Cytochrome P450 1991 716 P Il 24 Cm Methods In Enzymology 206
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Cytochrome P450
| Author | : Paul R. Ortiz de Montellano |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 702 |
| Release | : 2007-02-05 |
| Genre | : Medical |
| ISBN | : 0387274472 |
Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
| Author | : Eugene G. Hrycay |
| Publisher | : Springer |
| Total Pages | : 376 |
| Release | : 2015-05-22 |
| Genre | : Medical |
| ISBN | : 3319160095 |
This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Toxicological Profile for Polycyclic Aromatic Hydrocarbons
| Author | : |
| Publisher | : |
| Total Pages | : 500 |
| Release | : 1995 |
| Genre | : Polycyclic aromatic hydrocarbons |
| ISBN | : |
Modern Biooxidation
| Author | : Rolf D. Schmid |
| Publisher | : John Wiley & Sons |
| Total Pages | : 318 |
| Release | : 2007-09-24 |
| Genre | : Science |
| ISBN | : 3527611533 |
Filling a gap in the literature, leading expert editors and top international authors present the field of biooxidation from an academic and industrial point of view, taking many examples from modern pharmaceutical research. Topics range from the application of different monooxygenases to applications in the pharmaceutical industry, making this volume of high interest not only for those working in biotechnology but also for organic synthetic chemists, among others.
Mammalian Cytochromes P 450
| Author | : F. Peter Guengerich |
| Publisher | : CRC-Press |
| Total Pages | : 214 |
| Release | : 2000-12-01 |
| Genre | : Science |
| ISBN | : 9780849366734 |
Predictive ADMET
| Author | : Jianling Wang |
| Publisher | : John Wiley & Sons |
| Total Pages | : 604 |
| Release | : 2014-02-28 |
| Genre | : Medical |
| ISBN | : 1118783409 |
This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
