Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics
Author: Anita Göndör
Publisher: Academic Press
Total Pages: 498
Release: 2016-10-25
Genre: Science
ISBN: 0128034025

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. - Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective - Promotes crosstalk between basic sciences and their applications in medicine - Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles - Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation
Author: Vincenzo E. A. Russo
Publisher:
Total Pages: 716
Release: 1996
Genre: Medical
ISBN:

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

The Structure and Function of Chromatin

The Structure and Function of Chromatin
Author: David W. FitzSimons
Publisher: John Wiley & Sons
Total Pages: 192
Release: 2009-09-16
Genre: Science
ISBN: 0470717785

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author: Suming Huang
Publisher: Academic Press
Total Pages: 484
Release: 2015-10-19
Genre: Science
ISBN: 0128004711

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. - Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies - Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring - Chapters are replete with clinical examples to empower the basic biology with translational significance - Offers more than 100 illustrations to distill key concepts and decipher complex science

The Nucleosome

The Nucleosome
Author: A.P. Wolffe
Publisher: Elsevier
Total Pages: 265
Release: 1996-01-08
Genre: Science
ISBN: 0080537847

This is the first in a series of volumes concerning the properties of the eukaryotic nucleus. Contributions from several of the most active laboratories are brought together to present a focused overview of a selected aspect of nuclear structure and function.

Epigenetic Contributions in Autoimmune Disease

Epigenetic Contributions in Autoimmune Disease
Author: Esteban Ballestar
Publisher: Springer
Total Pages: 182
Release: 2011-08-23
Genre: Medical
ISBN: 9781441982179

This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.

Chromatin Structure and Gene Expression

Chromatin Structure and Gene Expression
Author: Sarah C. R. Elgin
Publisher: Frontiers in Molecular Biology
Total Pages: 372
Release: 2000
Genre: Chromatin
ISBN: 9780199638901

Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.

Long-Range Control of Gene Expression

Long-Range Control of Gene Expression
Author: Veronica van Heyningen
Publisher: Academic Press
Total Pages: 415
Release: 2011-09-02
Genre: Science
ISBN: 0080877818

Long-Range Control of Gene Expression covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced. Discusses the evolution of cis-regulatory sequences in drosophila Includes information on genomic imprinting and imprinting defects in humans Includes a chapter on epigenetic gene regulation in cancer

Fundamentals of Chromatin

Fundamentals of Chromatin
Author: Jerry L. Workman
Publisher: Springer Science & Business Media
Total Pages: 594
Release: 2013-12-04
Genre: Medical
ISBN: 1461486246

​​​​​​​​​​​​​While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.