Emerging Safety Science

Emerging Safety Science
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 150
Release: 2008-05-08
Genre: Medical
ISBN: 0309110122

In recent years, the costs of new drug development have skyrocketed. The average cost of developing a new approved drug is now estimated to be $1.3 billion (DiMasi and Grabowski, 2007). At the same time, each year fewer new molecular entities (NMEs) are approved. DiMasi and Grabowski report that only 21.5 percent of the candidate drugs that enter phase I clinical testing actually make it to market. In 2007, just 17 novel drugs and 2 novel biologics were approved. In addition to the slowing rate of drug development and approval, recent years have seen a number of drugs withdrawn from the market for safety reasons. According to the Government Accountability Office (GAO), 10 drugs were withdrawn because of safety concerns between 2000 and March 2006 (GAO, 2006). Finding ways to select successful drug candidates earlier in development could save millions or even billions of dollars, reduce the costs of drugs on the market, and increase the number of new drugs with improved safety profiles that are available to patients. Emerging scientific knowledge and technologies hold the potential to enhance correct decision making for the advancement of candidate drugs. Identification of safety problems is a key reason that new drug development is stalled. Traditional methods for assessing a drug's safety prior to approval are limited in their ability to detect rare safety problems. Prior to receiving U.S. Food and Drug Administration (FDA) approval, a drug will have been tested in hundreds to thousands of patients. Generally, drugs cannot confidently be linked to safety problems until they have been tested in tens of thousands to hundreds of thousands of people. With current methods, it is unlikely that rare safety problems will be identified prior to approval. Emerging Safety Science: Workshop Summary summarizes the events and presentations of the workshop.

Mapping the Travel Behavior Genome

Mapping the Travel Behavior Genome
Author: Konstadinos G. Goulias
Publisher:
Total Pages: 734
Release: 2019-10-26
Genre:
ISBN: 0128173408

Mapping the Travel Behavior Genome covers the latest research on the biological, motivational, cognitive, situational, and dispositional factors that drive activity-travel behavior. Organized into three sections, Retrospective and Prospective Survey of Travel Behavior Research, New Research Methods and Findings, and Future Research, the chapters of this book provide evidence of progress made in the most recent years in four dimensions of the travel behavior genome. These dimensions are Substantive Problems, Theoretical and Conceptual Frameworks, Behavioral Measurement, and Behavioral Analysis. Including the movement of goods as well as the movement of people, the book shows how traveler values, norms, attitudes, perceptions, emotions, feelings, and constraints lead to observed behavior; how to design efficient infrastructure and services to meet tomorrow's needs for accessibility and mobility; how to assess equity and distributional justice; and how to assess and implement policies for improving sustainability and quality of life. Mapping the Travel Behavior Genome examines the paradigm shift toward more dynamic, user-centric, demand-responsive transport services, including the "sharing economy," mobility as a service, automation, and robotics. This volume provides research directions to answer behavioral questions emerging from these upheavals. Offers a wide variety of approaches from leading travel behavior researchers from around the world Provides a complete map of the methods, skills, and knowledge needed to work in travel behavior Describes the state of the art in travel behavior research, providing key directions for future research

Contagion of Violence

Contagion of Violence
Author: National Research Council
Publisher: National Academies Press
Total Pages: 152
Release: 2013-03-06
Genre: Medical
ISBN: 0309263646

The past 25 years have seen a major paradigm shift in the field of violence prevention, from the assumption that violence is inevitable to the recognition that violence is preventable. Part of this shift has occurred in thinking about why violence occurs, and where intervention points might lie. In exploring the occurrence of violence, researchers have recognized the tendency for violent acts to cluster, to spread from place to place, and to mutate from one type to another. Furthermore, violent acts are often preceded or followed by other violent acts. In the field of public health, such a process has also been seen in the infectious disease model, in which an agent or vector initiates a specific biological pathway leading to symptoms of disease and infectivity. The agent transmits from individual to individual, and levels of the disease in the population above the baseline constitute an epidemic. Although violence does not have a readily observable biological agent as an initiator, it can follow similar epidemiological pathways. On April 30-May 1, 2012, the Institute of Medicine (IOM) Forum on Global Violence Prevention convened a workshop to explore the contagious nature of violence. Part of the Forum's mandate is to engage in multisectoral, multidirectional dialogue that explores crosscutting, evidence-based approaches to violence prevention, and the Forum has convened four workshops to this point exploring various elements of violence prevention. The workshops are designed to examine such approaches from multiple perspectives and at multiple levels of society. In particular, the workshop on the contagion of violence focused on exploring the epidemiology of the contagion, describing possible processes and mechanisms by which violence is transmitted, examining how contextual factors mitigate or exacerbate the issue. Contagion of Violence: Workshop Summary covers the major topics that arose during the 2-day workshop. It is organized by important elements of the infectious disease model so as to present the contagion of violence in a larger context and in a more compelling and comprehensive way.

Hearing Loss and Healthy Aging

Hearing Loss and Healthy Aging
Author: Tracy A. Lustig
Publisher:
Total Pages: 0
Release: 2014
Genre: Medical
ISBN: 9780309302265

Pages:1 to 25 -- Pages:26 to 50 -- Pages:51 to 75 -- Pages:76 to 100 -- Pages:101 to 125 -- Pages:126 to 129

Global Environmental Health

Global Environmental Health
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 141
Release: 2009-07-08
Genre: Science
ISBN: 0309141842

The issues surrounding water services are some of the most critical challenges facing not only the United States, but also the global community today. The Roundtable on Environmental Health Sciences, Research, and Medicine of the Institute of Medicine convened a workshop in October 2007, summarized in this volume, to address objectives related to Sustainable Water, Sanitation, and Hygiene Services. One of the objectives of the workshop was to think about the interdependence of environmental health and human health as connected through water. Organizations cannot discuss water without considering the interrelationship of sanitation and hygiene. It is the convergence of these strategies that promotes healthy outcomes for both individuals and the environment. A second objective of the workshop was to consider how planning, management, and interdisciplinary approaches-including technology, social behavioral issues, gender, health, environment, economic, and political aspects-can be integrated to arrive at sustainable solutions. Many organizations and agencies are trying to forge a path toward sustainable practices in water, but the various sectors utilizing and governing water services are not interconnected. More integration and a greater understanding of holistic approaches are needed.

Local Government Network Regional Workshop Meeting Summary

Local Government Network Regional Workshop Meeting Summary
Author: Barry Leonard
Publisher: DIANE Publishing
Total Pages: 74
Release: 1998-06
Genre:
ISBN: 9780788170225

Describes the events of the workshop which included participants from local jurisdictions along transportation corridors for U.S. Dept. of Energy's (DOE) radioactive materials, as well as local government participants representing fire & police departments, hazardous materials teams, & divisions of emergency management. Also included were participants from state governments, tribal & DOE representatives, & planning committee members from the Urban Energy & Transportation Corp. Includes route maps for transporting DOE materials.

Improving the Quality of Cancer Clinical Trials

Improving the Quality of Cancer Clinical Trials
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 136
Release: 2008-05-12
Genre: Medical
ISBN: 0309178258

Scientists and clinicians seek a new paradigm that could improve the efficiency, cost-effectiveness, and overall success rate of cancer clinical trials, while maintaining the highest standards of quality. To explore innovative paradigms for cancer clinical trials and other ways to improve their quality, the National Cancer Policy Forum held a workshop, Improving the Quality of Cancer Clinical Trials, in Washington, DC. The main goals of the workshop were to examine new approaches to clinical trial design and execution that would: (1) better inform decisions and plans of those responsible for developing new cancer therapies (2) more rapidly move new diagnostic tests and treatments toward regulatory approval and use in the clinic (3) be less costly than current trials The resulting workshop summary will serve as input to the deliberations of an Institute of Medicine committee that will develop consensus-based recommendations for moving the field of cancer clinical trials forward.