Disordered Vertebral And Rib Morphology In Pudgy Mice
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Author | : Frederic Shapiro |
Publisher | : Springer |
Total Pages | : 131 |
Release | : 2016-09-21 |
Genre | : Medical |
ISBN | : 331943151X |
This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
Author | : Tony Waldron |
Publisher | : Cambridge University Press |
Total Pages | : 542 |
Release | : 2008-10-20 |
Genre | : Social Science |
ISBN | : 1139474006 |
Palaeopathology is designed to help bone specialists with diagnosis of diseases in skeletal assemblages. It suggests an innovative method of arriving at a diagnosis in the skeleton by applying what are referred to as 'operational definitions'. The aim is to ensure that all those who study bones will use the same criteria for diagnosing disease, which will enable valid comparisons to be made between studies. This book is based on modern clinical knowledge and provides background information so that those who read it will understand the natural history of bone diseases, and this will enable them to draw reliable conclusions from their observations. Details of bone metabolism and the fundamentals of basic pathology are also provided, as well as a comprehensive and up-to-date bibliography. A short chapter on epidemiology provides information on how best to analyze and present the results of a study of human remains.
Author | : Osama Naga |
Publisher | : Springer |
Total Pages | : 611 |
Release | : 2015-03-27 |
Genre | : Medical |
ISBN | : 3319101153 |
Covers the most frequently asked and tested points on the pediatric board exam. Each chapter offers a quick review of specific diseases and conditions clinicians need to know during the patient encounter. Easy-to-use and comprehensive, clinicians will find this guide to be the ideal final resource needed before taking the pediatric board exam.
Author | : Ruggero Caputo |
Publisher | : CRC Press |
Total Pages | : 448 |
Release | : 2005-12-12 |
Genre | : Medical |
ISBN | : 1841842516 |
A lavishly illustrated guide to almost 200 inherited diseases of the skin, hair, and nails. Each entry includes synonyms, age of onset, clinical findings, complications, course, laboratory findings, diagnosis, therapy, and key references, adding up to far more than just a collection of photographs. In addition to being a clinical primer, this is also a work of scientific research and contains the first printed description of two new syndromes. The fast-moving world of genetic research means that the latest genetic correlations, included here, render previous texts out of date. All specialists in Dermatology and Pediatrics should find this an invaluable front-line resource in the clinic.
Author | : Ruth Bellairs |
Publisher | : Springer Science & Business Media |
Total Pages | : 318 |
Release | : 2013-11-11 |
Genre | : Science |
ISBN | : 1489920137 |
Somite development is a unique and important topic; unique because somitic mesoderm is the first tissue to become segmented, important because the somites - once established - exert a profound influence on other seg mental structures which form later. Somite development is of interest at a number of levels. In one aspect, demarcation of a specific number of somites and size regulation, it is a particularly intriguing example of embryonic pattern formation, 'especially in vew of its possible relation to homoeobox-controlled segmentation in insects. At another level, somite development has long been studied by compara tive anatomists, but only recently has new light been thrown on such sub jects as segmentation of the head, proposed in the 18th century by Goethe and now a live issue for developmental biologists. Somit es are simple when they first appear, but very complex structures arise from them. These include the vertebrae and the axial and other muscles and consequently there is a wealth of morphogenetic problems to be explored. Sometimes their morphogenesis is disturbed, by genetic or environ mental factors, and there are many clinical conditions which arise as a result.
Author | : Alecsandru Ioan Baba |
Publisher | : |
Total Pages | : 787 |
Release | : 2007 |
Genre | : Electronic books |
ISBN | : 9789732714577 |
Author | : Enid Gilbert-Barness |
Publisher | : Cambridge University Press |
Total Pages | : 706 |
Release | : 2004-05-31 |
Genre | : Medical |
ISBN | : 9781139451741 |
Exhaustively illustrated in color with over 1000 photographs, figures, histopathology slides, and sonographs, this uniquely authoritative atlas provides the clinician with a visual guide to diagnosing congenital anomalies, both common and rare, in every organ system in the human fetus. It covers the full range of embryo and fetal pathology, from point of death, autopsy and ultrasound, through specific syndromes, intrauterine problems, organ and system defects to multiple births and conjoined twins. Gross pathologic findings are correlated with sonographic features in order that the reader may confirm visually the diagnosis of congenital abnormalities for all organ systems. Obstetricians, perinatologists, neonatologists, geneticists, anatomic pathologists, and all practitioners of maternal-fetal medicine will find this atlas an invaluable resource.
Author | : Juan M. Pascual |
Publisher | : Cambridge University Press |
Total Pages | : 507 |
Release | : 2017-04-20 |
Genre | : Medical |
ISBN | : 1107042054 |
A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.
Author | : Donald B. Brinkman |
Publisher | : Springer Science & Business Media |
Total Pages | : 577 |
Release | : 2012-08-16 |
Genre | : Science |
ISBN | : 9400743084 |
This volume celebrates the contributions of Dr. Eugene Gaffney to the study of turtles, through a diverse and complementary collection of papers that showcases the latest research on one of the most intriguing groups of reptiles. A mix of focused and review papers deals with numerous aspects of the evolutionary history of turtles, including embryonic development, origins, early diversification, phylogenetic relationships, and biogeography. Moreover it includes reports on important but poorly understood fossil turtle assemblages, provides historical perspectives on turtle research, and documents disease and variation in turtles. With its broad scope, which includes descriptions of material and new taxa from Australia, Asia, and Europe, as well as North and South America, this work will be an essential resource for anyone interested in the morphology and evolution of turtles. “This volume’s breadth of time, geography, and taxonomic coverage makes it a major contribution to the field and a ‘must have’ for all vertebrate paleontologists.”, James F. Parham, California State University, CA, USA “A comprehensive and sweeping overview of turtle evolution by the top experts in the field that will interest everyone curious about these unique reptiles.” Jason S. Anderson, University of Calgary, Canada “An invaluable addition to the literature that covers the full spectrum of approaches toward understanding the evolution of these noble creatures.” Ann C. Burke, Wesleyan University, CT , USA “A truly comprehensive volume that both the student of fossil turtles, as well as the general reader interested in these enigmatic creatures, will find fascinating.” Tyler Lyson, Yale University, CT, USA
Author | : Sa A. Wang |
Publisher | : Springer |
Total Pages | : 413 |
Release | : 2018-06-04 |
Genre | : Medical |
ISBN | : 3319202790 |
This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities. Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasms for all disease entities. Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms. It will provide a practical and concise yet comprehensive review.