Computational Genomic Analysis Of Transcriptional Regulation In Innate Lymphoid Cell Development
Download Computational Genomic Analysis Of Transcriptional Regulation In Innate Lymphoid Cell Development full books in PDF, epub, and Kindle. Read online free Computational Genomic Analysis Of Transcriptional Regulation In Innate Lymphoid Cell Development ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : Herman Gudjonson |
| Publisher | : |
| Total Pages | : 144 |
| Release | : 2017 |
| Genre | : |
| ISBN | : 9780355519983 |
Innate lymphoid cells (ILCs) are a recently identified subset of the innate immune system found to have transformative roles in integrating innate and adaptive immune responses. In a wide distribution of tissues, ILCs are important sources of cytokines that promote inflammation, host defense against infection, tissue repair, regulation of microbiota, and physiological homeostasis. As a newly appreciated lineage, many aspects of ILC development and differentiation are not well understood. The Bendelac lab recently identified a common ILC precursor (ILCP) in the fetal liver and bone marrow on the basis of expression of PLZF, the NKT master regulator. The ILCP gives rise to all ILC lineages, including ILC1, ILC2, and ILC3, but not LTi or NK. The developmental stages and associated regulatory factors surrounding the emergence and differentiation of the ILCP have yet to be defined. We present three experimental designs that probe transcriptional regulation in ILC precursors. First we use genome-wide expression profiling to describe the role PLZF plays in distinguishing cNK and ILC1 lineages. Next we performed computational clustering of single ILC progenitor expression profiles to establish a hierarchy of ILC development and found: 1) There is a specific developmental progression of transcription factor induction upstream of the ILCP. 2) ILC differentiation occurs after acquisition of PLZF in the ILCP. 3) LTi specification immediately precedes ILC differentiation and is a distinct lineage decision. 4) ILC differentiation occurs through multilineage transcriptional priming. Finally, we compared chromatin accessibility transcriptional profiling in the ILPC to identify the predominant transcriptional regulators affiliated with ILC specification. The precise elaboration of ILC developmental stages and identification of novel ILC developmental regulators will improve our understanding of the functional requirements of ILCs and their roles in immunity.
| Author | : Bruce Alberts |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cytology |
| ISBN | : 9780815332183 |
| Author | : Rémy Bosselut |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2015-08-22 |
| Genre | : Medical |
| ISBN | : 9781493928088 |
This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, T-Cell Development: Methods and Protocols aims to ensure successful results in the further study of this vital field.
| Author | : Yoram Groner |
| Publisher | : Springer |
| Total Pages | : 518 |
| Release | : 2017-03-15 |
| Genre | : Medical |
| ISBN | : 9811032335 |
This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
| Author | : M. A. Epstein |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 467 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642672361 |
The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
| Author | : Isabelle S. Peter |
| Publisher | : Academic Press |
| Total Pages | : 461 |
| Release | : 2015-01-21 |
| Genre | : Science |
| ISBN | : 0124047467 |
Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
| Author | : Petar Djuric |
| Publisher | : Academic Press |
| Total Pages | : 868 |
| Release | : 2018-07-04 |
| Genre | : Computers |
| ISBN | : 0128136782 |
Cooperative and Graph Signal Processing: Principles and Applications presents the fundamentals of signal processing over networks and the latest advances in graph signal processing. A range of key concepts are clearly explained, including learning, adaptation, optimization, control, inference and machine learning. Building on the principles of these areas, the book then shows how they are relevant to understanding distributed communication, networking and sensing and social networks. Finally, the book shows how the principles are applied to a range of applications, such as Big data, Media and video, Smart grids, Internet of Things, Wireless health and Neuroscience. With this book readers will learn the basics of adaptation and learning in networks, the essentials of detection, estimation and filtering, Bayesian inference in networks, optimization and control, machine learning, signal processing on graphs, signal processing for distributed communication, social networks from the perspective of flow of information, and how to apply signal processing methods in distributed settings. Presents the first book on cooperative signal processing and graph signal processing Provides a range of applications and application areas that are thoroughly covered Includes an editor in chief and associate editor from the IEEE Transactions on Signal Processing and Information Processing over Networks who have recruited top contributors for the book
| Author | : Ann Arvin |
| Publisher | : Cambridge University Press |
| Total Pages | : 1325 |
| Release | : 2007-08-16 |
| Genre | : Medical |
| ISBN | : 1139461648 |
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
| Author | : Suzanne Segerstrom |
| Publisher | : Oxford University Press |
| Total Pages | : 523 |
| Release | : 2012-07-19 |
| Genre | : Medical |
| ISBN | : 0195394399 |
This volume collects the state-of-the-art applications of psychological theory to the interactions among the mind, the nervous system, and the immune system, including applications drawn from affective science, developmental psychology, behavioral neuroscience, and clinical psychology.
| Author | : |
| Publisher | : |
| Total Pages | : 657 |
| Release | : 2020 |
| Genre | : Cancer |
| ISBN | : 9789811532672 |
This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
