In recent years, the scientific community’s interest towards efficient energy conversion systems has significantly increased. One of the reasons is certainly related to the change in the temperature of the planet, which appears to have increased by 0.76 °C with respect to pre-industrial levels, according to the Intergovernmental Panel on Climate Change (IPCC), and this trend has not yet been stopped. The European Union considers it vital to prevent global warming from exceeding 2 °C with respect to pre-industrial levels, since this phenomenon has been proven to result in irreversible and potentially catastrophic changes. These climate changes are mainly caused by the emissions of greenhouse gasses related to human activities, and can be drastically reduced by employing energy systems, for both heating and cooling of buildings and for power production, characterized by high efficiency levels and/or based on renewable energy sources. This Special Issue, published in the journal Energies, includes 12 contributions from across the world, including a wide range of applications, such as HT-PEMFC, district heating systems, a thermoelectric generator for industrial waste, artificial ground freezing, nanofluids, and others.