Creatine Kinase and Brain Energy Metabolism
Author | : Téa Kekelidze |
Publisher | : IOS Press |
Total Pages | : 204 |
Release | : 2003 |
Genre | : |
ISBN | : 9781586032333 |
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Author | : Téa Kekelidze |
Publisher | : IOS Press |
Total Pages | : 204 |
Release | : 2003 |
Genre | : |
ISBN | : 9781586032333 |
Author | : H. Lang |
Publisher | : Springer Science & Business Media |
Total Pages | : 334 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642680410 |
No one has counted the enzymes in the human organism, and probably their profuse number can only be estimated from the restrictions the finite mass of genetic material imposes. Still, nu merous catalytic activities have been identified and investigated for their clinical relevance. After one century of such research, surprisingly, only a handful of enzymes has survived the stern trial of clinical application to find regular medical use. Dis regarding genetic defects, most of the diagnostically used en zymes participate in metabolic conversions fundamental to life: the utilization, transfer or fixation of vital nutrients or of cheJ,llical energy. Creatine kinase is central to the function of the mitochond rion, the cellular power generator. The wider distribution of this enzyme is linked to tissues whose physiology crucially relies on an adaptable supply of energy, notably skeletal muscle, the brain, and the heart. Just as these three tissues vary in their pre ference for different energy sources, each produces a different isoenzyme of creatine kinase. Accordingly, the finding of elevat ed creatine kinase activity in blood can lead to a variety of interpretations, but in practice the diagnosis of acute myocardial infarction is the major consideration.
Author | : Gajja S. Salomons |
Publisher | : Springer Science & Business Media |
Total Pages | : 359 |
Release | : 2007-10-16 |
Genre | : Medical |
ISBN | : 1402064861 |
This volume places emphasis on the intricate interplay between creatine and creatine kinase function on one hand and proper brain function, neurodegenerative disease and/or neuroprotection on the other. The book, compiled by outstanding experts, provides a key reference summarizing the state-of-the-art in creatine and creatine kinase research. It is a must-read for understanding the links between creatine metabolism and neuroprotection as well as neurodegenerative disease.
Author | : Carla E. M. Hollak |
Publisher | : Oxford University Press |
Total Pages | : 657 |
Release | : 2016 |
Genre | : Medical |
ISBN | : 0199972133 |
As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a that topic will become a growing imperative for physicians across primary and specialized care.
Author | : Mark Paul Mattson |
Publisher | : Springer Science & Business Media |
Total Pages | : 284 |
Release | : 2002-08-31 |
Genre | : Medical |
ISBN | : 9781402071294 |
"Diet - Brain Connections fills a void between the fields of nutrition, behavior and cellular and molecular neurosciences by providing an integrated collection of articles that critically dissect the link between what we eat and how the brain develops and functions in health and disease ... This book provides an unprecedented resource for scientists in academia and government labs as well as in the pharmaceutical, nutraceutical and food industries" -- Back cover.
Author | : Valdur Saks |
Publisher | : John Wiley & Sons |
Total Pages | : 633 |
Release | : 2008-01-08 |
Genre | : Science |
ISBN | : 3527621105 |
In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.
Author | : Victor R. Preedy |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2015-08-14 |
Genre | : Medical |
ISBN | : 9789400776951 |
In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics and so on. The chapters are written by national or international experts and specialists.
Author | : Jeffrey R. Stout |
Publisher | : Springer Science & Business Media |
Total Pages | : 255 |
Release | : 2009-12-30 |
Genre | : Medical |
ISBN | : 1597455733 |
With all of the misinformation regarding the effects of creatine supplementation on health and sports performance, this book brings together the information on how creatine affects body composition, exercise performance, and health. Supported by the International Society of Sports Nutrition, this volume is timely and vital for all professionals in the field of sports nutrition.
Author | : F. Lanfranco |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 182 |
Release | : 2016-06-28 |
Genre | : Medical |
ISBN | : 3318058696 |
This book is an up-to-date, extensive overview of the effects of physical activity and training on endocrine function. It gives insights into a complex relationship by describing effects with respect to exercise performance, growth, development, and ageing. It includes discussions of the endocrine response depending on exercise mode, intensity, and duration as well as on gender, age, and fitness level. Additionally the book deals with the impact of environmental and psychological factors on endocrine level. A substantial part of Sports Endocrinology is devoted to the 'hot topic' of hormonal doping in sports. The properties of androgens, growth hormone, erythropoietin, and dietary supplements are highlighted. The use and abuse among professional and recreational athletes is discussed and specific methods of detection are presented and explained. All contributors are well-known experts in sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection, so this book is a must-read for every professional involved in the field.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 469 |
Release | : 2004-08-29 |
Genre | : Social Science |
ISBN | : 0309091594 |
The U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.