Comprehensive Analysis Of Parasite Biology
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| Author | : Sylke Müller |
| Publisher | : John Wiley & Sons |
| Total Pages | : 574 |
| Release | : 2016-10-10 |
| Genre | : Medical |
| ISBN | : 3527339043 |
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 312 |
| Release | : 1991-02-01 |
| Genre | : Medical |
| ISBN | : 9780309045278 |
Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
| Author | : P.K. Bandyopadhyay |
| Publisher | : Springer Nature |
| Total Pages | : 325 |
| Release | : 2022-01-07 |
| Genre | : Medical |
| ISBN | : 9811643849 |
This book comprehensively reviews various vector-borne diseases and their control methods. It discusses morphology, life history, and pathogenicity of protozoan and helminth parasites. Further, it analyzes host-parasite interactions and their adaptation within the host system for understanding parasitic infections. The book discusses the complex life cycle, biochemical adaptations, and molecular biology of the parasites. It investigates the immunological response to different infectious agents and explores new targets for combined therapeutic approaches. It also summarizes the evolution of parasitism and the ecology of parasites of the different phylum. Lastly, it provides information on vector biology emphasizing the role of basic vector research in developing future disease control methods and improving upon the existing approaches.
| Author | : Abhay Prakash Mishra |
| Publisher | : John Wiley & Sons |
| Total Pages | : 436 |
| Release | : 2023-07-18 |
| Genre | : Medical |
| ISBN | : 1119878047 |
Parasitic Infections Understand and defeat a scourge of public health with this cutting-edge guide Parasitic diseases are considered as an important public health problem due to the high morbidity and mortality rates, particularly in countries where climate and level of economic development create serious challenges to the creation of public health infrastructure, thus can make parasitic infections both graver and more difficult to contain. As we come to understand the global ramifications of public health, there has never been a more crucial time to understand these infections and the processes by which they can be managed and defeated. Parasitic Infections is a comprehensive overview of parasitic immunopathology, including the fundamentals of parasite biology, mechanisms and processes of infection, and the key steps of drug discovery and treatment. In addition to detailed coverage of the most commonly encountered infectious parasites, analysis of the immune system provides material pertinent to any possible parasitic infection. The result is an essential contribution to public health research. Parasitic Infections readers will also find: A careful balance of parasite immunopathology and pharmaceutical analysis Detailed discussion of parasites such as protozoans, helminths, and ectoparasites Case studies and in-depth analyses written by authors around the world on the basis of first hand investigation Parasitic Infections is a must-read for researchers or professionals in immunology, biology, medicinal chemistry, drug development or pharmaceutical research, and all related fields.
| Author | : Michael T. Rogan |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 381 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642603459 |
Parasitic diseases still affect millions of people every year, especially in the tropics, causing considerable morbidity or death. Such infections within livestock are probably an even bigger problem, leading to poorer productivity, condemna tion of infected meat and considerable economic loss. Para sitological research has, however, helped the situation in some cases and the development of novel drugs, vaccines and diagnostics has improved our chances of controlling these diseases. Research into parasitic infections is, therefore, often goal orientated. However, the study of parasites and host/parasite relationships still remains one of the most exciting and in teresting aspects of biology. Scientists, from undergraduate students to research professors, frequently ponder over how endoparasitic organisms can survive within the most alien of environments - inside another organism. The nutritional, reproductive and survival strategies which have evolved within each group of parasites have allowed the development of highly specific host-parasite relationships and allow the successful transmission of the parasite from one host to an other. A considerable amount of research is therefore direc ted at improving our understanding of various aspects of parasite biology.
| Author | : Wanderley De Souza |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 236 |
| Release | : 2019-12-18 |
| Genre | : Medical |
| ISBN | : 1839682035 |
Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective stages are able to penetrate into a mammalian host cell, where they multiply several times and thus amplify the infection; and (3) evasion from the immune system, using several mechanisms. This book, with 13 chapters, has been organized in four major sections: 1. "Basic Biology," 2. "Biochemistry and Molecular Biology," 3. "Parasite"Host Cell Interaction," and 4 "Chemotherapy." The chapters include basic biological information on the protozoan lifecycle, including new information on parasite genomics and proteomics. In addition, they analyze the interaction with host cells as well the immune response and evasion, ending with information on experimental chemotherapy against Chagas disease.
| Author | : Sylke Müller |
| Publisher | : John Wiley & Sons |
| Total Pages | : 576 |
| Release | : 2016-07-19 |
| Genre | : Medical |
| ISBN | : 3527694099 |
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
| Author | : Richard Lucius |
| Publisher | : John Wiley & Sons |
| Total Pages | : 466 |
| Release | : 2017-04-10 |
| Genre | : Medical |
| ISBN | : 3527328483 |
This heavily illustrated text teaches parasitology from a biological perspective. It combines classical descriptive biology of parasites with modern cell and molecular biology approaches, and also addresses parasite evolution and ecology. Parasites found in mammals, non-mammalian vertebrates, and invertebrates are systematically treated, incorporating the latest knowledge about their cell and molecular biology. In doing so, it greatly extends classical parasitology textbooks and prepares the reader for a career in basic and applied parasitology.
| Author | : Edwin Michael |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 236 |
| Release | : 2010-12-31 |
| Genre | : Medical |
| ISBN | : 1441960643 |
It is clear that many fascinating problems still remain to be addressed in parasite transmission modelling, from better understanding of transmission processes and natural history of infection to investigating the impact of ecological and spatial scales, climate change, host immunity and social behaviour, parasite-host evolutionary dynamics and parasite community ecology on parasite transmission. This book captures some of the advances made in recent years and provides indications of ways forward for addressing these questions by shedding light on developments in conceptual frameworks and modelling tools as well as the emergence of new data forms for aiding model construction, testing and analysis. Another important advance has been the parallel development of robust computationally-intensive statistical methods to allow model testing and parameterization by aiding the fitting of models to complex data. This is an exciting area of work, which we believe will broaden the scope of mathematical modelling in investigating parasite transmission processes. In particular, we expect this advance will now allow modellers to begin the successful development and analysis of mechanistically-rich models of parasite transmission that will facilitate better integration of the variety of mechanisms increasingly recognized as important in simultaneously affecting transmission, including abiotic processes, trophic and evolutionary interactions, movement in space, and behaviour and even physiology of the individual. We foresee a continuing bright future for using mathematical modelling to clarify parasite transmission dynamics and address problems related to effective parasite control. Ultimately, through this improved application of models to research and management, we expect that parasite control would be an achievable goal bringing benefits to a vast number of our fellow human beings.
| Author | : Christian Tschudi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 339 |
| Release | : 2013-03-14 |
| Genre | : Medical |
| ISBN | : 1475746229 |
Biology of Parasitism is based on the Biology of Parasitism Course at the Marine Biological Laboratory in Woods Hole, Massachusetts. Having just celebrated its 20th offering, this Course has distinguished itself as the premier, world-renowned training ground for future generations of parasitologists. The primary goal of the Course is to attract and introduce the very best and most promising young researchers to the many unresolved problems in parasitology and prepare them for their future as independent investigators in the field. The rigorous program combines state-of-the-art laboratory research with a program of visiting lecturers who bring together the most current research in the field. Since at this time there are no academic institutions that have enough depth in parasitology research or teaching faculty to provide up-to-date and state-of-the-art training, the Course has become, and will remain, a global resource for providing intensive education in modern parasitology. Biology of Parasitism is intended to present a snapshot of the content and spirit of the Biology of Parasitism Course. By presenting a series of chapters that reflect the formal lectures that students receive on a daily basis, as well as the approaches used during the laboratory section of the Course, the editors hope to share some of the science that occurs there. One part of the book presents the experimental component of the Course, in particular the subject matter of the four two-week sessions covering Immunology, Biochemistry, Cell Biology and Molecular Biology of protozoan and helminth parasites. As in the Course, the experimental part is complemented by a number of review-like chapters solicited from the large number of speakers who lecture during the Course.
