Computational Analysis Of G Protein Coupled Receptor Screening Dimerization And Desensitization
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The G Protein-Coupled Receptors Handbook
| Author | : Lakshmi A. Devi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 414 |
| Release | : 2008-03-01 |
| Genre | : Medical |
| ISBN | : 1592599192 |
A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
Receptor-Receptor Interactions
| Author | : Kjell Fuxe |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 577 |
| Release | : 2013-03-13 |
| Genre | : Computers |
| ISBN | : 1468454153 |
Serotonin Receptors in Neurobiology
| Author | : Amitabha Chattopadhyay |
| Publisher | : CRC Press |
| Total Pages | : 230 |
| Release | : 2007-05-17 |
| Genre | : Medical |
| ISBN | : 1420005758 |
A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l
G Protein-Coupled Receptor Signaling
| Author | : Mario Tiberi |
| Publisher | : Humana Press |
| Total Pages | : 406 |
| Release | : 2019-03-01 |
| Genre | : Science |
| ISBN | : 9781493991204 |
This detailed volume assembles comprehensive protocols to assist with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and to enable the development of experimental tools for screening novel GPCR drugs. Sections explore the tweaking of ligands, bioluminescence and FRET approaches, specific GPCR signaling properties, as well as visualization of subcellular compartmentalization. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, G Protein-Coupled Receptor Signaling: Methods and Protocols serves as an ideal reference for life scientists working in a variety of research fields including molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening. Chapter 4 is available open access under a CC BY 4.0 license via link.springer.com.
G-Protein-Coupled Receptor Dimers
| Author | : Katharine Herrick-Davis |
| Publisher | : Humana Press |
| Total Pages | : 501 |
| Release | : 2017-09-12 |
| Genre | : Medical |
| ISBN | : 9783319601724 |
G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.
Membrane Proteins – Engineering, Purification and Crystallization
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 663 |
| Release | : 2015-04-30 |
| Genre | : Science |
| ISBN | : 0128021934 |
Membrane Proteins – Engineering, Purification and Crystallization, a volume of Methods In Enzymology, encompasses chapters from the leading experts in the area of membrane protein biology. The chapters provide a brief overview of the topics covered and also outline step-by-step protocol for the interested audience. Illustrations and case example images are included wherever appropriate to help the readers understand the schematics and general experimental outlines. Volume of Methods In Enzymology Contains a collection of a diverse array of topics in the area of membrane protein biology ranging from recombinant expression, isolation, functional characterization, biophysical studies and crystallization
Molecular Biology of The Cell
| Author | : Bruce Alberts |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cytology |
| ISBN | : 9780815332183 |
