Clinical Trials In Rheumatoid Arthritis And Osteoarthritis
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| Author | : John H. Stone |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 489 |
| Release | : 2009-10-03 |
| Genre | : Medical |
| ISBN | : 1848009348 |
Important strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience. Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of ‘Pearls’ and ‘Myths,’ related to the diseases they call their own, a ‘Pearl’ being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a ‘Myth’ being a commonly held belief that influences the practice of many clinicians – but is false. This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions.
| Author | : David M. Reid |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 323 |
| Release | : 2008-03-20 |
| Genre | : Medical |
| ISBN | : 1846287421 |
Designed to be a practical handbook on clinical trial management in these key therapeutic areas, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed at principal investigators pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases. In the last several years a new classes of biologic agents have emerged and changed the treatment paradigm for patients, not only with classically defined rheumatoid arthritis, but also with other related diseases such as ankylosing spondylitis and psoriatic arthritis. Furthermore, osteoarthritis is a major disease state that is often treated by the rheumatologist, but is one where patient management programs are currently limited with a need for new therapeutic approaches. In both inflammatory and non-inflammatory arthritic conditions, clinical trials have become both large and complex due to the nature of the diseases, with ever-challenging new surrogate end-points being employed. Topics covered in this title will therefore include study design, clinical endpoints, technical issues, data collection, use of centralized medical image reading facilities and biochemical marker laboratories, as well as data analysis and future therapies. This book takes the user through the process step-by-step from start to finish, also providing a background on the regulatory guidelines, ethical implications, endpoints, and current therapies.
| Author | : Paul Emery |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2005 |
| Genre | : Rheumatoid arthritis |
| ISBN | : 9781416027676 |
This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.
| Author | : David T. Felson |
| Publisher | : John Wiley & Sons |
| Total Pages | : 320 |
| Release | : 2010-08-03 |
| Genre | : Medical |
| ISBN | : 9780470930557 |
An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.
| Author | : Alan Hakim |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 674 |
| Release | : 2011-09-22 |
| Genre | : Medical |
| ISBN | : 0199587183 |
This is a handbook of clinical rheumatology that provides practical guidelines to management and diagnosis. It is essential for all specialist registrars and SHO's but will also be of great relevance to general practitioners.
| Author | : Bruce M. Rothschild |
| Publisher | : IntechOpen |
| Total Pages | : 0 |
| Release | : 2012-02-22 |
| Genre | : Medical |
| ISBN | : 9789535100638 |
This volume addresses the nature of the most common form of arthritis in humans. If osteoarthritis is inevitable (only premature death prevents all of us from being afflicted), it seems essential to facilitate its recognition, prevention, options, and indications for treatment. Progress in understanding this disease has occurred with recognition that it is not simply a degenerative joint disease. Causative factors, such as joint malalignment, ligamentous abnormalities, overuse, and biomechanical and metabolic factors have been recognized as amenable to intervention; genetic factors, less so; with metabolic diseases, intermediate. Its diagnosis is based on recognition of overgrowth of bone at joint margins. This contrasts with overgrowth of bone at vertebral margins, which is not a symptomatic phenomenon and has been renamed spondylosis deformans. Osteoarthritis describes an abnormality of joints, but the severity does not necessarily produce pain. The patient and his/her symptoms need to be treated, not the x-ray.
| Author | : Lynne S. Peterson |
| Publisher | : Rosetta Books |
| Total Pages | : 499 |
| Release | : 2020-09-08 |
| Genre | : Health & Fitness |
| ISBN | : 0795352883 |
A guide to living well with this common—and complex—condition from“one of the most reliable, respected health resources that Americans have” (Publishers Weekly). From the doctors at Mayo Clinic—the top-ranked hospital in the country according to US News & World Report—this book is a complete guide to understanding and living with arthritis. Find the latest expertise on various forms of arthritis, medications and other treatment options, and self-care to successfully manage joint pain and stay active and independent. If you have joint pain, you know it can lead to frustrating limitations in daily life. In fact, this complex group of joint diseases—osteoarthritis, rheumatoid arthritis, and many other forms—is the most common cause of disability in the United States. But living with it doesn’t have to mean sitting on the sidelines. This book offers the same expert knowledge that Mayo Clinic doctors, nurses and therapists use in caring for patients. Mayo Clinic Guide to Arthritis: • Breaks down different forms of arthritis and joint pain to help you understand their causes, their signs and symptoms, and what each may mean for your health • Explores the latest in arthritis treatments, including new medications to slow or stop the disease, improved options for joint surgery, joint injections, and evidence-based guidance on pain control and integrative medicine • Provides practical tips for living with arthritis while exercising, traveling, or working • Offers useful advice on diet, mental health, and protecting your joints
| Author | : J.-Y. Reginster |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 790 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642600263 |
Musculoskeletal diseases are rapidly becoming a major health concern. The incidence of osteoarthritis, the most common arthritic disorder, is increasing steadily due to the graying of the world population. This disease is responsible of human life, a time in for significant morbidity, particularly in the second half which the quality of life is of primary importance. The aim of this publication is to bring to physicians and scientists a comprehensive overview of the field, from molecules to men. The direct costs related to osteoarthritis have been increasing steadily over the years and will soon be comparable to those of other major illnesses, such as cardiovascular diseases. This, of course, does not take into account all of the other costs related to the disease which often cannot be simply calculated in dollars and cents. There has been a great deal of renewed interest in osteoarthritis in the last few decades. This has been brought on by the need to improve our knowledge of all aspects of the disease, especially with regard to its etiopathogenesis and treatment. The most recent findings and developments on the structural, bio chemical, biomechanical and molecular changes observed in clinical and ex perimental osteoarthritis are presented in this book.
| Author | : Nigel Arden |
| Publisher | : Springer |
| Total Pages | : 99 |
| Release | : 2015-01-19 |
| Genre | : Medical |
| ISBN | : 1910315168 |
This Atlas provides an up-to-date and comprehensive overview of the historical and current perspectives on osteoarthritis, including the pathophysiology and epidemiology of the disease. Written by leading authors in the field of osteoarthritis, the book discusses classification, etiology and risk factors for osteoarthritis, the disease course and determinants of osteoarthritis progression, clinical features and diagnosis as well as imaging methods to assess joint damage. The Atlas of Osteoarthritis concludes with the latest treatment updates including both nonpharmacological and pharmacological treatments, as well as surgical recommendations for patients with the disease. Osteoarthritis is the most common form of joint disease causing joint pain, stiffness, and physical disability among adults. It is an important issue for both the individual and society with its impact on public health continuing to grow as a result of the aging population, the rising prevalence of obesity, and the lack of definitive treatments to prevent or halt the progress of the disease.
| Author | : Paul C. Guest |
| Publisher | : Springer |
| Total Pages | : 381 |
| Release | : 2021-06-20 |
| Genre | : Science |
| ISBN | : 9783030561529 |
The Middle East is known as the cradle of civilization. It was the crossroads of ancient empires and the birthplace of major world religions. Today it is the center of many world issues due to its economic, religious and political importance. Although it has lagged behind many other regions of the world in medicinal research, this has increased dramatically in recent years with increasing numbers of relevant publications and the country of Iran has spearheaded this progress. Much of the research has focused on increasing our understanding of the aging process and attempting to identify biomarkers and natural products to improve the human healthspan. This book provides a comprehensive overview of the research conducted in the Middle East on the health benefits of curcumin, a phytochemical derived from the famous spice turmeric. Hundreds of studies have now been published describing the health benefits of this spice. The importance of this research is exemplified by poor data regarding health and longevity as only 0.08% of the population in Iran consists of individuals over 90 years of age. This is approximately 10 times lower than the percentage of this same age group in the United Kingdom and the United States of America and almost 20 times lower than that in Japan. This book presents a series of reviews and meta-studies describing research which has resulted in identification potential new biomarkers and drug targets for age-related disorders. All of the studies have focussed on the testing of curcumin and related products, which have already shown some promising leads in age-related conditions such as heart-disease, diabetes, cognitive impairment and cancer. The authors in this series come from different centers and cities of Iran, including Mashhad, Tehran, Isfahan, Ahvaz, Birjand, Quchan and Yazd, and many of the chapters feature collaborations with other countries of the Middle East and throughout the world, including Brazil, Italy, Mexico, Oman, Poland, Switzerland, the United Kingdom and the United States of America. This underscores the emergence of the Middle East into this arena of research. The book will be of high interest to scientific and clinical researchers in the subject of aging and age-related disease, and to physicians and pharmaceutical company scientists since it gives insights into the latest strategies, biomarkers and targets involved in the mechanism of action of curcumin to promote healthy aging. It will also provide important information on disease mechanisms related to age-related disorders, as each chapter will be presented in the context of specific chronic diseases.
