frequentist and a Bayesian perspective. A comprehensive appendix covers the necessary prerequisites in probability theory, matrix algebra, mathematical calculus, and numerical analysis.