Down Syndrome Across the Life Span

Down Syndrome Across the Life Span
Author: Monica Cuskelly
Publisher: John Wiley & Sons
Total Pages: 300
Release: 2008-04-30
Genre: Psychology
ISBN: 0470777982

This book promotes a positive message for people with Down syndrome across the world. Living with Down Syndrome is a positive experience for the majority of children and adults with Down syndrome, and for their families. Of course there are difficulties to be faced, but quality of life, from infancy to old age, is determined more by the quality of healthcare, education and social inclusion offered to individuals, than by the developmental difficulties that are associated with Down syndrome. The aim of this book is to bring the latest information on research and good practice to families, practitioners and policy makers in order improve the services available to individuals with Down syndrome in all countries.

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome
Author: Elizabeth Head
Publisher: Academic Press
Total Pages: 354
Release: 2021-08-31
Genre: Medical
ISBN: 0128188464

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Living with Down Syndrome

Living with Down Syndrome
Author: Sue Buckley
Publisher: DSE Enterprises
Total Pages: 34
Release: 2000
Genre: Down syndrome
ISBN: 1903806011

Offers a person-focused introduction to Down syndrome. This book explains the effects of Down syndrome on development, stressing that while individuals with Down syndrome do have special needs, they are people first, with the same rights and human needs as everyone else in their communities.

Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment

Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment
Author: Marie-Claude Potier
Publisher: Frontiers Media SA
Total Pages: 183
Release: 2017-02-24
Genre:
ISBN: 2889450457

Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Down Syndrome

Down Syndrome
Author: Margaret B Pulsifer
Publisher: Mdpi AG
Total Pages: 180
Release: 2022-05-09
Genre: Science
ISBN: 9783036539621

Down syndrome (DS), caused by the triplication of chromosome 21, is the most common genetic cause of intellectual disability (ID). Individuals with DS commonly exhibit unique neuropsychological profiles that emerge during specific developmental stages across the lifespan, often characterized by early developmental delay, cognitive strengths and weaknesses, behavior and mental health issues, and age-related cognitive decline, frequently resulting in early-onset Alzheimer's disease. These profiles are unique compared to other individuals with ID and reflect the genetic mechanisms and neuroanatomic features underlying the distinct neuropsychological phenotype associated with DS. This Special Issue aims to highlight the recent advancements in understanding the neuropsychological phenotype associated with DS across the lifespan. The lifespan perspective will cover four developmental stages: (1) early childhood; (2) school age; (3) young adulthood, and (4) older adulthood. Authors contributed cutting-edge original research studies and comprehensive reviews that address a broad range of topics related to DS, including early developmental trajectories, cognitive functioning, language, adaptive skills, behavior and mental health, assessment and diagnosis, age-related cognitive decline, and medical issues related to the neuropsychological phenotype and neuroimaging.

Down Syndrome

Down Syndrome
Author: Lynn Nadel
Publisher: Wiley-Liss
Total Pages: 320
Release: 1995-02-20
Genre: Medical
ISBN:

Recent advances in medicine are allowing people with Down syndrome to live longer and more productively - while at the same time creating new medical and social challenges for them and the people who provide their care. Down Syndrome: Living and Learning in the Community, which was written under the auspices of the National Down Syndrome Society, provides long-awaited, state-of-the-art information and advice about the disease. This book will prove an invaluable tool for parents and health care professionals, enabling people with Down syndrome to cope with the problems they face and participate to the fullest in community life.

Neurodevelopmental Disorders Across the Lifespan

Neurodevelopmental Disorders Across the Lifespan
Author: Emily K. Farran
Publisher: OUP Oxford
Total Pages: 416
Release: 2011-12-15
Genre: Psychology
ISBN: 0191625620

Nowadays, it is widely accepted that there is no single influence (be it nature or nurture) on cognitive development. Cognitive abilities emerge as a result of interactions between gene expression, cortical and subcortical brain networks, and environmental influences. In recent years, our study of neurodevelopmental disorders has provided much valuable information on how genes, brain development, behaviour, and environment interact to influence development from infancy to adulthood. This is the first book to present evidence on development across the lifespan across these multiple levels of description (genetic, brain, cognitive, environmental). In the book, the authors have chosen a well-defined disorder, Williams syndrome (WS), to explore the impact of genes, brain development, behaviour, as well as the individual's environment on development. WS is used as a model disorder to demonstrate the authors approach to understanding development, whilst being presented in comparison to other neurodevelopmental disorders - Autism, Developmental Dyscalculia, Down syndrome, Dyslexia, Fragile X syndrome, Prader-Willi syndrome, Specific Language Impairment, Turner syndrome - to illustrate differences in development across neurodevelopmental disorders. Williams syndrome is particularly informative for exploring development: Firstly, it has been extensively researched at multiple levels: genes, brain, cognition and behaviour, as well as in terms of the difficulties of daily living and social interaction. Secondly, it has been studied across the lifespan, with many studies on infants and toddlers with WS as well as a large number on children, adolescents and adults. The authors also explore a number of domain-general and domain-specific processes in the verbal, non-verbal and social domains, across numerous neurodevelopmental disorders. This illustrates, among other factors, the importance of developmental timing, i.e. that the development of a cognitive skill at a specific timepoint can impact on subsequent development within that domain, but also across domains. In addition, the authors discuss the value of investigating basic-level abilities from as close to the infant start-state as possible, presenting evidence of where cross-syndrome comparisons have shed light on the cascading impacts of subtle similarities and discrepancies in early delay or deviance, on subsequent development. Designed such that readers with an interest in any neurodevelopmental disorder can gain insight into the intricate dynamics of cognitive development, the book covers both theoretical issues and those of clinical relevance. It will be an invaluable reference for any researcher, clinician, student as well as interested parents or teachers wishing to learn about neurodevelopmental disorders from a developmental framework.

International Review of Research in Mental Retardation

International Review of Research in Mental Retardation
Author: Richard C. Urbano
Publisher: Academic Press
Total Pages: 381
Release: 2010-10-14
Genre: Medical
ISBN: 0080922686

International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of mental retardation. This thematic volume, "Health Issues in Down Syndrome," will cover health issues for individuals across the life span. With the life expectancy of individuals now reaching 60 years or more, it has transformed from an acute condition with a short life span to a chronic condition that needs to be managed over a close to normal life span. The extra chromosome 21 that defines most cases of Down syndrome affects the functioning of many biological processes and organ systems. The cascade of events triggered by the extra chromosome 21 creates a complex set of medical conditions needing to managed over the life span. The ability to manage these conditions has led to an improvement in longevity and quality of life for individuals with Down syndrome. Provides the most recent scholarly research in the study of health issues in Down syndrome A vast range of perspectives is offered, and many topics are covered An excellent resource for academic researchers

Multimodal Aac for Individuals with Down Syndrome

Multimodal Aac for Individuals with Down Syndrome
Author: Krista M. Wilkinson
Publisher:
Total Pages: 296
Release: 2020-11-02
Genre:
ISBN: 9781681254128

This volume examines the role of multimodal augmentative and alternative communication (AAC) in supporting speech, language, and communication of individuals with Down syndrome, across the lifespan.