The Road to Discovery

The Road to Discovery
Author: Jan Anthony Witkowski
Publisher:
Total Pages: 0
Release: 2016
Genre: Biography & Autobiography
ISBN: 9781621821083

The Road to Discovery: A Short History of Cold Spring Harbor Laboratory was published in 2015 to mark the 125th anniversary of Cold Spring Harbor Laboratory. At Cold Spring Harbor, in a bucolic setting on the north shore of New York's Long Island, two interdependent research centers in biology were founded as Charles Darwin's insights into heredity and evolution shook the world of science. Fifty years later, those centers would emerge as a single institution that would cradle another revolution, the new science of molecular biology, and advance to world renown in research and professional education. It is a remarkable story, with a path of progress that was neither simple nor assured. The Road to Discovery traces half a century of changes in name, leadership, governance, and financial fortune. And scientific missteps, most notoriously in eugenics, were triumphed by innovative work in genetics, human metabolism, and cancer. From the 1940s through the 1960s, the Laboratory was home to fundamental discoveries about the nature of genetic material and a cauldron of critical assessment of ideas about genes by sharp-tongued summer visitors. James D. Watson, a junior member of that group, would go on to deduce the structure of DNA with Francis Crick in 1953 and help create the new field of molecular genetics before returning to Cold Spring Harbor as Director 15 years later. As the book shows, his "Bold Plan" would inspire, cajole, and goad into existence an era of expansion, new research directions, and initiatives in conferences, courses, publishing, and education that redefined the scope of the Laboratory. Under Bruce Stillman's leadership, that scope has grown still more, making the Laboratory unique among research institutions worldwide--envied, imitated, but not reproduced. The book's author is the science historian Jan Witkowski. His knowledge of the subject is wide and his affection for it deep. He brings to his task insights that only a decades-long career as a staff member can provide. For over a century, the Laboratory has been influenced by exceptional personalities, outstanding achievements, and dramatic events. The Road to Discovery captures that history in a lively narrative illuminated by vignettes on the importance of individual scientists and their discoveries. Abundantly documented with material from the Laboratory's archives, it is an accessible book that will appeal to anyone interested in the development of biomedical science and biotechnology through the 20th century to the present day.

Cold Spring Harbor

Cold Spring Harbor
Author: Richard Yates
Publisher: Random House
Total Pages: 192
Release: 2010-12-23
Genre: Fiction
ISBN: 1407015168

Evan Shepard is a young man with a chequered past when he first meets the Drakes, after his car breaks down outside their house. Behind him, he has a troubled adolescence, a failed marriage and a little daughter, but his meeting with the quiet and beautiful Rachel heralds a new start. However, after their swift marriage, things don't work out quite as planned and the stresses of living with Rachel's family, in their shared house in Cold Spring Harbor, begin to take their toll on the new couple.

Lab Ref

Lab Ref
Author: Jane Roskams
Publisher: CSHL Press
Total Pages: 259
Release: 2002
Genre: Biochemistry
ISBN: 0879698152

"The first Lab Ref volume compiled recipes and reference data drawn from a selection of our manuals and was intended to save time and spare frustration." ... "In the same spirit, Lab Ref 2 again assembles in one place a new selection of reference information that should maximize the volume's value in a crowded laboratory environment."--Note.

Experimental Heart

Experimental Heart
Author: Jennifer L. Rohn
Publisher:
Total Pages: 382
Release: 2009
Genre: Fiction
ISBN:

"During his many long nights in the lab, scientist Andy O'Hara has plenty of time to wonder about the mysterious and beautiful Gina, first glimpsed in a lit window across the courtyard. He does not realize she is consumed by her vaccine research, concerned about her biotech company's financial problems, and about to become the prime target of animal rights activists. She is also distracted by a charming pharmaceutical mogul who offers funding for her work and a glamorous escape from her past mistakes." "When Andy finally meets Gina, his monotonous life starts to unravel. Soon he becomes embroiled in an increasingly complex web of deception as he scrambles to discover his rival's true intentions. When Gina abruptly disappears, Andy sets off to find her. But is it too late? Is there a more sinister reason behind Gina's involvement with the company? Is Gina's vaccine all it appears to be? And is Andy ready to acknowledge that there is more to life than work?"--BOOK JACKET.

Phage Display

Phage Display
Author: Carlos F. Barbas
Publisher: CSHL Press
Total Pages: 724
Release: 2001
Genre: Science
ISBN: 0879697407

Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.

Methods in Yeast Genetics

Methods in Yeast Genetics
Author: David C. Amberg
Publisher: CSHL Press
Total Pages: 250
Release: 2005
Genre: Genetics
ISBN: 0879697288

"Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.

Statistics at the Bench

Statistics at the Bench
Author: Martina Bremer
Publisher:
Total Pages: 188
Release: 2010
Genre: Mathematics
ISBN:

This handbook is a convenient bench companion for biologists, designed as a handy reference guide for elementary and intermediate statistical analyses. Statistical methods most frequently used in publications and reports, as well as guidelines for the interpretation of results, are explained using simple examples with complete instructions for Excel.

Telomeres

Telomeres
Author: Titia De Lange
Publisher:
Total Pages: 598
Release: 2006
Genre: Medical
ISBN:

An up-to-date survey of the current exciting state of telomere biology. Telomeres – specialized structures found at the ends of chromosomes – are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Houses for Science

Houses for Science
Author: Elizabeth L. Watson
Publisher: CSHL Press
Total Pages: 351
Release: 1991-01-01
Genre: Science
ISBN: 0879694033

Houses for Science traces the unique architectural and scientific evolution of Cold Spring Harbor Laboratory from whaling village, to "summer camp" for biologists, to world-renowned research and educational institution. Situated on Long Island's fabled North Shore, Cold Spring Harbor Laboratory has a one-hundred-year heritage of superlative basic research in genetics and an architectural patrimony that spans nearly two centuries. In Houses for Science architectural historian Elizabeth Watson skillfully integrates the fascinating story of the construction and preservation of this village of science with a chronological account of the history of the Laboratory and the fundamental discoveries made here. Augmenting this account are essays by Nobel laureate James D. Watson on the key advances made in genetics research during the Laboratory's first one hundred years.