Community Series In The Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease Volume Ii
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| Author | : Luc Van Kaer |
| Publisher | : Frontiers Media SA |
| Total Pages | : 177 |
| Release | : 2024-09-26 |
| Genre | : Medical |
| ISBN | : 2832554830 |
This is the second volume in the series, the Role of CD1- and MR1-restricted T cells in Immunity and Disease. Please see volume I here. CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen-presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b, and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which include Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory, and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α or α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells.
| Author | : Kazuya Iwabuchi |
| Publisher | : Frontiers Media SA |
| Total Pages | : 429 |
| Release | : 2019-10-18 |
| Genre | : |
| ISBN | : 2889631222 |
CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
| Author | : S.M. Mansour Haeryfar |
| Publisher | : Frontiers Media SA |
| Total Pages | : 191 |
| Release | : 2016-01-21 |
| Genre | : Cytology |
| ISBN | : 2889197506 |
Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.
| Author | : Harris G. Fienberg |
| Publisher | : Springer |
| Total Pages | : 224 |
| Release | : 2014-04-22 |
| Genre | : Medical |
| ISBN | : 364254827X |
This volume highlights the most interesting biomedical and clinical applications of high-dimensional flow and mass cytometry. It reviews current practical approaches used to perform high-dimensional experiments and addresses key bioinformatic techniques for the analysis of data sets involving dozens of parameters in millions of single cells. Topics include single cell cancer biology; studies of the human immunome; exploration of immunological cell types such as CD8+ T cells; decipherment of signaling processes of cancer; mass-tag cellular barcoding; analysis of protein interactions by proximity ligation assays; Cytobank, a platform for the analysis of cytometry data; computational analysis of high-dimensional flow cytometric data; computational deconvolution approaches for the description of intracellular signaling dynamics and hyperspectral cytometry. All 10 chapters of this book have been written by respected experts in their fields. It is an invaluable reference book for both basic and clinical researchers.
| Author | : Steven A. Frank |
| Publisher | : Princeton University Press |
| Total Pages | : 364 |
| Release | : 2002-07-21 |
| Genre | : Medical |
| ISBN | : 9780691095950 |
| Author | : E. Edmund Kim |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 322 |
| Release | : 2001 |
| Genre | : Medical |
| ISBN | : 9780387950280 |
Cancer cells dedifferentiate with repect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also describes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.
| Author | : Martin Flajnik |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 3597 |
| Release | : 2022-07-19 |
| Genre | : Medical |
| ISBN | : 1975142527 |
Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
| Author | : M. Eric Gershwin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 482 |
| Release | : 2013-11-19 |
| Genre | : Medical |
| ISBN | : 331902096X |
Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.
| Author | : Michael R Shurin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 452 |
| Release | : 2007-09-23 |
| Genre | : Medical |
| ISBN | : 0387720057 |
This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who were eager to share some of the academic and clinical enthusiasm that defines the IMD meetings. The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the world’s best immunologists and clinicians to Moscow.
| Author | : Sebastian Boegel |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2020-03-03 |
| Genre | : Medical |
| ISBN | : 9781071603260 |
This volume focuses on a variety of in silico protocols of the latest bioinformatics tools and computational pipelines developed for neo-antigen identification and immune cell analysis from high-throughput sequencing data for cancer immunotherapy. The chapters in this book cover topics that discuss the two emerging concepts in recognition of tumor cells using endogenous T cells: cancer vaccines against neo-antigens presented on HLA class I and II alleles, and checkpoint inhibitors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Bioinformatics for Cancer Immunotherapy: Methods and Protocols is a valuable research tool for any scientist and researcher interested in learning more about this exciting and developing field.
