Collaborative Computational Technologies For Biomedical Research
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| Author | : Sean Ekins |
| Publisher | : John Wiley & Sons |
| Total Pages | : 462 |
| Release | : 2011-08-04 |
| Genre | : Science |
| ISBN | : 1118026020 |
Methods, Processes, and Tools for Collaboration "The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types." Bryn Williams-Jones, Associate Research Fellow, Pfizer The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new drugs, however there is currently little guidance for managing information and resources across collaborations. Featuring contributions from the leading experts in a range of industries, Collaborative Computational Technologies for Biomedical Research provides information that will help organizations make critical decisions about managing partnerships, including: Serving as a user manual for collaborations Tackling real problems from both human collaborative and data and informatics perspectives Providing case histories of biomedical collaborations and technology-specific chapters that balance technological depth with accessibility for the non-specialist reader A must-read for anyone working in the pharmaceuticals industry or academia, this book marks a major step towards widespread collaboration facilitated by computational technologies.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 121 |
| Release | : 2009-02-24 |
| Genre | : Computers |
| ISBN | : 0309155843 |
Despite a strong commitment to delivering quality health care, persistent problems involving medical errors and ineffective treatment continue to plague the industry. Many of these problems are the consequence of poor information and technology (IT) capabilities, and most importantly, the lack cognitive IT support. Clinicians spend a great deal of time sifting through large amounts of raw data, when, ideally, IT systems would place raw data into context with current medical knowledge to provide clinicians with computer models that depict the health status of the patient. Computational Technology for Effective Health Care advocates re-balancing the portfolio of investments in health care IT to place a greater emphasis on providing cognitive support for health care providers, patients, and family caregivers; observing proven principles for success in designing and implementing IT; and accelerating research related to health care in the computer and social sciences and in health/biomedical informatics. Health care professionals, patient safety advocates, as well as IT specialists and engineers, will find this book a useful tool in preparation for crossing the health care IT chasm.
| Author | : Joseph Morabito |
| Publisher | : John Wiley & Sons |
| Total Pages | : 450 |
| Release | : 2017-08-14 |
| Genre | : Technology & Engineering |
| ISBN | : 1118905849 |
A pedagogical approach to the principles and architecture of knowledge management in organizations This textbook is based on a graduate course taught at Stevens Institute of Technology. It focuses on the design and management of today's complex K organizations. A K organization is any company that generates and applies knowledge. The text takes existing ideas from organizational design and knowledge management to enhance and elevate each through harmonization with concepts from other disciplines. The authors—noted experts in the field—concentrate on both micro- and macro design and their interrelationships at individual, group, work, and organizational levels. A key feature of the textbook is an incisive discussion of the cultural, practice, and social aspects of knowledge management. The text explores the processes, tools, and infrastructures by which an organization can continuously improve, maintain, and exploit all elements of its knowledge base that are most relevant to achieve its strategic goals. The book seamlessly intertwines the disciplines of organizational design and knowledge management and offers extensive discussions, illustrative examples, student exercises, and visualizations. The following major topics are addressed: Knowledge management, intellectual capital, and knowledge systems Organizational design, behavior, and architecture Organizational strategy, change, and development Leadership and innovation Organizational culture and learning Social networking, communications, and collaboration Strategic human resources; e.g., hiring K workers and performance reviews Knowledge science, thinking, and creativity Philosophy of knowledge and information Information, knowledge, social, strategy, and contract continuums Information management and intelligent systems; e.g., business intelligence, big data, and cognitive systems Designing Knowledge Organizations takes an interdisciplinary and original approach to assess and synthesize the disciplines of knowledge management and organizational design, drawing upon conceptual underpinnings and practical experiences in these and related areas.
| Author | : Rathnam Chaguturu |
| Publisher | : John Wiley & Sons |
| Total Pages | : 768 |
| Release | : 2014-04-14 |
| Genre | : Medical |
| ISBN | : 0470917377 |
Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing patent expiration. Dr. Rathnam Chaguturu presents a case for collaboration between the pharmaceutical industry and academia that could reverse the industry's decline. Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships provides insight into the potential synergy of basing R&D in academia while leaving drug companies to turn hits into marketable products. As Founder and CEO of iDDPartners, focused on pharmaceutical innovation, Founding president of the International Chemical Biology Society, and Senior Director-Discovery Sciences, SRI International, Dr. Chaguturu has assembled a panel of experts from around the world to weigh in on issues that affect the two driving forces in medical advancement. Gain global perspectives on the benefits and potential issues surrounding collaborative innovation Discover how industries can come together to prevent another "Pharma Cliff" Learn how nonprofits are becoming the driving force behind innovation Read case studies of specific academia-pharma partnerships for real-life examples of successful collaboration Explore government initiatives that help foster cooperation between industry and academia Dr. Chaguturu’s thirty-five years of experience in academia and industry, managing new lead discovery projects and forging collaborative partnerships with academia, disease foundations, nonprofits, and government agencies lend him an informative perspective into the issues facing pharmaceutical progress. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships, he and his expert team provide insight into the various nuances of the debate.
| Author | : Sean Ekins |
| Publisher | : John Wiley & Sons |
| Total Pages | : 450 |
| Release | : 2018-02-13 |
| Genre | : Science |
| ISBN | : 111928256X |
Dieses Buch ist ein wichtiges Referenzwerk für Toxikologen in vielen Bereichen und bietet eine umfassende Analyse molekular Modellansätze und Strategien der Risikobewertung von pharmazeutischen und Umweltchemikalien. - Zeigt, was mit rechnergestützter Toxikologie aktuell erreicht werden kann, und wirft einen Blick auf zukünftige Entwicklungen. - Gibt Antworten zu Themen wie Datenquellen, Datenpflege, Behandlung, Modellierung und Interpretation kritischer Endpunkte im Hinblick auf Gefahrenbewertungen im 21. Jahrhundert. - Bündelt herausragende Konzepte und das Wissen führender Autoren in einem einzigartigen Referenzwerk. - Untersucht detailliert QSAR-Modelle, Eigenschaften physiochemischer Arzneistoffe, strukturbasiertes Drug Targeting, die Bewertung chemischer Mischungen und Umweltmodelle. - Behandelt zusätzlich die Sicherheitsbewertung von Verbraucherprodukten und den Bereich chemische Abwehr und bietet Kapitel zu Open-Source-Toxikologie und Big Data.
| Author | : Pietro Michelucci |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1051 |
| Release | : 2013-12-04 |
| Genre | : Computers |
| ISBN | : 1461488060 |
This volume addresses the emerging area of human computation, The chapters, written by leading international researchers, explore existing and future opportunities to combine the respective strengths of both humans and machines in order to create powerful problem-solving capabilities. The book bridges scientific communities, capturing and integrating the unique perspective and achievements of each. It coalesces contributions from industry and across related disciplines in order to motivate, define, and anticipate the future of this exciting new frontier in science and cultural evolution. Readers can expect to find valuable contributions covering Foundations; Application Domains; Techniques and Modalities; Infrastructure and Architecture; Algorithms; Participation; Analysis; Policy and Security and the Impact of Human Computation. Researchers and professionals will find the Handbook of Human Computation a valuable reference tool. The breadth of content also provides a thorough foundation for students of the field.
| Author | : Cerys Willoughby |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 375 |
| Release | : 2019-07-15 |
| Genre | : Computers |
| ISBN | : 1788018443 |
For most of the history of scientific endeavour, science has been recorded on paper. In this digital era, however, there is increasing pressure to abandon paper in favour of digital tools. Despite the benefits, there are barriers to the adoption of such tools, not least their usability. As the relentless development of technology changes the way we work, we need to ensure that the design of technology not only overcomes these barriers, but facilitates us as scientists and supports better practice within science. This book examines the importance of record-keeping in science, current record-keeping practices, and the role of technology for enabling the effective capture, reuse, sharing, and preservation of scientific data. Covering the essential areas of electronic laboratory notebooks (ELNs) and digital tools for recording scientific data, including an overview of the current data management technology available and the benefits and pitfalls of using these technologies, this book is a useful tool for those interested in implementing digital data solutions within their research groups or departments. This book also provides insight into important factors to consider in the design of digital tools such as ELNs for those interested in producing their own tools. Finally, it looks at the role of current technology and then considers how that technology might develop in the future to better support scientists in their work, and in capturing and sharing the scientific record.
| Author | : José Miguel Vela |
| Publisher | : John Wiley & Sons |
| Total Pages | : 600 |
| Release | : 2014-07-31 |
| Genre | : Medical |
| ISBN | : 3527679367 |
This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.
| Author | : Svetla Baykoucheva |
| Publisher | : Chandos Publishing |
| Total Pages | : 163 |
| Release | : 2015-07-14 |
| Genre | : Business & Economics |
| ISBN | : 0081002378 |
Innovative technologies are changing the way research is performed, preserved, and communicated. Managing Scientific Information and Research Data explores how these technologies are used and provides detailed analysis of the approaches and tools developed to manage scientific information and data. Following an introduction, the book is then divided into 15 chapters discussing the changes in scientific communication; new models of publishing and peer review; ethics in scientific communication; preservation of data; discovery tools; discipline-specific practices of researchers for gathering and using scientific information; academic social networks; bibliographic management tools; information literacy and the information needs of students and researchers; the involvement of academic libraries in eScience and the new opportunities it presents to librarians; and interviews with experts in scientific information and publishing. - Promotes innovative technologies for creating, sharing and managing scientific content - Presents new models of scientific publishing, peer review, and dissemination of information - Serves as a practical guide for researchers, students, and librarians on how to discover, filter, and manage scientific information - Advocates for the adoption of unique author identifiers such as ORCID and ResearcherID - Looks into new tools that make scientific information easy to discover and manage - Shows what eScience is and why it is becoming a priority for academic libraries - Demonstrates how Electronic Laboratory Notebooks can be used to record, store, share, and manage research data - Shows how social media and the new area of Altmetrics increase researchers' visibility and measure attention to their research - Directs to sources for datasets - Provides directions on choosing and using bibliographic management tools - Critically examines the metrics used to evaluate research impact - Aids strategic thinking and informs decision making
| Author | : F. Carminati |
| Publisher | : IOS Press |
| Total Pages | : 296 |
| Release | : 2016-05-31 |
| Genre | : Computers |
| ISBN | : 1614996431 |
The distributed computing infrastructure known as ‘the Grid’ has undoubtedly been one of the most successful science-oriented large- scale IT projects of the past 20 years. It is now a fully operational international entity, encompassing several hundred computing sites on all continents and giving access to hundreds of thousands of CPU (central processing unit) cores and hundreds of petabytes of storage, all connected by robust national and international scientific networks. It has evolved to become the main computational platform many scientific communities. This book presents lectures from the Enrico Fermi International School of Physics summer school Grid and Cloud computing: Concepts and Practical Applications, held in Varenna, Italy, in July 2014. The school aimed to cover the conceptual and practical aspects of both the Grid and Cloud computing. The proceedings included here are divided into eight chapters, with chapters 1, 2, 3 and 8 covering general applications of Grid and Cloud computing in various scientific fields, while chapters 4, 5, 6 and 7 discuss specific technical areas of Grid and Cloud structures. The book will be of interest to all those whose work involves the use of the Grid or Cloud computing.
