In recent decades, agrochemicals have enhanced crop productivity to meet increasing global food requirements. However, prolonged and extensive use of agrochemicals has resulted in contamination that persists in the soil system which can be biomagnified in the food chain. Furthermore, toxic chemicals adversely affect important soil microbial biota, the key drivers of biogeochemical cycles. This concern has raised the need to develop environmentally friendly and cost-effective nano- and micro-biotechnology strategies to minimize the adverse impact of agrochemicals and pesticide residues on soil microbiota, soil fertility, and their biomagnification in food crops. Nano-bioinoculants - the combination of nano-compounds and bioinoculants - have been increasingly used as soil amendments. They can improve agri-potential and soil health by maintaining soil physico- and biological properties, microbial diversity, and the nutrient-solubilizing microbial population. They also aid in improving crop yields and reducing agrochemical and pesticide residues. Nano-bioinoculants are more efficient than other methods for removing contaminants due to their small size, high reactivity, and catalytic activities. Several types of nano-compounds (chitosan, zeolite, gypsum, and silicon dioxide) have been used in conjunction with beneficial microbes (bacteria fungi, actinomycetes & endophytic bacteria) as nano-bioinoculants.