Clinical Metagenomics Based Diagnostics For Infectious Diseases
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| Author | : Anil Agarwal |
| Publisher | : JP Medical Ltd |
| Total Pages | : 210 |
| Release | : 2013-01-30 |
| Genre | : Medical |
| ISBN | : 9350902893 |
This concise guide brings orthopaedic surgeons and paediatricians up to date with the latest developments in the management of bone and joint (osteoarticular) infections in children. Beginning with an introduction to the causes and development of osteoarticular disorders, the following chapters discuss their clinical features, laboratory diagnosis and treatment options, both surgical and conservative. Each chapter describes a different infection and its management, with a separate chapter examining drug-resistant osteoarticular tuberculosis and co-infection with HIV. The final section discusses advances and research in the condition. Key points Concise guide to the diagnosis and management of bone and joint infections in children Each chapter discusses a different infection and covers conservative and surgical treatment Final chapter describes new advances and research Includes more than 150 full colour images and illustrations
| Author | : Sathyavathi Sundararaju |
| Publisher | : Frontiers Media SA |
| Total Pages | : 281 |
| Release | : 2024-08-20 |
| Genre | : Science |
| ISBN | : 2832553354 |
Clinical metagenomics is an emerging method in the diagnosis of infectious diseases that uses next generation sequencing (NGS) technology to identify the etiologic agents to allow for more effective and targeted treatment of infectious diseases. Conventional diagnostic methods are mainly based on basic morphologic, phenotypic and genotypic analyses which can be insensitive and/or time consuming. Metagenomic NGS (mNGS) can be performed with only a small amount of nucleic acid from the specimen and not only can the pathogen be identified and characterized, but also its antimicrobial susceptibility can be inferred. Although tremendous advancements were made in the speed, throughput, and cost of NGS in recent years, the application of clinical metagenomics in routine diagnosis of infectious diseases is not yet practical because of its much higher cost compared to conventional microbiological tests, complex laboratory workflows and computational challenges.
| Author | : Harald H. Kessler |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 243 |
| Release | : 2014-07-28 |
| Genre | : Medical |
| ISBN | : 3110373475 |
The prevalence of infectious diseases is worldwide increasing. Therefore, detection methods for infectious pathogens change quickly. In the 3rd edition of Kessler ́s Molecular Diagnostics of Infectious Diseases laboratory professionalists get valueable information about the current diagnostic methods, tipps and tricks in terms of sample processing, quality control, and interpretation of the results. For clinicians the book is a valuable aid for decision-making in ordering appropriate tests as well as in assuring the necessary quality of the sample material.
| Author | : Jacques Izard |
| Publisher | : Academic Press |
| Total Pages | : 188 |
| Release | : 2014-11-07 |
| Genre | : Science |
| ISBN | : 0124105084 |
Concisely discussing the application of high throughput analysis to move forward our understanding of microbial principles, Metagenomics for Microbiology provides a solid base for the design and analysis of omics studies for the characterization of microbial consortia. The intended audience includes clinical and environmental microbiologists, molecular biologists, infectious disease experts, statisticians, biostatisticians, and public health scientists. This book focuses on the technological underpinnings of metagenomic approaches and their conceptual and practical applications. With the next-generation genomic sequencing revolution increasingly permitting researchers to decipher the coding information of the microbes living with us, we now have a unique capacity to compare multiple sites within individuals and at higher resolution and greater throughput than hitherto possible. The recent articulation of this paradigm points to unique possibilities for investigation of our dynamic relationship with these cellular communities, and excitingly the probing of their therapeutic potential in disease prevention or treatment of the future. - Expertly describes the latest metagenomic methodologies and best-practices, from sample collection to data analysis for taxonomic, whole shotgun metagenomic, and metatranscriptomic studies - Includes clear-headed pointers and quick starts to direct research efforts and increase study efficacy, eschewing ponderous prose - Presented topics include sample collection and preparation, data generation and quality control, third generation sequencing, advances in computational analyses of shotgun metagenomic sequence data, taxonomic profiling of shotgun data, hypothesis testing, and mathematical and computational analysis of longitudinal data and time series. Past-examples and prospects are provided to contextualize the applications.
| Author | : Parvizi Javad |
| Publisher | : JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD. |
| Total Pages | : 432 |
| Release | : 2013-12-15 |
| Genre | : Medical |
| ISBN | : 9350908255 |
This book Periprosthetic Joint Infection is a portable guide to the practical management of surgical site infections following orthopedic procedures. It designed to help answer clinician's questions regarding the prevention and treatment of periprosthetic infections. It organized for rapid review, featuring evidence reviews, pitfalls, Rothman Institute Current Practices and Controversies. The guide is being included in the course materials for the 29th Annual Current Concepts in Joint Replacement® (CCJR) meeting thanks to a generous educational grant from 3M Health Care.
| Author | : W. Zimmerli |
| Publisher | : John Wiley & Sons |
| Total Pages | : 429 |
| Release | : 2015-01-27 |
| Genre | : Science |
| ISBN | : 1118581776 |
Infections of the bones (osteomyelitis) and joints (septic arthritis) are serious health problems which require antibiotics and often surgery. Awareness among health professionals of the causes and treatment options for various types of bone and joint infections is essential for effective resolution. Bone and Joint Infections takes a multidisciplinary approach in covering the diagnostic and therapeutic treatment of osteomyelitis and septic arthritis, including different types of implant-associated infections. Correct and rapid diagnosis of bone and joint infection is crucial, and requires the input of a variety of specialists. Bone and Joint Infection takes a similarly collaborative and comprehensive approach, including chapters authored by clinicians, laboratory specialists, and surgeons. Covering the basic microbiology and clinical aspects of bone and joint infection, this book will be a valuable resource both for researchers in the lab and for physicians and surgeons seeking a comprehensive reference on osteomyelitis and septic arthritis.
| Author | : Richard L. Kradin |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 715 |
| Release | : 2017-04-26 |
| Genre | : Medical |
| ISBN | : 0323508677 |
Comprehensive and up to date, the Second Edition of Diagnostic Pathology: Infectious Disease, by Dr. Richard Kradin, is an invaluable tool for the accurate diagnosis of any infectious disease―from the common to the most challenging. The organ-based format makes it an especially useful tool for surgical pathologists' daily diagnostic and management issues. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion, clearly depicting how to recognize the morphology of organisms and the spectrum of histological responses that they may cause. - Addresses the most difficult diagnostic issues that practicing or trainee surgical pathologists face when handling infectious disease tissue specimens. - Highlights morphological characteristics and landmarks of tissue samples for easy access to information necessary for signing out a specimen. - Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. - Completely revised with the latest diagnostic support and hot topics in the field: - A new chapter on novel techniques in microbiology - A new chapter on eye infections - New coverage of immunohistochemical staining and other molecular diagnostic techniques - New discussions of human papillomavirus, a critical tool in predictive cancer screening - New information on infections in the immunocompromised host and related special considerations - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
| Author | : Rosa Estela Quiroz Castañeda |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 200 |
| Release | : 2018-03-21 |
| Genre | : Medical |
| ISBN | : 9535139118 |
The scope of this book is to present the most recent trends based on omic analyses of microorganisms causing diseases in farm animals and how these approaches result in new strategies of treatment. The topics in this book include fasciolosis, avian coccidiosis, bovine anaplasmosis, tick-borne diseases, and babesiosis, among others. This book presents the recent advances in the omic field with an emphasis on how these analyses have led researchers to know the mechanisms that pathogens use to invade and colonize the host cell of farm animals. In this way, new treatments of control and prevention can be employed.
| Author | : David H. Persing |
| Publisher | : John Wiley & Sons |
| Total Pages | : 852 |
| Release | : 2020-07-24 |
| Genre | : Science |
| ISBN | : 1555819079 |
Presenting the latest molecular diagnostic techniques in one comprehensive volume The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field. Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice Presents the latest basic scientific theory underlying molecular diagnostics Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing Illustrates and summarizes key concepts and techniques with detailed figures and tables Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance Advises on the latest quality control and quality assurance measures Explores the increasing opportunities and capabilities of information technology Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 473 |
| Release | : 2015-12-29 |
| Genre | : Medical |
| ISBN | : 0309377722 |
Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.
