Clinical Xenotransplantation
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| Author | : David K. C. Cooper |
| Publisher | : Springer Nature |
| Total Pages | : 313 |
| Release | : 2020-09-08 |
| Genre | : Medical |
| ISBN | : 3030491277 |
This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 134 |
| Release | : 1996-07-12 |
| Genre | : Medical |
| ISBN | : 0309175267 |
Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical trials. The volume focuses on the science base of xenotransplantation, public health risks of infectious disease transmission, and ethical and public policy issues, including the views of patients and their families.
| Author | : David K.C. Cooper |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 877 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642605729 |
This is a time ofexcitement and progress in the field ofxenotransplantation. The work described in this book traces the development of the science of cross-spe cies transplantation, summarizes the current state ofour knowledge, and focuses on approaches directed toward future clinical application. The important question is not whether xenotransplantation will succeed, but rather how and under what circumstances xenografts will provide predictable enough results to warrant clinical application. The fact that the best results to date in clinical xenografting were achieved over three decades ago should not be a matter of discouragement, but rather a stimulus to apply new approaches to this area of work. The shortage of human organs for transplantation is cited frequently as the driving force behind the increased interest in xenotransplantation. This shortage is an undeniable fact, but there are additional potential advantages of xenotrans plantation, such as the ability to schedule replacement surgery on an elective basis and the modification of animals, organs, and tissues to improve acceptabil ity in the human host. The advances in the basic science ofxenotransplantation outlined in this book give hope that the immunologic barriers to xenotransplantation will be overcome and that transplanted organs and tissues will succeed consistently in humans. However, if our experience with human allografts provides an analogy, we may anticipate that clinical progress in xenografts will be plagued by failures and rewarded by successes, often without a complete understanding of the mechan isms involved.
| Author | : David K. C. Cooper |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 299 |
| Release | : 2000 |
| Genre | : Health & Fitness |
| ISBN | : 0195128338 |
With profound implications for human health and longevity, "Xeno" is a fascinating exploration of the medical, ethical, legal, and social issues surrounding the future of organ transplantation. 17 halftones. Line illustrations.
| Author | : Jeffrey L. Platt |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 269 |
| Release | : 2002-05-07 |
| Genre | : Medical |
| ISBN | : 1592591663 |
Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.
| Author | : David K. C. Cooper |
| Publisher | : |
| Total Pages | : 458 |
| Release | : |
| Genre | : Medical |
| ISBN | : 9781536139464 |
There is a critical and continuing shortage of organs and cells from deceased human donors for the purposes of transplantation into patients with terminal organ failure. The use of organs and cells from pigs - i.e., cross-species transplantation, or xenotransplantation - could resolve this problem. Recollections of Pioneers in Xenotransplantation Research is a collection of reminiscences by surgeons and scientists who, over the past 50 years, have made major contributions to research into achieving successful transplantation of pig organs and cells into primates. It records the personal work of 22 researchers from North America, Asia, Europe, and Australasia who developed this field, which will have an immense impact on the future medical care of patients with such diverse conditions as heart and kidney failure, diabetes, corneal blindness, and Parkinson's disease.A pig organ transplanted into a human or nonhuman primate is rejected within minutes. To overcome this immunological barrier, pigs have been genetically-engineered to protect their tissues from the primate immune response. Today, life-supporting organs from pigs with up to six genetic modifications have functioned for more than a year in nonhuman primates, and the blood sugar of diabetic monkeys has been controlled for more than two years by the transplantation of insulin-producing pancreatic islet cells from pigs. Clinical trials of pig islet and corneal transplantation have already been undertaken, and trials of organ transplants are currently being planned.The pioneering researchers who contributed to the early development of this field highlight their own roles, and record their personal recollections of the other scientists and surgeons with whom they collaborated. They do not confine themselves to the scientific progress they made, but comment on the roles of industry and academia in moving the field forward.Recollections of Pioneers in Xenotransplantation Research will be of interest to physicians, scientists, and the lay person with an interest in transplantation or in the care of patients with life-threatening diseases, but also to those interested to understand the potential of genetic-engineering in science and medicine.The book provides a historical record of the research that has contributed to an advance in medicine that has been called "the next great medical revolution." Within a few years, this new form of therapy is likely to impact every family in the developed world.
| Author | : Sara Fovargue |
| Publisher | : Cambridge University Press |
| Total Pages | : 307 |
| Release | : 2011-11-17 |
| Genre | : Law |
| ISBN | : 1139503987 |
Some developing biotechnologies challenge accepted legal and ethical norms because of the risks they pose. Xenotransplantation (cross-species transplantation) may prolong life but may also harm the xeno-recipient and the public due to its potential to transmit infectious diseases. These trans-boundary diseases emphasise the global nature of advances in health care and highlight the difficulties of identifying, monitoring and regulating such risks and thereby protecting individual and public health. Xenotransplantation raises questions about how uncertainty and risk are understood and accepted, and exposes tensions between private benefit and public health. Where public health is at risk, a precautionary approach informed by the harm principle supports prioritising the latter, but the issues raised by genetically engineered solid organ xenotransplants have not, as yet, been sufficiently discussed. This must occur prior to their clinical introduction because of the necessary changes to accepted norms which are needed to appropriately safeguard individual and public health.
| Author | : David K. C. Cooper |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2018 |
| Genre | : MEDICAL |
| ISBN | : 9781536139457 |
There is a critical and continuing shortage of organs and cells from deceased human donors for the purposes of transplantation into patients with terminal organ failure. The use of organs and cells from pigs i.e., cross-species transplantation, or xenotransplantation could resolve this problem. Recollections of Pioneers in Xenotransplantation Research is a collection of reminiscences by surgeons and scientists who, over the past 50 years, have made major contributions to research into achieving successful transplantation of pig organs and cells into primates. It records the personal work of 22 researchers from North America, Asia, Europe, and Australasia who developed this field, which will have an immense impact on the future medical care of patients with such diverse conditions as heart and kidney failure, diabetes, corneal blindness, and Parkinsons disease. A pig organ transplanted into a human or nonhuman primate is rejected within minutes. To overcome this immunological barrier, pigs have been genetically-engineered to protect their tissues from the primate immune response. Today, life-supporting organs from pigs with up to six genetic modifications have functioned for more than a year in nonhuman primates, and the blood sugar of diabetic monkeys has been controlled for more than two years by the transplantation of insulin-producing pancreatic islet cells from pigs. Clinical trials of pig islet and corneal transplantation have already been undertaken, and trials of organ transplants are currently being planned. The pioneering researchers who contributed to the early development of this field highlight their own roles, and record their personal recollections of the other scientists and surgeons with whom they collaborated. They do not confine themselves to the scientific progress they made, but comment on the roles of industry and academia in moving the field forward. Recollections of Pioneers in Xenotransplantation Research will be of interest to physicians, scientists, and the lay person with an interest in transplantation or in the care of patients with life-threatening diseases, but also to those interested to understand the potential of genetic-engineering in science and medicine. The book provides a historical record of the research that has contributed to an advance in medicine that has been called the next great medical revolution. Within a few years, this new form of therapy is likely to impact every family in the developed world.
| Author | : Jeffrey L. Platt |
| Publisher | : Springer |
| Total Pages | : 210 |
| Release | : 1995 |
| Genre | : Medical |
| ISBN | : |
Hyperacute rejection is defined as rejection of immediate onset which causes the rapid and inexorable decline in function of a vascularized organ graft. Until recently, hyperacute rejection was viewed as the major immunologic hurdle to the clinical application of xenotransplantation. In this monograph, the author conveys a conceptual basis for dealing with the immunological issues and pathogenesis of hyperacute rejection. Annotation copyright by Book News, Inc., Portland, OR
| Author | : Sheila A. M. McLean |
| Publisher | : Routledge |
| Total Pages | : 495 |
| Release | : 2019-07-05 |
| Genre | : Law |
| ISBN | : 1351142704 |
Originally published in 2005. One of the leading causes of death is organ failure, that is, when one or other of the organs that run the machine we call the body gives out. However, whereas with a machine spare parts can usually replace faulty parts, in the case of humans the supply of these is limited as it is dependent on organs being obtained from living or dead donors. Due to the limitations of supply, increasing attention is being paid to alternative schemes for obtaining organs. One of these possibilities is xenotransplantation: using organs from animals. In this book, the authors examine the legal and ethical issues surrounding xenotransplantation and consider the implications for the future. As they point out, xenotransplantation represents a major deviation from standard medical practice and the possibility of transplantation of large segments of tissue, or whole organs, from animals into humans poses an entirely novel set of considerations - ethical, legal and scientific - which it is necessary to evaluate and understand.
