Clinical Neuroendocrinology Neuropeptide Gpcrs
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Author | : David Murphy |
Publisher | : John Wiley & Sons |
Total Pages | : 682 |
Release | : 2016-01-19 |
Genre | : Science |
ISBN | : 1119162181 |
Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems. The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today’s neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers • Both print and enhanced e-book versions are available • Illustrated in full colour throughout This is the third volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA
Author | : Jae Young Seong |
Publisher | : Frontiers E-books |
Total Pages | : 826 |
Release | : 2014-11-07 |
Genre | : Diseases of the endocrine glands. Clinical endocrinology |
ISBN | : 2889192679 |
The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
Author | : Maria Lucia Narducci |
Publisher | : Frontiers Media SA |
Total Pages | : 397 |
Release | : 2023-07-07 |
Genre | : Medical |
ISBN | : 2832529240 |
Author | : Michael Wilkinson |
Publisher | : Cambridge University Press |
Total Pages | : 207 |
Release | : 2019-01-03 |
Genre | : Medical |
ISBN | : 1316645193 |
A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.
Author | : |
Publisher | : Cambridge University Press |
Total Pages | : 501 |
Release | : |
Genre | : |
ISBN | : 052180647X |
Author | : Jeff M. P. Holly |
Publisher | : Frontiers Media SA |
Total Pages | : 163 |
Release | : 2020-01-30 |
Genre | : |
ISBN | : 2889633926 |
Author | : Richard E. Brown |
Publisher | : Cambridge University Press |
Total Pages | : 434 |
Release | : 1994-01-27 |
Genre | : Medical |
ISBN | : 9780521426657 |
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Author | : Eduardo A. Nillni |
Publisher | : Springer |
Total Pages | : 379 |
Release | : 2018-07-20 |
Genre | : Medical |
ISBN | : 3319895060 |
This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.
Author | : Olivier Civelli |
Publisher | : Springer Science & Business Media |
Total Pages | : 267 |
Release | : 2008-05-15 |
Genre | : Science |
ISBN | : 3540783512 |
Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.
Author | : Mark A. Sperling |
Publisher | : Elsevier Health Sciences |
Total Pages | : 909 |
Release | : 2008-06-05 |
Genre | : Medical |
ISBN | : 143771109X |
Completely updated, the new edition of this easy-to-reference text examines the physiological, biochemical, and genetic aspects of pediatric endocrine disorders. Leaders in the field discuss the hottest topics-including genetics, diabetes and obesity-impacting today’s endocrine practice, keeping you up to date. A user-friendly organization speeds you to the information you need, and conceptual illustrations and photographs depict the latest advances with consistency and clarity. It’s the guidance you need to provide effective, state-of-the-art care for your pediatric and neonatal patients. Examines the physiological, biochemical, and genetic aspects of endocrine disorders all in one convenient reference. Incorporates the importance of molecular biology as it relates to developmental and pediatric endocrinology. Offers expanded coverage of genetics, diabetes and obesity-topics of increasing concern in pediatric endocrinology today. Presents the work of many new contributors for fresh perspectives on the current state of pediatric endocrinology. Provides new tables of normal values and growth charts for monitoring your patients’ progress. Concepts, Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests and Imaging-making the material easy to navigate.