Dynamic Skin On A Chip Models
Download Dynamic Skin On A Chip Models full books in PDF, epub, and Kindle. Read online free Dynamic Skin On A Chip Models ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : Aditya Bhushan Pant |
| Publisher | : Springer Nature |
| Total Pages | : 266 |
| Release | : 2023-08-28 |
| Genre | : Medical |
| ISBN | : 9819928044 |
Efforts are being made by research organizations and cosmetic industries worldwide to develop more precise and targeted 3D models that mimic humans for testing cosmetic and personal health care product ingredients, following a complete ban on animal testing. This book includes several subtopics dedicated to the progress made, challenges faced, roadblocks encountered, and future prospects in the development and validation of 3D models for testing these products. The book consist of an editorial and 14 themed chapters that will showcase the significant progress made so far, challenges encountered, and future prospects in the development of 3D reconstruct models.
| Author | : Masoud Mozafari |
| Publisher | : Woodhead Publishing |
| Total Pages | : 492 |
| Release | : 2023-01-17 |
| Genre | : Technology & Engineering |
| ISBN | : 0128236108 |
Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. - Describes various microfluidic systems and fabrication methods - Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more - Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips
| Author | : Alexandra P. Marques |
| Publisher | : Academic Press |
| Total Pages | : 474 |
| Release | : 2017-11-14 |
| Genre | : Science |
| ISBN | : 0128110007 |
Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury – from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies. The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models. - Offers descriptions of the normal structure/function of mammalian skin, exposure to clinical problems, and more - Presents coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) that extends to clinical requirements and skin diseases in vitro models - Addresses legal requirements and ethical concerns in drugs and cosmetics in vitro testing - Edited and authored by internationally renowned group of researchers, presenting the broadest coverage possible
| Author | : P. V. Mohanan |
| Publisher | : Springer Nature |
| Total Pages | : 712 |
| Release | : 2022-07-11 |
| Genre | : Medical |
| ISBN | : 981191379X |
This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
| Author | : Madhulika Pradhan |
| Publisher | : CRC Press |
| Total Pages | : 439 |
| Release | : 2024-09-18 |
| Genre | : Medical |
| ISBN | : 1040131875 |
3D Printing and Microfluidics in Dermatology provides a thorough exploration and applications of three-dimensional (3D) printing and microfluidics within the field of dermatology. It investigates various methods utilized in these fields, such as 3D bioprinting, nano-transporters, microscopic fabrication, and device development. The book not only examines practical applications but also delves into the design principles crucial for implementing these techniques using specific materials tailored to their intended purposes. Additionally, it addresses ethical concerns and regulatory considerations pertinent to these evolving technologies. Key highlights include the following: A detailed insight into the utilization of 3D printing and microfluidic technologies for treating skin disorders. Exploration of design concepts necessary for effective implementation, considering the unique properties of materials involved. Coverage of diverse methodologies, ranging from 3D bioprinting to nano-transporters, microscopic fabrication, and device engineering. In-depth discussion on ethical considerations vital for the sustainable development of the industry. Investigation into advancements in material development, device design, fabrication techniques, and performance evaluation through preclinical and clinical studies. This book targets graduate students and researchers in fields such as 3D printing, dermatology, drug delivery, bioengineering, and pharmaceutical sciences.
| Author | : Tanja Zidarič |
| Publisher | : Springer Nature |
| Total Pages | : 170 |
| Release | : 2023-01-01 |
| Genre | : Technology & Engineering |
| ISBN | : 3031212983 |
The book Function-oriented bioengineered skin equivalents - continuous development towards complete skin replication aims to provide potential readers with a comprehensive summary of the available information on various in vitro skin models, from historical background to different modeling approaches and their applications. Particular emphasis is placed on presenting the current technological components available for the development of engineered skin equivalents by summarizing advances in cell cultivation, materials science, and bioengineering. Using examples of the current-state-of-art, we describe the advantages, limitations, and challenges of developing in vitro skin models for successful use in clinical applications and skin-related research.
| Author | : Fabio Bagnoli |
| Publisher | : Springer Nature |
| Total Pages | : 265 |
| Release | : 2021-05-20 |
| Genre | : Medical |
| ISBN | : 3030624528 |
This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab. Chapters 'Progress on Reconstructed Human Skin Models for Allergy Research and Identifying Contact Sensitizers' and 'Human Organotypic Models for Anti-infective Research' of this book are available open access under a CC BY 4.0 license at link.springer.com.
| Author | : Subhas C. Kundu |
| Publisher | : Elsevier |
| Total Pages | : 773 |
| Release | : 2020-08-22 |
| Genre | : Technology & Engineering |
| ISBN | : 012818129X |
Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. - Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles - Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types - Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery
| Author | : Bruno Sarmento |
| Publisher | : Elsevier |
| Total Pages | : 708 |
| Release | : 2024-02-23 |
| Genre | : Medical |
| ISBN | : 0443155119 |
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route. Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules. - Summarizes the current advances in the use of permeability models in drug transport - Covers the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, renal, skin, and blood–brain barrier in vitro models. Includes case studies to facilitate understanding of various concepts in computer-aided applications - Updates in the second edition include organ-on-chip devices, 3D advanced models (multiple layered tissues, organoids, etc.), and multicompartmentalized tissue models
| Author | : Javier Ramón-Azcón |
| Publisher | : Elsevier |
| Total Pages | : 380 |
| Release | : 2023-11-15 |
| Genre | : Science |
| ISBN | : 044315385X |
Human Organs-on-Chip: Novel Organ-on-a-Chip Techniques in Medicine paves the way for novel approaches that push forward in-vitro and in-vivo studies and fills a gap between laboratory and clinical use. These experienced authors share the knowledge they've developed with over a decade of experience and research with organ-on-chips and multi-organ-on-chips. This book collects all of the developments in the field and sheds new light on possibilities to develop human on-chip measurement methods with the utilization of currently available measurement techniques including both invasive and non-invasive tests. Human Organs-on-Chip: Novel Organ-on-a-Chip Techniques in Medicine serves as a starting point for young researchers who are beginning their scientific journeys. - Provides an overview of the progress suborgan-on-chips development has made in recent years - Introduces the fundamentals needed to understand lab-on-chip ideas with references and in-depth explanations - Presents commercial achievements obtained and future perspectives
