Science Fusion draws on new materialist theory to analyze the relationship between science and literature in contemporary works of fiction, poetry, and theater from Mexico. In this deft new study, Brian Chandler examines how a range of contemporary Mexican writers “fuse” science and literature in their work to rethink what it means to be human in an age of climate change, mass extinctions, interpersonal violence, femicide, and social injustice. The authors under consideration here—including Alberto Blanco, Jorge Volpi, Ignacio Padilla, Sabina Berman, Maricela Guerrero, and Elisa Díaz Castelo—challenge traditional divisions that separate human from nonhuman, subject from object, culture from nature. Using science and literature to engage topics in biopolitics, historiography, metaphysics, ethics, and ecological crisis in the age of the Anthropocene, works of science fusion offer fresh perspectives to address present-day sociocultural and environmental issues.