Integrative Structural Biology of Proteins and Macromolecular Assemblies: Bridging Experiments and Simulations
| Author | : Paulo Ricardo Batista |
| Publisher | : Frontiers Media SA |
| Total Pages | : 148 |
| Release | : 2022-07-26 |
| Genre | : Science |
| ISBN | : 2889766101 |
Dynamics Of Proteins And Macromolecular Assemblies
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Macromolecular Crystallography
| Author | : Maria Armenia Carrondo |
| Publisher | : Springer |
| Total Pages | : 213 |
| Release | : 2011-12-01 |
| Genre | : Science |
| ISBN | : 9400725302 |
This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.
Macromolecular Protein Complexes II: Structure and Function
| Author | : J. Robin Harris |
| Publisher | : Springer Nature |
| Total Pages | : 657 |
| Release | : 2020-01-14 |
| Genre | : Science |
| ISBN | : 3030281515 |
This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Conformational Proteomics Of Macromolecular Architecture: Approaching The Structure Of Large Molecular Assemblies And Their Mechanisms Of Action (With Cd-rom)
| Author | : R Holland Cheng |
| Publisher | : World Scientific |
| Total Pages | : 433 |
| Release | : 2004-06-21 |
| Genre | : Science |
| ISBN | : 9814483966 |
Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this important book presents cutting-edge knowledge in the various fields of structural proteomics of very large molecular assemblies, with the focus on their mechanisms of action.
Multiscale Approaches to Protein Modeling
| Author | : Andrzej Kolinski |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 360 |
| Release | : 2010-10-13 |
| Genre | : Science |
| ISBN | : 144196889X |
The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. This book is intended to be used as a reference book for those who are just beginning their adventure with biomacromolecular modeling but also as a valuable source of detailed information for those who are already experts in the field of biomacromolecular modeling and in related areas of computational biology or biophysics.
Protein Complex Assembly
| Author | : Joseph A. Marsh |
| Publisher | : Humana |
| Total Pages | : 506 |
| Release | : 2019-04-15 |
| Genre | : Science |
| ISBN | : 9781493992775 |
This volume details the importance of multiple experimental techniques and computational methods needed to obtain the comprehensive picture of protein complex structure, dynamics and assembly afforded by the emerging field of integrative structural biology. Chapters guide readers through the broad spectrum of approaches required for a complete representation of protein complexes, including expression and purification, experimental characterization of structure and assembly, and computational methods for identifying protein complexes and modelling their assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein Complex Assembly: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Protein Self-Assembly
| Author | : Jennifer J. McManus |
| Publisher | : Humana |
| Total Pages | : 266 |
| Release | : 2020-08-08 |
| Genre | : Science |
| ISBN | : 9781493996803 |
This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.
Dynamics, Structure, and Function of Biological Macromolecules
| Author | : Oleg Jardetzky |
| Publisher | : IOS Press |
| Total Pages | : 212 |
| Release | : 2001 |
| Genre | : Biomolecules |
| ISBN | : 9781586030322 |
A collection of articles looking at modern structural biology, summarizing the applications of physical methods - such as x-ray diffraction, high resolution nuclear magnetic resonance and molecular dynamics - to the study of protein structure and dynamics. There is a review of contemporary thoughts within the field, looking at the mechanisms of alloateric transitions and allosteric control, the transmission of information within protein structures and the role of dynamics in determining the specificity of protein - ligand interactions. There is also a look at future innovations.
Macromolecular Protein Complexes III: Structure and Function
| Author | : J. Robin Harris |
| Publisher | : Springer Nature |
| Total Pages | : 580 |
| Release | : 2020-11-30 |
| Genre | : Science |
| ISBN | : 3030589714 |
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
