The concept of decision making has acquired a new dimension in the modern world of business. It is interpreted in various ways. Some consider it as an instrument of strategy, with tools and methods to implement the company's targets. Others regard it as a shift toward a more culture-centric or culture-oriented management. But it is mostly a method of adaptation to the new realities of the market - a market that has multiple forms and numerous cultural characteristics. Decision-making is also about the adoption of new skills in order to understand the evolution of the market. Thus, decision makers adopt their organization's philosophy, and apply the appropriate policies to solve issues. There are many different criteria that should be taken into consideration when defining the term ''decision-making'', including culture, which is one of the main factors having a significant influence given the current business environment. The objective of this study is to cast the light on this process through the prism of multinational organizations. The concept evolves in different spheres and business activities. Our methodology consists of a qualitative study on two multinationals; Transmed and PWC, the results of which reveal that culture has a positive influence in the process of decision-making.