Cytomegalovirus Protocols
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Author | : John Sinclair |
Publisher | : Springer Science & Business Media |
Total Pages | : 186 |
Release | : 2008-02-01 |
Genre | : Medical |
ISBN | : 1592592449 |
John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus (CMV) biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in human infectious diseases and their emergent therapies.
Author | : Ann Arvin |
Publisher | : Cambridge University Press |
Total Pages | : 1325 |
Release | : 2007-08-16 |
Genre | : Medical |
ISBN | : 1139461648 |
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author | : Associate Professor in International Communication Sociology and Cultural Studies in the Faculty of Arts John Sinclair |
Publisher | : |
Total Pages | : 187 |
Release | : 2014-05-14 |
Genre | : |
ISBN | : 9780585235677 |
In Cytomegalovirus Protocols (CMV), John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a powerful collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in the pathogenesis of human infectious diseases as well as their emergent therapies.
Author | : Andrew D. Yurochko |
Publisher | : Humana |
Total Pages | : 468 |
Release | : 2022-02-23 |
Genre | : Medical |
ISBN | : 9781071611135 |
This new edition explores and provides an update on the biology and pathogenesis of human cytomegalovirus infection. Modern techniques that are currently being utilized to investigate the molecular aspects of viral infection, as well as how these new research studies are leading to new approaches to mitigate disease, are also provided. Given the key role the virus plays in significant acute and chronic human disease in all stages of life, from newborns to seniors, the need for clear methodologies to further explore the biology of HCMV infection and mitigation strategies is readily apparent. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Human Cytomegaloviruses: Methods and Protocols, Second Edition serves as an ideal scientific reference for basic and clinical scientists and medical personnel on the modern understanding of the pathobiology of the virus, and the approaches, techniques, and models to study human cytomegalovirus infection and disease.
Author | : American Academy of Pediatrics |
Publisher | : |
Total Pages | : 440 |
Release | : 2007 |
Genre | : Health & Fitness |
ISBN | : 9781581102475 |
Based on key content from Red Book: 2006 Report of the Committee on Infectious Diseases, 27th Edition, the new Red Bookr Atlas is a useful quick reference tool for the clinical diagnosis and treatment of more than 75 of the most commonly seen pediatric infectious diseases. Includes more than 500 full-color images adjacent to concise diagnostic and treatment guidelines. Essential information on each condition is presented in the precise sequence needed in the clinical setting: Clinical manifestations, Etiology, Epidemiology, Incubation period, Diagnostic tests, Treatment
Author | : Jane Meschan Foy |
Publisher | : |
Total Pages | : 0 |
Release | : 2016-03-31 |
Genre | : Children |
ISBN | : 9781581109665 |
The definitive manual of pediatric medicine - completely updated with 75 new chapters and e-book access.
Author | : James K. McDougall |
Publisher | : Springer Science & Business Media |
Total Pages | : 280 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642749801 |
Named for the enlarged, inclusion-bearing cells characteristic of infection by these viruses, cytomegaloviruses present a significant challenge to both microbiologist and immunologist. Although most primary infections in humans are subclinical, cytomegalovirus can be associated with a wide spectrum of disease, particularly when infection occurs in the immuno compromised individual or as a result of congenital or perinatal infection. Although reinfection with cytomegalovirus has been demonstrated, most recurrent and persistent infections result from the reactivation of latent virus. Cytomegaloviruses, like other members of the Herpesviridae family, have the capacity to establish latency after a primary infection but the mechanisms for establishing the nonreplicating but reactivat able state have not been defined. The factors responsible for the spectrum of manifestations of cytomegalovirus infection are largely undetermined but host immunological function, route of infection, and size of inoculum all contribute to the extent and severity of disease. Cytomegaloviruses have the largest genomes in the herpes virus family, approximately 240 kilo base pairs, providing a potential coding capacity for more than 200 proteins of which less than one-fourth have been mapped and described. There are many similarities to other herpes viruses in genome structure and gene expression; for example, three temporal classes of genes can be identified as rx (immediate-early), f3 (early), and y (late) products. The first five chapters of this volume review and describe recent developments in understanding the trans cription and regulation of these gene classes.
Author | : Nathalie Künzle |
Publisher | : |
Total Pages | : 9 |
Release | : 2000 |
Genre | : |
ISBN | : |
Author | : Maria Paolo Landini |
Publisher | : |
Total Pages | : 396 |
Release | : 1991 |
Genre | : Medical |
ISBN | : |
The cytomegalovirus is not only scientifically fascinating, but responsible for significant morbidity and mortality throughout the world. The Third International CMV Workshop provided the forum for a comprehensive analysis of the state of the art in the various fields of CMV research. This text contains the overviews and oral communications presented, evenly distributed between basic science and clinical sessions. Several up-to-date short reviews appear and each chapter is written by a leading expert in that field. Some subjects covered include new information on genome organization deduced from the complete nucleotide sequence, the clinical importance of CMV from classic diseases to novel associations, and virus-host-cell and CMV-HIV interactions.
Author | : David W. Kimberlin |
Publisher | : |
Total Pages | : 0 |
Release | : 2015-05 |
Genre | : Children |
ISBN | : 9781581109269 |
"The AAP's authoritative guide to the manifestations, etiology, epidemiology, diagnosis, and treatment of more than 200 childhood conditions." -- Provided by publisher.