Drug-Resistance in Cancer Cells: A New Wine in an old Bottle
Author | : Leonardo Freire-de-Lima |
Publisher | : Frontiers Media SA |
Total Pages | : 226 |
Release | : 2023-04-05 |
Genre | : Medical |
ISBN | : 2832518486 |
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Author | : Leonardo Freire-de-Lima |
Publisher | : Frontiers Media SA |
Total Pages | : 226 |
Release | : 2023-04-05 |
Genre | : Medical |
ISBN | : 2832518486 |
Author | : Yusuf A. Hannun |
Publisher | : Springer |
Total Pages | : 491 |
Release | : 2015-08-28 |
Genre | : Medical |
ISBN | : 3319207504 |
This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.
Author | : Robert A. Parsons |
Publisher | : Nova Publishers |
Total Pages | : 240 |
Release | : 2007 |
Genre | : Medical |
ISBN | : 9781600218224 |
One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100 percent effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common.The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information on how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs.
Author | : Robert O. Williams |
Publisher | : CRC Press |
Total Pages | : 532 |
Release | : 2007-09-25 |
Genre | : Medical |
ISBN | : 1420043889 |
This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targ
Author | : Kamal Dua |
Publisher | : Academic Press |
Total Pages | : 620 |
Release | : 2020-08-04 |
Genre | : Technology & Engineering |
ISBN | : 0128208880 |
Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. - Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases - Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases - Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)
Author | : |
Publisher | : |
Total Pages | : 2388 |
Release | : 2004 |
Genre | : Medicine |
ISBN | : |
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author | : Bhupinder Singh |
Publisher | : CRC Press |
Total Pages | : 433 |
Release | : 2018-11-19 |
Genre | : Science |
ISBN | : 1351139266 |
This book volume encompasses the recent trends made in the applications of nanoscale tools for diverse constituents of plants and agriculture, particularly in addressing the critical issues related to their safety, efficacy, and efficient and cost-efficient development and production.
Author | : Sahdeo Prasad |
Publisher | : Bentham Science Publishers |
Total Pages | : 213 |
Release | : 2017-05-11 |
Genre | : Medical |
ISBN | : 1681084910 |
Cancer is a major cause of deaths all around the globe. Although numerous anticancer drugs are available, most of them are expensive and have serious side effects. Natural compounds are usually non-toxic and inexpensive. Many such compounds have been identified and explored for their health benefits for centuries, and several nutritional factors derived from natural products have attracted considerable attention as therapeutic agents for the prevention and treatment of cancer. Based on current available research, this ebook focuses on chemopreventive and anti-cancer activities of different natural/dietary compounds present in fruits, vegetable, spices, legumes, nuts, grains, and cereals. Contributions from authors around the world highlight the potential use of such derivatives against cancer treatment by presenting updated information of their biochemical mechanisms. Information in this book is intended for researchers, clinicians, patients, academicians, industrialists, and students seeking updated and critical information for their experimental plans (including clinical trials). The book also creates awareness among cancer patients, nutritionists and laymen about cost effective therapeutic alternatives available for cancer therapy.
Author | : Siddhartha Mukherjee |
Publisher | : Simon and Schuster |
Total Pages | : 624 |
Release | : 2011-08-09 |
Genre | : Health & Fitness |
ISBN | : 1439170916 |
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Author | : Caterina Garone |
Publisher | : Frontiers Media SA |
Total Pages | : 167 |
Release | : 2020-12-15 |
Genre | : Science |
ISBN | : 2889662322 |
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