Covid 19 Severity In Obese Patients Potential Mechanisms And Molecular Targets For Clinical Intervention
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| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 101 |
| Release | : 2019-07-24 |
| Genre | : Medical |
| ISBN | : 0309485053 |
The increasing prevalence and burden of obesity transcends borders, straining populations worldwide. Data shows that 50 million girls, 74 million boys, 390 million women, and 281 million men were estimated to have obesity in 2016 (NCD-RisC, 2017). The National Academies of Sciences, Engineering, and Medicine convened a workshop on October 9, 2018 to address the status of the global obesity pandemic and discuss diverse approaches to manage this problem. Speakers examined the collective prevalence, costs, and drivers of obesity around the world using cross-cultural comparisons. Panels and group discussions emphasized the need to reduce disparities in prevention and treatment efforts and to generate new policy and system initiatives related to nutrition and physical activity worldwide. This publication summarizes the presentations and discussions from the workshop.
| Author | : Randy Q. Cron |
| Publisher | : Springer Nature |
| Total Pages | : 607 |
| Release | : 2019-09-09 |
| Genre | : Medical |
| ISBN | : 303022094X |
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
| Author | : Maciej Banach |
| Publisher | : Springer Nature |
| Total Pages | : 434 |
| Release | : 2022-12-28 |
| Genre | : Medical |
| ISBN | : 3031154789 |
This book is the first comprehensive approach on COVID-19 cardiac complications, both during the acute phase as well as in the long-COVID period. It provides an up-to-date and highly illustrated summary of the biology of SARS-CoV-2, the course of COVID-19, risk factors that worsen the disease in COVID-19 patients, clinical features of COVID-19 patients, COVID-19 cardiological complications, treatment, and prevention methods, and long-term cardiological aspects of COVID-19. Chapters provide the reader with a contemporary perspective on the emerging links between COVID-19 and cardiovascular disease. In addition, this volume discusses the clinical implications and therapeutic goals in patients with COVID-19 and cardiac complications, as well as possible therapeutic options. It also offers clear recommendations on how to manage (both non- and pharmacologically) to avoid the increased number of COVID-19 related deaths due to CVD and its risk factors. Cardiovascular Complications of COVID-19 will be the primary resource for physicians, residents, fellows, and nursed and medical students in the fields of cardiology and COVID-19/infectious diseases as well as healthcare providers that initiate preventive activities and dedicated programs.
| Author | : Gianluca Iacobellis |
| Publisher | : Oxford University Press |
| Total Pages | : 293 |
| Release | : 2009-10-08 |
| Genre | : Medical |
| ISBN | : 019954932X |
This essential book comprehensively covers the diagnosis, treatment and management of cardiovascular disease in obese patients, translating up-to-date clinical research findings into clinical practice.
| Author | : Ashfaq Ahmad |
| Publisher | : Elsevier |
| Total Pages | : 468 |
| Release | : 2022-04-26 |
| Genre | : Science |
| ISBN | : 032390436X |
Algae Biotechnology: Integrated Algal Engineering for Bioenergy, Bioremediation, and Biomedical Applications covers key applications of algae for bioenergy and how to integrate the production of biofuels with environmental, nutraceutical and biomedical processes and products. The book emphasizes cost-effective biofuels production through integrated biorefinery, combining continuous processes and various algae as feedstock to produce biofuel, bioenergy and various high value biochemicals. Novel algal culturing technologies and bioprocess engineering techniques are provided for the optimization of operational approaches for commercial-scale production, as well as to reduce the overall costs. New and existing molecular methods for genetic and metabolic engineering of algae are also presented. Furthermore, methods for the optimization of existing biochemical pathways are explained, and new pathways are introduced, in order to maximize the potential for biofuels production and related nutraceutical and biomedical co-products. This book provides an ideal roadmap for bioenergy researchers and engineers who want to incorporate valuable nutraceutical and biomedical products and environmental practices into the production of biofuels. - Addresses issues faced by the bioenergy sector and how to resolve them through the integration of algal biotechnology and engineering - Provides a guide to the efficient and cost-effective production of bioenergy, while simultaneously mitigating pollution and producing valuable nutraceutical and biomedical biproducts - Covers new and emerging approaches in integrated algal biotechnology - Offers a roadmap to their application in the production of biofuels alongside nutraceutical, biomedical, and environmental processes and products
| Author | : Boris Draznin |
| Publisher | : American Diabetes Association |
| Total Pages | : 338 |
| Release | : 2016-05-20 |
| Genre | : Medical |
| ISBN | : 1580406572 |
As the number of patients with diabetes increases annually, it is not surprising that the number of patients with diabetes who are admitted to the hospital also increases. Once in the hospital, patients with diabetes or hyperglycemia may be admitted to the Intensive Care Unit, require urgent or elective surgery, enteral or parenteral nutrition, intravenous insulin infusion, or therapies that significantly impact glycemic control (e.g., steroids). Because many clinical outcomes are influenced by the degree of glycemic control, knowledge of the best practices in inpatient diabetes management is extremely important. The field of inpatient management of diabetes and hyperglycemia has grown substantially in the last several years. This body of knowledge is summarized in this book, so it can reach the audience of hospitalists, endocrinologists, nurses and other team members who take care of hospitalized patients with diabetes and hyperglycemia.
| Author | : Malcolm K Robinson |
| Publisher | : CRC Press |
| Total Pages | : 475 |
| Release | : 2006-03-07 |
| Genre | : Medical |
| ISBN | : 1420018906 |
Although cardiovascular disease remains the leading proximate cause of death in the United States, it is now estimated that obesity may be equivalent to smoking as the leading cause of preventable death in America. In light of these statistics, this reference presents our current understanding of the epidemiology, pathology, and genetics of the obe
| Author | : Graeme Milligan |
| Publisher | : Springer |
| Total Pages | : 258 |
| Release | : 2017-02-08 |
| Genre | : Medical |
| ISBN | : 3319506935 |
This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
| Author | : Adan Chari Jirmo |
| Publisher | : Frontiers Media SA |
| Total Pages | : 142 |
| Release | : 2024-01-30 |
| Genre | : Medical |
| ISBN | : 2832543839 |
| Author | : Poonam Arora |
| Publisher | : Frontiers Media SA |
| Total Pages | : 132 |
| Release | : 2024-07-12 |
| Genre | : Science |
| ISBN | : 2832550703 |
Molecular Pharmacological approaches against lung diseases: targeted drug discovery The global burden of lung diseases is rising continuously and is a constant concern. Lung diseases of concern, including asthma, infection (pneumonia), lung cancer, abnormal build-up of fluid, swelling, and inflammation, both neoplastic and non-neoplastic diseases, are listed as the third leading cause of death by the World Health Organization. The most common disease in the lungs includes asthma, cystic fibrosis, chronic obstructive pulmonary disease etc. The respiratory issues listed here, among others, are exacerbated by environmental toxicants which directly come in contact with the lung architecture thereby causing lung pathologies resulting in the exacerbated immune response in affected patients. Biologically active molecules including small or large molecular weight compounds from natural or synthetic sources exhibit prominent pharmacological properties that impact health by modulating disease pathophysiology, and influence the ligand-receptor interactions, depending upon the pathway and their bioavailability.
