Syntax refers both to the structure of sentences and the underlying combinatorial capacity to generate this structure. For some time, neurolinguistic research on syntax was heavily influenced by theoretical linguistic approaches, which characterize in detail the nature of syntactic representations. A rough consensus has been that the primary region supporting syntax is Broca’s area, and that syntactic deficits in aphasia exist primarily due to damage or degeneration of this region, commonly occurring in Broca’s aphasia and nonfluent/agrammatic PPA. With respect to temporal dynamics of syntactic processing, neurophysiological research on syntax focused on specific event-related potentials such as the ELAN and P600, thought to index phrase structure building and syntactic reanalyses. However, the research landscape has changed substantially in the last several years with new methodologies and theoretical perspectives, and there is little consensus on the neurobiological foundations of syntax or the role of linguistic theory in guiding research. The goal of this Research Topic is to reassess our understanding of syntax and the brain in light of these developments. Specifically, it is designed to address the following set of major questions: