As universities transform cities with their innovation districts, what works in these new public-private partnerships? In recent years, the successful revitalization of urban areas has turned them into magnets for those looking for opportunities in a fast-paced and rapidly unfolding technology-based economy. After the economic crisis of 2008, many colleges and universities attempted to generate alternative sources of revenue and pursued aggressive economic development strategies. Some universities even began to actively invest resources in the rebirth (and rebranding) of urban cores, encouraging the development of entrepreneurial, technology-oriented innovation districts. In Anchoring Innovation Districts, Costas Spirou explains that these districts have emerged as geographic clusters of technology startups, business incubators, and accelerators. They aim to take advantage of intellectual capital, commercialize knowledge, and give their associated institutions a way to enter into the market. The outcome of robust private-public partnerships and complex real estate strategies, these initiatives also complement other urban revitalization efforts and reshape the socioeconomic makeup of city neighborhoods. Presenting readers with six case studies that explore the role of technological innovation, Spirou argues that higher education–anchored innovation districts can make significant contributions to economic expansion, job growth, and the institutions that guide their development. He also points out that these districts nonetheless raise questions about the impact of the Ivory Tower on the urban environment. Spirou focuses on Midtown Atlanta's Tech Square (Georgia Tech), Cambridge's Kendall Square (MIT), Philadelphia's University City (the University of Pennsylvania, Drexel University, and the University of the Sciences), the PHX Core (Arizona State University), and the role that the University of West Florida in Pensacola and the University of Tennessee at Chattanooga play in developing innovation ecosystems. Anchoring Innovation Districts provides unique insight into the transformative opportunities offered and the challenges faced by higher education in the built environment. University administrators, board members, policy makers, and scholars will find Spirou's analysis thought-provoking and helpful.