DNA Topoisomerases in Cancer

DNA Topoisomerases in Cancer
Author: Milan Potmesil
Publisher: Oxford University Press, USA
Total Pages: 364
Release: 1991
Genre: Medical
ISBN:

DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy
Author: Toshiwo Andoh
Publisher: CRC Press
Total Pages: 400
Release: 1992-10-26
Genre: Medical
ISBN: 9780849349706

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.

The Eukaryotic Nucleus

The Eukaryotic Nucleus
Author: Samuel H. Wilson
Publisher: CRC Press
Total Pages: 476
Release: 1990-08-09
Genre: Science
ISBN: 9780936923338

This series provides, in two volumes, a complete and exhaustive review of the subject of the eukaryotic nucleus, the site of the DNA. The focus of the book is how the information in the DNA is transcribed, accessed and maintained.

Current Catalog

Current Catalog
Author: National Library of Medicine (U.S.)
Publisher:
Total Pages: 1628
Release: 1993
Genre: Medicine
ISBN:

First multi-year cumulation covers six years: 1965-70.

Neoplasma

Neoplasma
Author:
Publisher:
Total Pages: 788
Release: 1988
Genre: Oncology
ISBN: