Development Of Novel Optics And Analysis Tools For Enhancing Biomedical Imaging By Coherent Raman Scattering
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Stimulated Raman Scattering Microscopy
| Author | : Ji-Xin Cheng |
| Publisher | : Elsevier |
| Total Pages | : 610 |
| Release | : 2021-12-08 |
| Genre | : Science |
| ISBN | : 0323851584 |
Stimulated Raman Scattering Microscopy: Techniques and Applications describes innovations in instrumentation, data science, chemical probe development, and various applications enabled by a state-of-the-art stimulated Raman scattering (SRS) microscope. Beginning by introducing the history of SRS, this book is composed of seven parts in depth including instrumentation strategies that have pushed the physical limits of SRS microscopy, vibrational probes (which increased the SRS imaging functionality), data science methods, and recent efforts in miniaturization. This rapidly growing field needs a comprehensive resource that brings together the current knowledge on the topic, and this book does just that. Researchers who need to know the requirements for all aspects of the instrumentation as well as the requirements of different imaging applications (such as different types of biological tissue) will benefit enormously from the examples of successful demonstrations of SRS imaging in the book. Led by Editor-in-Chief Ji-Xin Cheng, a pioneer in coherent Raman scattering microscopy, the editorial team has brought together various experts on each aspect of SRS imaging from around the world to provide an authoritative guide to this increasingly important imaging technique. This book is a comprehensive reference for researchers, faculty, postdoctoral researchers, and engineers. Includes every aspect from theoretic reviews of SRS spectroscopy to innovations in instrumentation and current applications of SRS microscopy Provides copious visual elements that illustrate key information, such as SRS images of various biological samples and instrument diagrams and schematics Edited by leading experts of SRS microscopy, with each chapter written by experts in their given topics
Coherent Raman Scattering Microscopy
| Author | : Ji-Xin Cheng |
| Publisher | : CRC Press |
| Total Pages | : 603 |
| Release | : 2016-04-19 |
| Genre | : Science |
| ISBN | : 1439867666 |
The First Book on CRS MicroscopyCompared to conventional Raman microscopy, coherent Raman scattering (CRS) allows label-free imaging of living cells and tissues at video rate by enhancing the weak Raman signal through nonlinear excitation. Edited by pioneers in the field and with contributions from a distinguished team of experts, Coherent Raman Sc
Coherent Raman Scattering Microscopy
| Author | : Ji-Xin Cheng |
| Publisher | : CRC Press |
| Total Pages | : 610 |
| Release | : 2018-04-16 |
| Genre | : |
| ISBN | : 9781138199521 |
The First Book on CRS Microscopy Compared to conventional Raman microscopy, coherent Raman scattering (CRS) allows label-free imaging of living cells and tissues at video rate by enhancing the weak Raman signal through nonlinear excitation. Edited by pioneers in the field and with contributions from a distinguished team of experts, Coherent Raman Scattering Microscopy explains how CRS can be used to obtain a point-by-point chemical map of live cells and tissues. In color throughout, the book starts by establishing the foundation of CRS microscopy. It discusses the principles of nonlinear optical spectroscopy, particularly coherent Raman spectroscopy, and presents the theories of contrast mechanisms pertinent to CRS microscopy. The text then provides important technical aspects of CRS microscopy, including microscope construction, detection schemes, and data analyses. It concludes with a survey of applications that demonstrate how CRS microscopy has become a valuable tool in biomedicine. Due to its label-free, noninvasive examinations of living cells and organisms, CRS microscopy has opened up exciting prospects in biology and medicine--from the mapping of 3D distributions of small drug molecules to identifying tumors in tissues. An in-depth exploration of the theories, technology, and applications, this book shows how CRS microscopy has impacted human health and will deepen our understanding of life processes in the future.
Neurophotonics and Biomedical Spectroscopy
| Author | : Robert R. Alfano |
| Publisher | : William Andrew |
| Total Pages | : 612 |
| Release | : 2018-11-22 |
| Genre | : Technology & Engineering |
| ISBN | : 0323480683 |
Neurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of diseases and other conditions, including pre-malignancy, cancer, Alzheimer's disease, tissue and cell response to therapeutic intervention, unintended injury and laser energy deposition. The book then highlights research in neurophotonics that investigates single and multi-photon excitation optical signatures of normal/diseased nerve tissues and in the brain, providing a better understanding of the underlying biochemical and structural changes of tissues and cells that are responsible for the observed spectroscopic signatures. Topics cover a wide array of well-established UV, visible, NIR and IR optical and spectroscopic techniques and novel approaches to diagnose tissue changes, including: label free in vivo and ex vivo fluorescence spectroscopy, Stoke shift spectroscopy, spectral imaging, Resonance Raman spectroscopy, multiphoton two Photon excitation, and more. - Provides an overview of the spectroscopic properties of tissue and tissue-light interaction, describing techniques to exploit these properties in imaging - Explores the potential and significance of molecule-specific imaging and its capacity to reveal vital new information on nanoscale structures - Offers a concise overview of different spectroscopic methods and their potential benefits for solving diagnostic and therapeutic problems
Raman Spectroscopy In Human Health And Biomedicine
| Author | : Hidetoshi Sato |
| Publisher | : World Scientific |
| Total Pages | : 657 |
| Release | : 2023-09-21 |
| Genre | : Science |
| ISBN | : 9811264627 |
Since the inelastic scattering of light was predicted nearly 100 years ago, Raman spectroscopy has become a mainstay of characterization techniques, with applications in a vast array of fields from chemistry to materials science and nanotechnology, from forensics to geology and art. More recently, it has found usage in the life sciences, and this book hereby outlines the state-of-the-art advances in applications of Raman spectroscopy to human health and biomedicine. It covers a wide range of human health science including medicine (especially cancer), physiology, biological molecules, pharmaceutical science, cells, viruses, microorganisms, and food science. Another highlight is that it describes recent progress on various Raman techniques such as surface-enhanced Raman scattering, tip-enhanced Raman scattering, non-linear Raman spectroscopy, Raman microscopy, and Raman imaging. Novel spectral analysis methods such as chemometrics are also prominently discussed.
Application and Miniaturization of Linear and Nonlinear Raman Microscopy for Biomedical Imaging
| Author | : Richa Mittal |
| Publisher | : |
| Total Pages | : 104 |
| Release | : 2014 |
| Genre | : |
| ISBN | : 9781321021585 |
Current diagnostics for several disorders rely on surgical biopsy or evaluation of ex vivo bodily fluids, which have numerous drawbacks. We evaluated the potential for vibrational techniques (both linear and nonlinear Raman) as a reliable and noninvasive diagnostic tool. Raman spectroscopy is an optical technique for molecular analysis that has been used extensively in various biomedical applications. Based on demonstrated capabilities of Raman spectroscopy we evaluated the potential of the technique for providing a noninvasive diagnosis of mucopolysaccharidosis (MPS). These studies show that Raman spectroscopy can detect subtle changes in tissue biochemistry. In applications where sub-micrometer visualization of tissue compositional change is required, a transition from spectroscopy to high quality imaging is necessary. Nonlinear vibrational microscopy is sensitive to the same molecular vibrations as linear Raman, but features fast imaging capabilities. Coherent Raman scattering when combined with other nonlinear optical (NLO) techniques (like two-photon excited fluorescence and second harmonic generation) forms a collection of advanced optical techniques that provide noninvasive chemical contrast at submicron resolution. This capability to examine tissues without external molecular agents is driving the NLO approach towards clinical applications. However, the unique imaging capabilities of NLO microscopy are accompanied by complex instrument requirements. Clinical examination requires portable imaging systems for rapid inspection of tissues. Optical components utilized in NLO microscopy would then need substantial miniaturization and optimization to enable in vivo use. The challenges in designing compact microscope objective lenses and laser beam scanning mechanisms are discussed. The development of multimodal NLO probes for imaging oral cavity tissue is presented. Our prototype has been examined for ex vivo tissue imaging based on intrinsic fluorescence and SHG contrast. These studies show a potential for multiphoton compact probes to be used for real time imaging in the clinic.
Multimodal Optical Diagnostics of Cancer
| Author | : Valery V. Tuchin |
| Publisher | : Springer Nature |
| Total Pages | : 605 |
| Release | : 2020-10-23 |
| Genre | : Medical |
| ISBN | : 3030445941 |
This book provides an in-depth description and discussion of different multi-modal diagnostic techniques for cancer detection and treatment using exact optical methods, their comparison, and combination. Coverage includes detailed descriptions of modern state of design for novel methods of optical non-invasive cancer diagnostics; multi-modal methods for earlier cancer diagnostic enhancing the probability of effective cancer treatment; modern clinical trials with novel methods of clinical cancer diagnostics; medical and technical aspects of clinical cancer diagnostics, and long-term monitoring. Biomedical engineers, cancer researchers, and scientists will find the book to be an invaluable resource. Introduces optical imaging strategies; Focuses on multimodal optical diagnostics as a fundamental approach; Discusses novel methods of optical non-invasive cancer diagnostics.
Optical Spectroscopy And Imaging For Cancer Diagnostics: Fundamentals, Progress, And Challenges
| Author | : Noureddine Melikechi |
| Publisher | : World Scientific |
| Total Pages | : 559 |
| Release | : 2023-01-06 |
| Genre | : Technology & Engineering |
| ISBN | : 981125897X |
This is an interdisciplinary book that presents the applications of novel laser spectroscopy and imaging techniques for the detection of cancers recently developed by some of the world's most renown researchers. The book consists of three parts and a total of 16 chapters. Each chapter is written by leading experts who are actively seeking to develop novel spectroscopic and analytical methods for cancer detection and diagnosis.In Part I, the authors present fundamentals on optics, atoms and molecules, biophysics, cancer and machine learning. These chapters are intended for those who are not experts in the field but wish to learn about fundamentals' aspects of some of the key topics that are addressed in this book. Particular attention has been given to providing key references for those who wish to go further into the fundamental aspects of atoms and molecules, light-matter interaction, optical instrumentation, machine learning and cancer.In Part II, the authors present key applications of various laser spectroscopic methods in cancer diagnosis. They have provided recent progress in cancer diagnostics obtained by combining laser spectroscopy and machine learning for the analysis of the spectra acquired from biomedical tissues and biofluids.In Part III, the authors present chapters that discuss key developments in the applications of various laser imaging techniques for cancer detection.This is one of the few books that addresses cancer detection and diagnosis using laser spectroscopic and imaging tools with an eye on providing the reader the scientific tools, including machine learning ones.
Coherent Anti-Stokes Raman Scattering (CARS) Microscopy for Bioimaging
| Author | : Jian Lin |
| Publisher | : LAP Lambert Academic Publishing |
| Total Pages | : 120 |
| Release | : 2012 |
| Genre | : |
| ISBN | : 9783659289132 |
Coherent anti-Stokes Raman scattering (CARS) microscopy is a nonlinear Raman imaging technique that has received great attention for biological and biomedical imaging due to its ability of real-time, nonperturbative chemical mapping of live unstained cells and tissue based on molecular vibrations. However, the strong nonresonant background reduces the image contrast and sensitivity of CARS imaging. Its spatial resolution is limited by light diffraction. This research has systematically studied the near-field (NF) effects of nanoparticle sizes, orientations, polarization of excitations on NF-CARS imaging using FDTD method, and has developed a radially polarized near-field tip-enhanced (TE) CARS system for high-resolution vibrational imaging and a unique annular-aperture detection scheme for suppressing the solvent background. The novel TE-CARS technique and the multimodal nonlinear optical microscopy imaging platform developed in this work have great potential to provide new insights into better understanding of morphological, biochemical and biomolecular changes associated with tissue and cell pathologic transformation at the tissue, cellular and molecular levels without labeling.
