Computational Chemotaxis Models For Neurodegenerative Disease
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Author | : William E Schiesser |
Publisher | : World Scientific Publishing Company |
Total Pages | : 172 |
Release | : 2017-02-24 |
Genre | : Technology & Engineering |
ISBN | : 9813207477 |
The mathematical model presented in this book, based on partial differential equations (PDEs) describing attractant-repellent chemotaxis, is offered for a quantitative analysis of neurodegenerative disease (ND), e.g., Alzheimer's disease (AD). The model is a representation of basic phenomena (mechanisms) for diffusive transport and biochemical kinetics that provides the spatiotemporal distribution of components which could explain the evolution of ND, and is offered with the intended purpose of providing a small step toward the understanding, and possible treatment of ND.The format and emphasis of the presentation is based on the following elements:In other words, a methodology for numerical PDE modeling is presented that is flexible, open ended and readily implemented on modest computers. If the reader is interested in an alternate model, it might possibly be implemented by: (1) modifying and/or extending the current model (for example, by adding terms to the PDEs or adding additional PDEs), or (2) using the reported routines as a prototype for the model of interest.These suggestions illustrate an important feature of computer-based modeling, that is, the readily available procedure of numerically experimenting with a model. The current model is offered as only a first step toward the resolution of this urgent medical problem.
Author | : W. E. Schiesser |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : 9789813207462 |
Author | : Panagiotis Vlamos |
Publisher | : Springer Nature |
Total Pages | : 1031 |
Release | : 2023-07-25 |
Genre | : Medical |
ISBN | : 3319759221 |
The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of research on neurodegeneration and dispersed publications for specialists that have a narrowed focus on computational methods to study this complicated process. The handbook reviews the central issues and methodological approaches related to the field for which the reader pursues a thorough overview. It also conveys more advanced knowledge, thus serving both as an introductory text and as a starting point for an in-depth study of a specific area, as well as a quick reference source for the expert by reflecting the state of the art and future prospects. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature. The broad scope of this handbook is reflected by five major parts that facilitate an integration of computational concepts, methods and applications in the study of neurodegeneration. Each part is intended to stand on its own, giving an overview of the topic and the most important problems and approaches, which are supported by examples, practical applications, and proposed methodologies. The basic concepts and knowledge, standard procedures and methods are presented, as well as recent advances and new perspectives.
Author | : Sumeet Dua |
Publisher | : World Scientific |
Total Pages | : 467 |
Release | : 2011 |
Genre | : Technology & Engineering |
ISBN | : 9814340294 |
Advances in semi-automated high-throughput image data collection routines, coupled with a decline in storage costs and an increase in high-performance computing solutions have led to an exponential surge in data collected by biomedical scientists and medical practitioners. Interpreting this raw data is a challenging task, and nowhere is this more evident than in the field of opthalmology. The sheer speed at which data on cataracts, diabetic retinopathy, glaucoma and other eye disorders are collected, makes it impossible for the human observer to directly monitor subtle, yet critical details. This book is a novel and well-timed endeavor to present, in an amalgamated format, computational image modeling methods as applied to various extrinsic scientific problems in ophthalmology. It is self-contained and presents a highly comprehensive array of image modeling algorithms and methodologies relevant to ophthalmologic problems. The book is the first of its kind, bringing eye imaging and multi-dimensional hyperspectral imaging and data fusion of the human eye, into focus. The editors are at the top of their fields and bring a strong multidisciplinary synergy to this visionary volume. Their "inverted-pyramid" approach in presenting the content, and focus on core applications, will appeal to students and practitioners in the field.
Author | : Yuen-Cheng Fung |
Publisher | : World Scientific Publishing Company |
Total Pages | : 838 |
Release | : 2016-11-30 |
Genre | : Technology & Engineering |
ISBN | : 9789814713641 |
The second edition provides an update of the recent developments in classical and computational solid mechanics. The structure of the book is also updated to include five new areas: Fundamental Principles of Thermodynamics and Coupled Thermoelastic Constitutive Equations at Large Deformations, Functional Thermodynamics and Thermoviscoelasticity, Thermodynamics with Internal State Variables and Thermo-Elasto-Viscoplasticity, Electro-Thermo-Viscoelasticity/Viscoplasticity, and Meshless Method. These new topics are added as self-contained sections or chapters. Many books in the market do not cover these topics. This invaluable book has been written for engineers and engineering scientists in a style that is readable, precise, concise, and practical. It gives the first priority to the formulation of problems, presenting the classical results as the gold standard, and the numerical approach as a tool for obtaining solutions.
Author | : |
Publisher | : |
Total Pages | : 576 |
Release | : 2005 |
Genre | : Life sciences |
ISBN | : |
Author | : William E Schiesser |
Publisher | : World Scientific |
Total Pages | : 460 |
Release | : 2018-06-27 |
Genre | : Technology & Engineering |
ISBN | : 9813238801 |
The intent of this book is to provide a methodology for the analysis of infectious diseases by computer-based mathematical models. The approach is based on ordinary differential equations (ODEs) that provide time variation of the model dependent variables and partial differential equations (PDEs) that provide time and spatial (spatiotemporal) variations of the model dependent variables.The starting point is a basic ODE SIR (Susceptible Infected Recovered) model that defines the S,I,R populations as a function of time. The ODE SIR model is then extended to PDEs that demonstrate the spatiotemporal evolution of the S,I,R populations. A unique feature of the PDE model is the use of cross diffusion between populations, a nonlinear effect that is readily accommodated numerically. A second feature is the use of radial coordinates to represent the geographical distribution of the model populations.The numerical methods for the computer implementation of ODE/PDE models for infectious diseases are illustrated with documented R routines for particular applications, including models for malaria and the Zika virus. The R routines are available from a download so that the reader can reproduce the reported solutions, then extend the applications through computer experimentation, including the addition of postulated effects and associated equations, and the implementation of alternative models of interest.The ODE/PDE methodology is open ended and facilitates the development of computer-based models which hopefully can elucidate the causes/conditions of infectious disease evolution and suggest methods of control.
Author | : Robert Langer |
Publisher | : World Scientific |
Total Pages | : 495 |
Release | : 2012-12-26 |
Genre | : Technology & Engineering |
ISBN | : 9814405531 |
The field of microfluidics has in the last decade permeated many disciplines, from physics to biology and chemistry, and from bioengineering to medical research. One of the most important applications of lab-on-a-chip devices in medicine and related disciplines is disease diagnostics, which involves steps from biological sample/analyte loading to storage, detection, and analysis. The chapters collected in this book detail recent advances in these processes using microfluidic devices and systems. The reviews of portable devices for diagnostic purposes are likely to evoke interest and raise new research questions in interdisciplinary fields (e.g., efficient MEMS/microfluidic engineering driven by biological and medical applications).The variety of the selected topics (general relevance of microfluidics in medical and bioengineering research, fabrication, advances in on-chip sample detection and analysis, and specific disease models) ensures that each of them can be viewed in the larger context of microfluidic-mediated diagnostics.
Author | : Miguel Antonio Aon |
Publisher | : World Scientific |
Total Pages | : 266 |
Release | : 2002-03-07 |
Genre | : Science |
ISBN | : 9814489514 |
Metabolic and cellular engineering, as presented in this book, is a powerful alliance of two technologies: genetics-molecular biology and fermentation technology. Both are driven by continuous refinement of the basic understanding of metabolism, physiology and cellular biology (growth, division, differentiation), as well as the development of new mathematical modeling techniques. The authors' approach is original in that it integrates several disciplines into a coordinated scheme, i.e. microbial physiology and bioenergetics, thermodynamics and enzyme kinetics, biomathematics and biochemistry, genetics and molecular biology. Thus, it is called a transdisciplinary approach (TDA). The TDA provides the basis for the rational design of microorganisms or cells in a way that has rarely been utilized to its full extent.
Author | : Jancy C. McPhee |
Publisher | : U. S. National Aeronautics & Space Administration |
Total Pages | : 396 |
Release | : 2009 |
Genre | : Biography & Autobiography |
ISBN | : |