Design and Synthesis of Organic Molecules Based on Molecular Recognition

Design and Synthesis of Organic Molecules Based on Molecular Recognition
Author: Georges van Binst
Publisher: Springer Science & Business Media
Total Pages: 322
Release: 2012-12-06
Genre: Science
ISBN: 3642709265

A topic for a Solvay Conference should be general enough to conform with the great tradition of previous conferences. On the other hand it should not be so broad that it can not be covered during the limited time of the conference. After discussion of several such topics, "Design and Synthesis of Organic Molecules Based on Molecular Recognition" was chosen. According to Albert Einstein we live in an era of perfect methods and confused aims. For example in organic chemistry the known synthetic methods allow us to prepare an astronomical number of compounds; the gap between the possible and the relevant becomes larger every day. After discovery and classification of the main types of reactions, the study of the selectivity of reactions becomes of paramount importance. One can learn quite a lot from Nature, which uses molecular recognition to achieve selec tivity in a degree so far unattainable by mere mortals. To analyze the structural features applied by Nature, to accomplish high molecular recog nition, and to simulate these features by synthesis have recently become therefore favorite occupations of chemists. The purpose of this conference was to bring together two groups, the analysts and the syntheticists, to discuss the present status of the knowledge. This monograph contains the chairman's introduction in which he has summarized the main points at issue and the contributions of the renowned scientists who participated. The organizers hope that it will stimulate further research in this fascinating field.

Rates and Equilibria of Organic Reactions as Treated by Statistical, Thermodynamic, and Extrathermodynamic Methods

Rates and Equilibria of Organic Reactions as Treated by Statistical, Thermodynamic, and Extrathermodynamic Methods
Author: John E. Leffler
Publisher: Courier Corporation
Total Pages: 500
Release: 1989-01-01
Genre: Science
ISBN: 9780486660684

Graduate-level text stresses extrathermodynamic approach to quantitative prediction and constructs a logical framework that encompasses and classifies all known extrathermodynamic relationships. Numerous figures and tables. Author and Subject Indexes.

Organic Synthesis and Molecular Engineering

Organic Synthesis and Molecular Engineering
Author: Mogens Brøndsted Nielsen
Publisher: John Wiley & Sons
Total Pages: 462
Release: 2013-10-18
Genre: Science
ISBN: 1118736486

The theory, methods, and practices needed to build molecules and supramolecular systems Using a synthetic approach to organic materials chemistry, this book sets forth tested and proven methods and practices that make it possible to engineer organic molecules offering special properties and functions. Throughout the book, plenty of real-world examples demonstrate the countless possibilities of creating one-of-a-kind molecules and supramolecular systems to support a broad range of applications. The book explores applications in both materials and bioorganic chemistry, including molecular electronics, energy storage, sensors, nanomedicine, and enzyme engineering. Organic Synthesis and Molecular Engineering consists of fourteen chapters, each one contributed by one or more leading international experts in the field. The contributions are based on a thorough review and analysis of the current literature as well as the authors' firsthand experience in the lab engineering new organic molecules. Designed as a practical lab reference, the book offers: Tested and proven synthetic approaches to organic materials chemistry Methods and practices to successfully engineer functionality into organic molecules Explanations of the principles and concepts underlying self-assembly and supramolecular chemistry Guidance in selecting appropriate structural units used in the design and synthesis of functional molecules and materials Coverage of the full range of applications in materials and bioorganic chemistry A full chapter on graphene, a new topic generating intense research Organic Synthesis and Molecular Engineering begins with core concepts, molecular building blocks, and synthetic tools. Next, it explores molecular electronics, supramolecular chemistry and self-assembly, graphene, and photoresponsive materials engineering. In short, it offers everything researchers need to fully grasp the underlying theory and then build new molecules and supramolecular systems.

Beyond the Molecular Frontier

Beyond the Molecular Frontier
Author: National Research Council
Publisher: National Academies Press
Total Pages: 238
Release: 2003-03-19
Genre: Science
ISBN: 0309168392

Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.

Design and Synthesis of Organic Molecules Based on Molecular Recognition

Design and Synthesis of Organic Molecules Based on Molecular Recognition
Author: Georges van Binst
Publisher: Springer
Total Pages: 316
Release: 2011-12-08
Genre: Science
ISBN: 9783642709272

A topic for a Solvay Conference should be general enough to conform with the great tradition of previous conferences. On the other hand it should not be so broad that it can not be covered during the limited time of the conference. After discussion of several such topics, "Design and Synthesis of Organic Molecules Based on Molecular Recognition" was chosen. According to Albert Einstein we live in an era of perfect methods and confused aims. For example in organic chemistry the known synthetic methods allow us to prepare an astronomical number of compounds; the gap between the possible and the relevant becomes larger every day. After discovery and classification of the main types of reactions, the study of the selectivity of reactions becomes of paramount importance. One can learn quite a lot from Nature, which uses molecular recognition to achieve selec tivity in a degree so far unattainable by mere mortals. To analyze the structural features applied by Nature, to accomplish high molecular recog nition, and to simulate these features by synthesis have recently become therefore favorite occupations of chemists. The purpose of this conference was to bring together two groups, the analysts and the syntheticists, to discuss the present status of the knowledge. This monograph contains the chairman's introduction in which he has summarized the main points at issue and the contributions of the renowned scientists who participated. The organizers hope that it will stimulate further research in this fascinating field.

Comprehensive Supramolecular Chemistry II

Comprehensive Supramolecular Chemistry II
Author: George W. Gokel
Publisher: Elsevier
Total Pages: 4627
Release: 2017-06-22
Genre: Science
ISBN: 0128031999

Comprehensive Supramolecular Chemistry II, Second Edition, Nine Volume Set is a ‘one-stop shop’ that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996

Supramolecular Chemistry - Fundamentals and Applications

Supramolecular Chemistry - Fundamentals and Applications
Author: Katsuhiko Ariga
Publisher: Springer Science & Business Media
Total Pages: 215
Release: 2006-08-02
Genre: Science
ISBN: 3540261850

The fundamentals of "supramolecular chemistry" to the latest developments on the subject are covered by this book. It sets out to explain the topic in a relatively easy way. The basic concepts of molecular recognition chemistry are included. Molecules with fascinating shapes and functions such as fullerenes, carbon nanotubes, dendrimers, rotaxane, and catenane, and molecular assemblies are also explained. Thereafter applications of supermolecules to nanotechnology are introduced with many examples of molecular devices. The last part of the book describes biological supermolecules and their mimics. Though simply explained undergraduate and graduate students in Chemistry will be able to use aspects of this work as an advanced textbook.

Drug-like Properties: Concepts, Structure Design and Methods

Drug-like Properties: Concepts, Structure Design and Methods
Author: Li Di
Publisher: Elsevier
Total Pages: 549
Release: 2010-07-26
Genre: Science
ISBN: 0080557619

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Synthetic Receptors for Biomolecules

Synthetic Receptors for Biomolecules
Author: Bradley D. Smith
Publisher: Royal Society of Chemistry
Total Pages: 466
Release: 2015-07-10
Genre: Science
ISBN: 1849739714

Synthetic receptor molecules, molecules that mimic antibody recognition, are widely used for developing drug leads; drug delivery vehicles; imaging agents; sensing agents; capture agents and separation systems. Synthetic Receptors for Biomolecules covers the most effective synthetic receptors for each major class of biomolecules within the context of specific applications. The book starts with an introduction to the applications of synthetic receptors for biomolecules and their design and synthesis for biomolecule recognition. Dedicated chapters then cover synthetic receptors for the key biomolecules including inorganic cations; small organic and inorganic anions; carbohydrates; nucleosides/nucleotides; oligonucleotides; amino acids and peptides; protein surfaces as well as non-polar and polar lipids; Each chapter follows the same systematic format of (a) chemical structures and physical properties of the biomolecule, (b) biological recognition of the biomolecule, (c) synthetic receptors for the biomolecule, (d) future directions and challenges. Edited by a leader in the field, the book is written in an accessible style for readers new to supramolecular chemistry or for those looking for synthetic receptors.

Principles of Molecular Recognition

Principles of Molecular Recognition
Author: A.D. Buckingham
Publisher: Springer Science & Business Media
Total Pages: 232
Release: 1993-09-30
Genre: Science
ISBN: 9780751401257

The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan. Although molecular recognition is necessarily microscopic in origin, its consequences are de facto macroscopic. Accordingly, a text that starts with intermolecular interactions between simple molecules and builds to a discussion of molecular recognition involving larger scale systems is timely. This book was planned with such a development in mind. The book begins with an elementary but rigorous account of the various types of forces between molecules. Chapter 2 is concerned with the hydrogen bond between pairs of simple molecules in the gas phase, with particular reference to the preferred relative orientation of the pair and the ease with which this can be distorted. This microscopic view continues in chapter 3 wherein the nature of interactions between solute molecules and solvents or between two or more solutes is examined from the experimental standpoint, with various types of spectroscopy providing the probe of the nature of the interactions. Molecular recognition is central to the catalysis of chemical reactions, especially when bonds are to be broken and formed under the severe con straint that a specific configuration is to result, as in the production of enan tiotopically pure compounds. This important topic is considered in chapter 4.