Clinical Pharmacology Current Topics And Case Studies
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Author | : Markus Müller |
Publisher | : Springer Science & Business Media |
Total Pages | : 438 |
Release | : 2011-02-04 |
Genre | : Medical |
ISBN | : 3709101441 |
Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.
Author | : Bernd Meibohm |
Publisher | : John Wiley & Sons |
Total Pages | : 426 |
Release | : 2006-12-13 |
Genre | : Science |
ISBN | : 3527609520 |
This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.
Author | : Robert F. Maronde |
Publisher | : Springer Science & Business Media |
Total Pages | : 528 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461248647 |
Dr. Maronde has performed a major service in bringing together a superb array of scholars and clinicians to discuss not only the basic principles in therapeutics and clinical pharmacology but also the application of those principles to a wide range of clinical problems. Inclusion of chapters on adverse drug reactions, drug overdose, nonmedical prescription drug use, physician prescribing patterns, and the pharmaceutical industry makes this a particularly valuable book for clinicians. It is increasingly important that clinicians be well grounded in the principles of pharmacodynamics and pharmacokinetics because more and more of our patients are aging and cannot be treated as young or middle-aged adults. Elderly patients are liable to either drug overdose or underdose if traditional dosage formulas are followed because of changes in drug metabolism, drug distribution within the body, drug excretion, or changes in receptor site sensitivity. Because the elderly often present with mUltiple chronic diseases and require a variety of medications, they are more prone to medication errors, drug-drug interactions, and adverse drug reactions. The inclusion of three excellent chapters relating to drug-drug interactions, adverse drug reactions, and drug overdose is most welcome and is a valuable addition to this outstanding text on therapeutics and clinical pharmacology. Adverse drug reactions present a potentially serious problem for any patient for whom drugs are prescribed and particularly for those who must take multiple prescriptions.
Author | : Michelle Cleary |
Publisher | : Human Kinetics |
Total Pages | : 371 |
Release | : 2021-10-12 |
Genre | : Medical |
ISBN | : 1492594199 |
Athletic trainers have a responsibility to provide high-quality pharmaceutical care while meeting both legal and ethical requirements. Clinical Pharmacology in Athletic Training empowers athletic trainers with a functional understanding of pharmacology that enables them to formulate a treatment plan intended to mitigate disease and improve the overall health of their patients. This text incorporates the most up-to-date content from the 2020 Commission on Accreditation of Athletic Training Education (CAATE) standards, and it emphasizes interprofessional practice to enable future and current athletic trainers to collaborate with other health professionals in a manner that optimizes the quality of care. Clinical Pharmacology in Athletic Training begins by addressing drug legislation and the legal aspects of the athletic trainer’s role in sport medication. The text provides an overview of pharmacokinetics and pharmacodynamics with an emphasis on concepts relevant to clinical practice. Students are introduced to the generic and brand names, general classifications, and appropriate administration of drugs and are guided toward appropriate online reference materials. Part II of this text describes common medications for pain, inflammation, and infections. Part III includes medications for specific conditions, including respiratory, cardiovascular, gastrointestinal, neurological, gynecological, and mental health conditions. The text also includes current information on opioid analgesics, cannabis, and cannabinoid-based medications. Clinical Pharmacology in Athletic Training teaches students to administer appropriate pharmacological agents for the management of the patient’s condition. The information includes indications, contraindications, dosing, interactions, and adverse reactions. The following features are included to aid in the learning process: Chapter objectives set the stage for the main topics covered in the chapter. Key terms are boldfaced to indicate terms of special importance, and a glossary of definitions is included at the back of the book. Red Flag sidebars highlight warnings and precautions for certain medications or medicolegal issues. Evidence in Pharmacology sidebars highlight recent research regarding medications. Clinical Application sidebars present real-life stories from the field of athletic training. Case studies highlight specific therapeutic medication applications and are accompanied by questions that prompt readers to think critically about the issues presented. Quick reference drug tables describe medication types, generic and brand names, pronunciations, common indications, and other special considerations for the athletic trainer. Over the past decade, there has been an increased emphasis on pharmacology in athletic training. Clinical Pharmacology in Athletic Training will equip students with appropriate skills and competencies, prepare them to meet patient needs, and enable them to work in interprofessional teams.
Author | : Marcia Moeller Grant |
Publisher | : |
Total Pages | : 169 |
Release | : 1977 |
Genre | : Chemotherapy |
ISBN | : 9780803642805 |
Author | : Kerry Layne |
Publisher | : CRC Press |
Total Pages | : 249 |
Release | : 2020-01-29 |
Genre | : Medical |
ISBN | : 0429624972 |
100 Cases in Clinical Pharmacology, Therapeutics and Prescribing explores scenarios commonly seen by medical students and junior doctors in the ward, emergency department, outpatient clinic or in general practice in which an understanding of pharmacology and sound prescribing practice is central to successful clinical management and safe patient care. A succinct summary of the patient’s history, examination and any initial investigations is followed by questions on the diagnosis and management of the case. The answer includes a detailed discussion on each topic, providing practical advice on how to deal with the challenges that occur when prescribing, including planning, drug calculations, prescription review and adverse drug reactions. The book will be invaluable during clinical placements and is an ideal companion during preparation for the Prescribing Safety Assessment examination. Making speedy and appropriate clinical decisions, and choosing the best course of action to take as a result, is one of the most important and challenging parts of training to become a doctor. These true-to-life cases will teach students and junior doctors to prescribe appropriately, and to hone their diagnostic and management skills.
Author | : Shiew-Mei Huang |
Publisher | : Academic Press |
Total Pages | : 649 |
Release | : 2012-09-18 |
Genre | : Medical |
ISBN | : 0123854725 |
Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science. The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions Offers an expanded regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III
Author | : Roger Walker (Ph. D.) |
Publisher | : |
Total Pages | : 956 |
Release | : 2003 |
Genre | : Medical |
ISBN | : |
The new edition of this popular, well-established textbook addresses the expanding role of the pharmacist in treating patients. It covers treatment of common diseases as well as other medical, therapeutic and patient related issues. Written by both pharmacists and clinicians to reflect a team approach, it offers an in-depth analysis of drug therapy in the treatment of disease, relying on input from the pharmacist as a member of the "team" in hospital and community settings. Information is easy to locate in a logical format organized primarily by systems and disorders.
Author | : Al Rundio |
Publisher | : |
Total Pages | : |
Release | : 2015-11-15 |
Genre | : |
ISBN | : 9781935213680 |
Author | : Shiew-Mei Huang |
Publisher | : Academic Press |
Total Pages | : 764 |
Release | : 2021-10-16 |
Genre | : Medical |
ISBN | : 0128198842 |
Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK