Development Of In Tether Carbon Chiral Center Induced Helical Peptide
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| Author | : Kuan Hu |
| Publisher | : Springer Nature |
| Total Pages | : 113 |
| Release | : 2021-01-26 |
| Genre | : Science |
| ISBN | : 9813366133 |
This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.
| Author | : |
| Publisher | : |
| Total Pages | : 804 |
| Release | : 2005 |
| Genre | : Dissertations, Academic |
| ISBN | : |
| Author | : Timothy Deming |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 184 |
| Release | : 2012-01-10 |
| Genre | : Technology & Engineering |
| ISBN | : 3642271391 |
Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-
| Author | : Joost N. H. Reek |
| Publisher | : John Wiley & Sons |
| Total Pages | : 211 |
| Release | : 2010-02-02 |
| Genre | : Science |
| ISBN | : 9783527629718 |
This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC. Authored by the "Who's Who" of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and perspectives. All set to become the standard text in the field, this one-stop reference contains everything organic, catalytic, polymer, physical and biochemists need to know.
| Author | : The Nuclear Magnetic Resonance Society of Japan |
| Publisher | : Springer |
| Total Pages | : 634 |
| Release | : 2017-11-23 |
| Genre | : Science |
| ISBN | : 9811059667 |
This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.
| Author | : American Chemical Society |
| Publisher | : |
| Total Pages | : 990 |
| Release | : 2003 |
| Genre | : Chemistry |
| ISBN | : |
| Author | : Robert H. Grubbs |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1639 |
| Release | : 2015-05-26 |
| Genre | : Science |
| ISBN | : 3527334246 |
Covering the complete breadth of the olefin metathesis reaction. The second edition of the ultimate reference in this field is completely updated and features more than 80% new content, with the focus on new developments in the field, especially in industrial applications. No other book covers the topic in such a comprehensive manner and in such high quality, and this new edition retains the three-volume format: Catalyst Development, Applications in Organic Synthesis and Polymer Synthesis. Edited by a Nobel laureate in the field, and with a list of contributors that reads like a "Who's-Who" of metathesis, this is an indispensable one-stop reference for organic, polymer and industrial chemists, as well as chemists working with organometallics. Individual volumes also available separately to purchase Volume 1: Catalyst Development - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339485.html Volume 2: Applications in Organic Synthesis - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339493.html Volume 3: Polymer Synthesis - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339507.html
| Author | : David S. Goodsell |
| Publisher | : John Wiley & Sons |
| Total Pages | : 351 |
| Release | : 2004-04-16 |
| Genre | : Science |
| ISBN | : 0471469580 |
Discussions of the basic structural, nanotechnology, and system engineering principles, as well as an introductory overview of essential concepts and methods in biotechnology, will be included. Text is presented side-by-side with extensive use of high-quality illustrations prepared using cutting edge computer graphics techniques. Includes numerous examples, such applications in genetic engineering. Represents the only available introduction and overview of this interdisciplinary field, merging the physical and biological sciences. Concludes with the authors' expert assessment of the future promise of nanotechnology, from molecular "tinkertoys" to nanomedicine. David Goodsell is author of two trade books, Machinery of Life and Our Molecular Nature, and Arthur Olson is the world's leader in molecular graphics and nano-scale representation.
| Author | : Xiao-Feng Wu |
| Publisher | : John Wiley & Sons |
| Total Pages | : 552 |
| Release | : 2018-01-03 |
| Genre | : Science |
| ISBN | : 352734196X |
Written by highly renowned and experienced authors, this is the only reference on the application of solvents as reagents. Clearly structured, the text describes various methods for the activation and reaction of these small molecules, highlighting the synthetic opportunities as well as process-oriented advantages. To this end, all relevant types of solvents are covered separately and emphasized with numerous synthetic examples, while taking care to explain applications so as to avoid undesired side reactions. The result is a unique resource for every synthetic chemist and reaction engineer in industry and academia working on the methodical optimization of synthetic transformations.
| Author | : James D. Morrison |
| Publisher | : |
| Total Pages | : 492 |
| Release | : 1980 |
| Genre | : Chemical reactions |
| ISBN | : |
