Synthesis of Conformationally Constrained Proline-lysine Analog and Studies Towards the Synthesis of Iboga Alkaloids Employing a Novel Diels-alder Strategy

Synthesis of Conformationally Constrained Proline-lysine Analog and Studies Towards the Synthesis of Iboga Alkaloids Employing a Novel Diels-alder Strategy
Author: Rakesh R. Ganorkar
Publisher:
Total Pages: 224
Release: 2006
Genre:
ISBN:

The two main projects for this thesis were: the synthesis of proline templated lysine and the studies towards the total synthesis of the naturally occurring iboga alkaloids, viz., 3-hydroxy-3,4-secocoronaridine and catharanthine. The poly-L-proline type I1 (PPII) secondary structure is a critical recognition element in mediating protein-protein interactions and thereby regulating cellular signaling. Therefore the design of PPII mimics is highly desirable, as they can potentially be used as chemotherapeutic agents. These PPII mimics can be obtained from peptides constructed of proline templated amino acids. In our ongoing efforts towards the design and synthesis of such PPII mimics, we have synthesized the 4-substituted proline templated lysine in 8 easy steps starting from commercially available materials, with an overall yield of more than 25%. The key feature of our strategy included a one pot stereoselective reduction of a double bond, accompanying the reduction of a nitrile group to the corresponding amine with simultaneous protection of the newly generated primary amine. Proper selection of protecting groups and the sequence of the reactions were instrumental towards the synthesis. This unnatural amino acid was then incorporated into a peptide chain and PKG binding studies were conducted.

Journal

Journal
Author: American Chemical Society
Publisher:
Total Pages: 1448
Release: 2002
Genre: Chemistry
ISBN:

Boron Nitride Nanotubes in Nanomedicine

Boron Nitride Nanotubes in Nanomedicine
Author: Gianni Ciofani
Publisher: William Andrew
Total Pages: 248
Release: 2016-04-26
Genre: Technology & Engineering
ISBN: 0323389600

Boron Nitride Nanotubes in Nanomedicine compiles, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nanoparticles and their applications in biomedicine. Boron nitride nanotubes (BNNTs) represent an innovative and extremely intriguing class of nanomaterials. After introducing BNNTs and explaining their preparation and evaluation, the book shows how the physical, chemical, piezoelectric and biocompatibility properties of these nanotubes give rise to their potential uses in biomedicine. Evidence is offered (from both in vitro and in vivo investigations) for how BNNTs can be useful in biomedical and nanomedicine applications such as therapeutic applications, tissue regeneration, nanovectors for drug delivery, and intracellular nanotransducers. - Covers a range of promising biomedical BNNT applications - Provides great value not just to academics but also industry researchers in fields such as materials science, molecular biology, pharmacology, biomedical engineering, and biophysical sciences - Offers evidence for how BNNTs can be useful in biomedical and nanomedicine applications such as therapy, tissue regeneration, nanovectors for drug delivery, and intracellular nanotransducers - Incorporates, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nanoparticles and their applications in biomedicine

Peptides

Peptides
Author: Norbert Sewald
Publisher: Wiley-VCH Verlag GmbH
Total Pages: 562
Release: 2002-01-01
Genre: Science
ISBN: 9783527304059

Peptides play a decisive role in many physiological processes, whether as neurotransmitters, hormones or antibiotics. The rapid developments in peptide research over the past few decades make it almost impossible for newcomers to gain an overview. This means an easily comprehensible yet concise introduction is vital. This unique work covers all the important aspects of this wide-ranging field in one handy volume. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides, via chemical, biochemical and genetic methods of peptide synthesis, right up to peptide libraries, peptide design and their role in drug research. Yet this book offers much more than a mere overview of the latest level of research. An encyclopedic appendix with valuable data on more than 500 biological relevant peptides and proteins, a comprehensive register and details of further literature references make this the ideal reference for all questions regarding peptide research. For newcomers and specialists alike. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides.

Enantioselective Chemical Synthesis

Enantioselective Chemical Synthesis
Author: Elias J. Corey
Publisher:
Total Pages: 328
Release: 2013
Genre: Science
ISBN: 9781306070645

Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field s progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules Clearly explains stereochemical synthesis in theory and practiceProvides a handy tool box for scientists wishing to understand and apply chiral chemical synthesisDescribes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages"

Peptide Applications in Biomedicine, Biotechnology and Bioengineering

Peptide Applications in Biomedicine, Biotechnology and Bioengineering
Author: Sotirios Koutsopoulos
Publisher: Woodhead Publishing
Total Pages: 655
Release: 2017-11-16
Genre: Technology & Engineering
ISBN: 0081007426

Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. - Presents a self-contained work for the field of biomedical peptides - Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering - Covers current and potential applications of biomedical peptides