A computer library of the antimotion sickness drug literature has been established at the Naval Aerospace Medical Institute. A review of this literature is reported here. The over-all effectiveness of the antihistamines was 70.6 per cent; for the belladonnas it was 50.1 per cent, and for the phenothiazines it was 44.9 per cent. The over-all results of British studies indicated a greater effectiveness for the belladonnas than for the antihistamines, the reverse of U.S. studies. The effectiveness of the individual drugs against motion sickness is also reported. The over-all effectiveness of the drugs is compared in sea, air, and experimental motion studies. (Author).