This volume presents some of the most recent dramatic results of molecular, genomic, and organismal evolutionary processes. It represents analyses, experiments, observations, reviews, discussions and forecasts of evolutionary theory comprising both novel methods and results, reanalyzed and reviewed data sets based on comparative, experimental, and theoretical studies utilizing model organisms across phylogeny, including bacteria, fungi, plants, animals and humans. It elucidates the revolution in molecular biology that ushered in our understanding of the evolutionary process over time and space. The topics discussed include major problems of evolutionary theory concerning origins, phylogeny, relative importance of evolutionary forces, structure and function, adaptation and speciation in space and time in changing and stressful environments. A major emerging generalization is the nonrandomness of genome structure highlighting the importance of natural selection as a major organizing evolutionaryforce not only at the phenotypic level, but most importantly at the interlinked genotypic molecular level. The integration between the molecular