Clinical Applications Of Mifepristone Ru486 And Other Antiprogestins
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| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 303 |
| Release | : 1993-02-01 |
| Genre | : Medical |
| ISBN | : 0309049490 |
Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with likely applicability to a variety of pregnancy-related conditions (e.g., management of labor) and to contraception, endometriosis, and cancer, among others. But because mifepristone has been studied and used most widely as a means of nonsurgical abortion, political issues have thus far limited research on the drug and prevented its introduction into the U.S. market. This book provides an unbiased evaluation of current knowledge about both the fundamental nature of antiprogestins as well as their possible use in treating numerous diseases and conditions, and it contains recommendations for future research.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 534 |
| Release | : 1996-11-04 |
| Genre | : Medical |
| ISBN | : 0309175658 |
The "contraceptive revolution" of the 1960s and 1970s introduced totally new contraceptive options and launched an era of research and product development. Yet by the late 1980s, conditions had changed and improvements in contraceptive products, while very important in relation to improved oral contraceptives, IUDs, implants, and injectables, had become primarily incremental. Is it time for a second contraceptive revolution and how might it happen? Contraceptive Research and Development explores the frontiers of science where the contraceptives of the future are likely to be found and lays out criteria for deciding where to make the next R&D investments. The book comprehensively examines today's contraceptive needs, identifies "niches" in those needs that seem most readily translatable into market terms, and scrutinizes issues that shape the market: method side effects and contraceptive failure, the challenge of HIV/AIDS and other sexually transmitted diseases, and the implications of the "women's agenda." Contraceptive Research and Development analyzes the response of the pharmaceutical industry to current dynamics in regulation, liability, public opinion, and the economics of the health sector and offers an integrated set of recommendations for public- and private-sector action to meet a whole new generation of demand.
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 223 |
| Release | : 2018-06-24 |
| Genre | : Medical |
| ISBN | : 0309468183 |
Abortion is a legal medical procedure that has been provided to millions of American women. Since the Institute of Medicine first reviewed the health implications of national legalized abortion in 1975, there has been a plethora of related scientific research, including well-designed randomized clinical trials, systematic reviews, and epidemiological studies examining abortion care. This research has focused on examining the relative safety of abortion methods and the appropriateness of methods for different clinical circumstances. With this growing body of research, earlier abortion methods have been refined, discontinued, and new approaches have been developed. The Safety and Quality of Abortion Care in the United States offers a comprehensive review of the current state of the science related to the provision of safe, high-quality abortion services in the United States. This report considers 8 research questions and presents conclusions, including gaps in research.
| Author | : Etienne-Emile Baulieu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 347 |
| Release | : 2013-03-09 |
| Genre | : Nature |
| ISBN | : 1468412426 |
Advances in basic biological research have proceeded rapidly in recent years. The fields of molecular genetics and immunology have experienced dramatic breakthroughs, capturing the imagination of both the scientific community and the general public. With less public notice, receptor biology has brought a cascade of new discoveries and insights. The entire science of pharmacology has been virtually rewritten in terms of receptor phenomenology. In particular, the discovery of specific receptors for steroid and protein hormones has been of seminal importance. With this new information, we have advanced our understanding of the mechanism and specifity of hormone action. We can now explain how hormones interact selectively with specific target cells and how hormones alter biochemical events within the target cells. These facts have already impacted on applied problems of clinical medicine, particularly in diagnosis and treatment of cancer and some metabolic diseases. Now, a new and important application of basic receptor biology and chemistry looms ahead. Within a few short years since the discovery of the progesterone receptor, chemists have synthesized molecules with a greater affinity for the receptor than progesterone itself and which, while occupying the receptor, fail to trigger the events which transform a target cell from the unstimulated to the stimulated state. This is the basis of the competitive inhibitory action of the anti-progestational agent, synthesized by the chemists at Roussel Uc1af, Paris, and designated RU 486.
| Author | : Christopher Sutton |
| Publisher | : Cambridge University Press |
| Total Pages | : 105 |
| Release | : 2004-05-01 |
| Genre | : Medical |
| ISBN | : 1107783224 |
Endometriosis affects a huge number of women throughout the world. It has been estimated that between 1% and 15% of women who are examined for pelvic pain and infertility may have endometriosis; the true prevalence is unknown because diagnosis can only be made with any accuracy by laparoscopic examination of the pelvis. This book provides clinicians with all the information they need in a succinct and clear text, with colour illustrations. Chapters cover: epidemiology and aetiology; diagnosis; investigation; medical treatment; and surgical treatment.
| Author | : Carlo Bulletti |
| Publisher | : |
| Total Pages | : 520 |
| Release | : 1991 |
| Genre | : Medical |
| ISBN | : |
| Author | : Vera Regitz-Zagrosek |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 599 |
| Release | : 2012-10-02 |
| Genre | : Medical |
| ISBN | : 3642307264 |
This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.
| Author | : Andrew T. Goldstein |
| Publisher | : John Wiley & Sons |
| Total Pages | : 431 |
| Release | : 2011-09-23 |
| Genre | : Medical |
| ISBN | : 1444356658 |
First book devoted to the diagnosis and treatment of sexual pain in women Female Sexual Pain Disorders is a remarkable fusion of clinical and scientific knowledge that will empower women’s healthcare professionals to help their patients in overcoming this common debilitating disorder. Based on the highest level research, it provides state-of-the-art practical guidance that will help you to: Evaluate and distinguish the causes of sexual pain in women Differentiate the many forms of sexual pain Implement multidisciplinary treatments Distilling the experience of world leaders across many clinical, therapeutic and scientific disciplines, with an array of algorithms and diagnostic tools, Female Sexual Pain Disorders is your ideal companion for treating the many millions of women who suffer from this disorder worldwide. All proceeds from this book are being donated to the International Society for the Study of Women’s Sexual Health (ISSWSH).
| Author | : Axel I. Mundigo |
| Publisher | : |
| Total Pages | : 508 |
| Release | : 1999 |
| Genre | : Medical |
| ISBN | : |
Twenty million unsafe abortions are performed each year, 90% of which occur in the developing world. Even in countries such as China, where abortion is fully accessible in practice as well as in theory, our understanding of the phenomenon is very partial. The result of a global research project commissioned by the World Health Organization, this book provides new information on abortion, why it happens and what happens when it does. There are sections detailing women' s perspectives and also chronicling the providers views and the effect they have on medical provision. Several essays focus on the relationship between contraception and abortion, while a section on adolescents addresses a newly emerging concern for program managers around the world. Including much previously unavailable material, this book is the most comprehensive and up-to-date picture of abortion globally.
| Author | : Goran Augustin |
| Publisher | : Springer |
| Total Pages | : 853 |
| Release | : 2018-09-14 |
| Genre | : Medical |
| ISBN | : 3319729950 |
This is the second edition of a well-received book that reflects the state of the art in diagnosis and treatment of acute abdominal disorders in the pregnant patient. It addresses a wide range of conditions - whether associated with or incidental to pregnancy - ranging from very rare to more common ones, such as acute appendicitis and acute cholecystitis. It offers an update on recommendations, guidelines and scenarios to provide fundamental support for all clinicians who might encounter such cases. The book highlights the importance of a rapid diagnosis to avoid serious consequences for both the mother and the fetus. Furthermore, it sheds light on the different imaging modalities of rare pathologies that can occur during pregnancy, helping clinicians and radiologists to better define underlying cases. This new edition has been almost completely rewritten, and includes an additional section focusing on urologic emergencies, preterm labor and intra-abdominal pressure, as well as new figures and tables. It is equally valuable for general and abdominal surgeons, gynecologists and obstetricians, as well as emergency physicians, who may be the first specialists to have clinical contact with this group of patients.
