Misti volcano’s last Plinian eruption, which happened ca. 2 ka, emplaced voluminous tephra-fall, pyroclastic-flow, and lahar deposits. Arequipa, located at the foot of the volcano, has a population of over 800,000 people and growing. Misti will erupt explosively again, and it is important to understand the past Plinian eruption. This Special Paper first provides a detailed description and analysis of the lahar deposits from the 2 ka eruption and the flows that emplaced them. Because Misti is located in an arid region, the authors have also included a detailed discussion of the paleoclimate conditions that provided the water for such voluminous lahars. The authors further delineate the complete eruption sequence for the pyroclastic-flow and tephra-fall deposits, providing a narrative of the eruption progression and dynamics. Finally, the book discusses the 2 ka eruption in the context of hazards from a future Plinian eruption and provides hazards maps for the different phenomena.