Clinical And Experimental Pathology Of Lung Cancer
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| Author | : J. Gordon McVie |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 189 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 9400950365 |
J. G. MCVIE The impact of therapy on one subset of lung cancer, the "small cell" type has been significant and lasting. The reality of cure for even a fraction of patients with this disease has caused reverberations in the pathology lab where the responsibili. '~y and challenge of diagnosis of this vital sub group lies. No less dramatic has been the discovery that the cell types of lung cancer have recognisable growth characteristics in serum free culture, they are recognisable by patterns of markers and some produce growth factors which autoregulate their eventual fate. Many of the discoveries from the biological studies have impacted on the pathologist in the form of disturbing evidence for a single stem cell origin for all the cell types of lung cancer and in the shape of new facilitation in diagnosis by appli cation of immunoperoxidase techniques. Monoclonal antibodies raised against oncogene products, growth factor receptor sites, "bystander" cell membrane proteins can all be applied to cytology specimens and frozen or paraffin fixed tissue sections to aid diagnosis and some can be used in sequential serum assay to monitor therapy and predict prognosis. Adding to these extraordinary tools, the sophistication of electron micro scopy and immuno-electrcn microscopy, new techniques for preparation of tissue and novel methods for studying vital cells in "kinesis", you sense the flavour of the future of lung cancer which is captured in this book.
| Author | : Aamir Ahmad |
| Publisher | : Springer |
| Total Pages | : 236 |
| Release | : 2015-12-14 |
| Genre | : Medical |
| ISBN | : 3319242237 |
This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
| Author | : J Gordon McVie |
| Publisher | : |
| Total Pages | : 204 |
| Release | : 1985-12-31 |
| Genre | : |
| ISBN | : 9789400950375 |
| Author | : Philip T. Cagle |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 217 |
| Release | : 2012-06-14 |
| Genre | : Medical |
| ISBN | : 1461431972 |
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
| Author | : United States. Public Health Service. Office of the Surgeon General |
| Publisher | : |
| Total Pages | : 728 |
| Release | : 2010 |
| Genre | : Government publications |
| ISBN | : |
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
| Author | : Emmanuel E. Coche |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 472 |
| Release | : 2011-01-18 |
| Genre | : Medical |
| ISBN | : 3540799427 |
Standard radiography of the chest remains one of the most widely used imaging modalities but it can be difficult to interpret. The possibility of producing cross-sectional, reformatted 2D and 3D images with CT makes this technique an ideal tool for reinterpreting standard radiography of the chest. The aim of this book is to provide a comprehensive overview of chest radiography interpretation by means of a side-by-side comparison between chest radiographs and CT images. Introductory chapters address the indications for and difficulties of chest radiography as well as the technical and practical aspects of CT reconstruction and image comparison. Thereafter, the radiographic and CT presentations of both anatomical variants and a wide range of diseases and disorders are illustrated and discussed by renowned experts in thoracic imaging. The book is complemented by online extra material which provides many further educational examples.
| Author | : René Holzheimer |
| Publisher | : |
| Total Pages | : 880 |
| Release | : 2001 |
| Genre | : Medical |
| ISBN | : |
| Author | : Philip Hasleton |
| Publisher | : Cambridge University Press |
| Total Pages | : 4616 |
| Release | : 2013-01-17 |
| Genre | : Medical |
| ISBN | : 1139618970 |
Fully rewritten and updated for the cutting-edge sixth edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Downloadable versions of all images are available on a CD-ROM packaged with the print book. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.
| Author | : Ming Zhou |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 723 |
| Release | : 2014-10-20 |
| Genre | : Medical |
| ISBN | : 0323188338 |
Genitourinary Pathology, by Drs. Ming Zhou and Cristina Magi-Galluzzi, a volume in the Foundations in Diagnostic Pathology Series, packs all of today's most essential information on genitourinary pathology into a compact, high-yield format! Well-organized and segmented by type of infectious organism, the book's pragmatic approach complemented by abundant full-color, high-quality photomicrographs and clinical photos, and at-a-glance tables makes it easy to access the information you need to quickly and accurately detect and identify molecular and genetic mechanisms of disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Easily review normal histology before examining abnormal findings so you can avoid false positives. Gain a superb visual understanding of important histologic features with hundreds of full-color illustrations representing a wide variety of pathologic lesions. Benefit from the same highly practical format as other titles in this series: consistent headings throughout, summary boxes for pathologic and clinical features, high quality photomicrographs and clinical photos, and a logical organization by type of infectious organism. Avoid incorrect diagnoses with a separate section on artifacts and pitfalls that highlights common problems you may encounter. Get up-to-date, comprehensive coverage of the field, including new renal cell carcinoma subtypes and intraductal carcinoma of the prostate; newer immunohistochemical and molecular markers; and updates to the Gleason Grading system for prostate cancer, Fuhrman Grading system for renal cell carcinoma, and TNM classification for GU malignancies.
| Author | : National Library of Medicine (U.S.) |
| Publisher | : |
| Total Pages | : 1676 |
| Release | : |
| Genre | : Medicine |
| ISBN | : |
First multi-year cumulation covers six years: 1965-70.
