The explosive demand for high data rates and the need ubiquitous wireless connectivity has led to the phenomenon of network densification, the deployment of large number of base station within a geographic area. Since the radio spectrum is limited, wireless transmissions need to share a common resource which results in interference. Interference in turn creates a bottleneck on the communication rate. Recently three breakthroughs have been made to increase the capacity of wireless networks while mitigating interference : multiple input multiple output (MIMO) beamforming, interference alignment (IA) and pattern reconfigurable antennas (PRA). While a great deal of progress has been made on understanding each individually, relatively little is known about how to use these techniques in combination to increase system performance. In this dissertation, we analyze and experimentally evaluate how these new technologies can be leveraged to enhance the rate performance of communication networks. Specifically, we address three problems: i) enhancing multi-user MIMO performance with PRA, ii) improving IA performance with PRA-based antenna selection, and iii) enabling practical blind IA with PRA. To understand the impact PRAs on MU-MIMO and IA, it is necessary to evaluate their performance through measurements. Simulation-based studies often reiterate over set of simplistic channel models and unrealistic assumptions. This dissertation focuses on a measurement-based evaluation approach. For each of these problems, a hardware testbed implementation and measurement methodology is developed for evaluating the performance of the aforementioned technologies through efficient and repeatable experiments. The first two major contributions of this dissertation focus on multi-user MIMO (MU-MIMO) and IA. While the theoretical rate gains of MU-MIMO and IA are substantial, the performance gains in practical systems and measured channels have been limited. One of the key limiting factors are spatially correlated user channels. In this work, we propose MU-MIMO and IA transmission schemes that leverage the pattern diversity provided by PRAs to mitigate the effects of spatial correlation in wireless channels. PRAs are capable of dynamically adjusting their radiation pattern, providing an additional degree of freedom that can be exploited to improve MU-MIMO and IA performance by treating the array configuration and radiation characteristics as additional components in the joint optimization of adaptive system parameters. We quantify the benefits of pattern diversity on the rate performance of MU-MIMO and IA systems through extensive measurements. Furthermore, we develop efficient antenna mode selection algorithms to realize those benefits without increasing the system complexity or overhead, making these techniques suitable for practical implementation. The third contribution of this dissertation focuses on a transmission technique known as blind IA. In contrast to MU-MIMO and conventional IA, blind IA is signaling scheme that suppresses interference in multi-user systems, without the knowledge of channel state information at the transmitter (CSIT). The key to performing IA without CSIT is the use of PRAs that are capable of dynamically switching among a fixed number of radiation patterns to introduce artificial fluctuations in the channel. In this dissertation, we develop a novel implementation of a blind IA system on a software defined radio platform where each of the receivers is equipped with a PRA. Our work provides the first experimental evaluation of PRA-based blind IA schemes and demonstrates significant gains in rate and reliability over traditional orthogonal transmission schemes such as TDMA.