The effects of lift-roll coupling on the handling qualities of hovering VTOL aircraft using differential thrust for roll control were assessed in a piloted simulation study in the Ames six-degrees-of-freedom motion simulator. The configuration tested has three vertical thrust sources, one on the roll axis and two laterally displaced from the roll axis, with a thrust distribution of 25/50/25. The outboard thrust sources were modulated to provide roll control whereas all three provided height control. Maximum thrust-to-weight ratio was varied together with a coupling parameter that combined roll-inertia, weight, and engine location. Results showed that handling qualities are affected not only by the occurrence of lift-roll coupling (dependent on both variables) but also by the severity of the coupling (dependent on the coupling parameter alone). However, the advantages of differential thrust for control can be retained with careful design.