Dissecting The Mechanism Of Arp2 3 Complex Activation By Actin Filament Binding And The Regulation And Function Of Jmy In Cells
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Author | : Marie-France Carlier |
Publisher | : Springer Science & Business Media |
Total Pages | : 434 |
Release | : 2010-09-23 |
Genre | : Medical |
ISBN | : 904819301X |
Since the discovery of actin by Straub in the 1950’s and the pioneering work of Oosawa on actin self-assembly in helical laments in the 1960’s, many books and conference proceedings have been published. As one of the most essential p- teins in life, essential for movement in organisms rangingfrom bacteria to higher eukaryotes, it is no surprise that actin has fascinated generations of scientists from many different elds. Actin can be considered as a “living treasure” of biology; the kinetics and thermodynamics of self-assembly, the dissipative nature of actin po- merization, the molecular interactions of monomeric and polymerized actin with regulators, the mechanical properties of actin gels, and more recently the force p- ducing motile and morphogenetic processes organized by the actin nanomachine in response to signaling, are all milestones in actin research. Discoveries that directly derive from and provide deeper insight into the fundamental properties of actin are constantly being made, making actin an ever appealing research molecule. At the same time, the explosion in new technologies and techniques in biological sciences has served to attract researchers from an expanding number of disciplines, to study actin. This book presents the latest developments of these new multiscale approaches of force and movement powered by self-assembly processes, with the hope to opening our perspectives on the many areas of actin-based motility research.
Author | : Frances A. Jurnak |
Publisher | : Wiley-Interscience |
Total Pages | : 580 |
Release | : 1987 |
Genre | : Science |
ISBN | : |
Author | : Jürgen Bereiter-Hahn |
Publisher | : Springer Science & Business Media |
Total Pages | : 304 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 3642728634 |
Genetic information determines the composition of molecules comprising cytoskeletal elements, membranes and receptors. The supramolecular arrangement of these components represents a self-assembly process controlled by physicochemical and mechanical interactions. This general hypothesis demarcates the aim of studying cellular mechanics. Description and evaluation of mechanical properties of cells and their organelles, as well as of the forces exerted by them, is the scope of this book on Cytomechanics. Emphasis is laid on the role of mechanical properties in the generation of shape and cytoplasmic motion, and on the basic principles and components determining mechanical properties.
Author | : Gabriel J. Lord |
Publisher | : Cambridge University Press |
Total Pages | : 516 |
Release | : 2014-08-11 |
Genre | : Business & Economics |
ISBN | : 0521899907 |
This book offers a practical presentation of stochastic partial differential equations arising in physical applications and their numerical approximation.
Author | : Jozef Šamaj |
Publisher | : Springer Science & Business Media |
Total Pages | : 337 |
Release | : 2012-10-02 |
Genre | : Science |
ISBN | : 3642324622 |
Endocytosis is a fundamental cellular process by means of which cells internalize extracellular and plasma membrane cargos for recycling or degradation. It is important for the establishment and maintenance of cell polarity, subcellular signaling and uptake of nutrients into specialized cells, but also for plant cell interactions with pathogenic and symbiotic microbes. Endocytosis starts by vesicle formation at the plasma membrane and progresses through early and late endosomal compartments. In these endosomes cargo is sorted and it is either recycled back to the plasma membrane, or degraded in the lytic vacuole. This book presents an overview of our current knowledge of endocytosis in plants with a main focus on the key molecules undergoing and regulating endocytosis. It also provides up to date methodological approaches as well as principles of protein, structural lipid, sugar and microbe internalization in plant cells. The individual chapters describe clathrin-mediated and fluid-phase endocytosis, as well as flotillin-mediated endocytosis and internalization of microbes. The book was written for a broad spectrum of readers including students, teachers and researchers.
Author | : Hirokawa |
Publisher | : CRC Press |
Total Pages | : 360 |
Release | : 1994-01-12 |
Genre | : Science |
ISBN | : 9780849377419 |
This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.
Author | : Engelbert Buxbaum |
Publisher | : Springer |
Total Pages | : 521 |
Release | : 2015-11-27 |
Genre | : Science |
ISBN | : 331919920X |
This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
Author | : Alexander Birbrair |
Publisher | : Springer Nature |
Total Pages | : 155 |
Release | : 2020-02-06 |
Genre | : Science |
ISBN | : 3030362140 |
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Author | : Nava Segev |
Publisher | : Springer Science & Business Media |
Total Pages | : 459 |
Release | : 2010-05-30 |
Genre | : Science |
ISBN | : 038793877X |
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Author | : Brigitte M. Jockusch |
Publisher | : Springer |
Total Pages | : 356 |
Release | : 2017-01-03 |
Genre | : Medical |
ISBN | : 3319463713 |
Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.