Chemopotentiation by Hyperthermia

Chemopotentiation by Hyperthermia
Author: M. Urano
Publisher: VSP
Total Pages: 368
Release: 1994-04
Genre: Science
ISBN: 9789067641661

The number of studies on the use of hyperthermia in combination with chemotherapeutic agents is steadily increasing. However, thermochemotherapy has not yet captured significant clinical interest. Therefore, this fourth volume in the book series Hyperthermia and Oncology deals with this topic, as the editors feel there is a significant potential for this combined modality as an adjuvant to palliative or definitive radiotherapy, or the use of chemotherapy alone to treat localized or advanced diseases. The articles in this volume deal with various aspects of chemotherapy combined with hyperthermia and will be of value and interest to researchers in this field.

Locoregional High-Frequency Hyperthermia and Temperature Measurement

Locoregional High-Frequency Hyperthermia and Temperature Measurement
Author: G. Bruggmoser
Publisher: Springer Science & Business Media
Total Pages: 153
Release: 2012-12-06
Genre: Medical
ISBN: 3642825303

The present challenge in the treatment of tumors is to reduce the number of patients that still die as a result of primary tumors. Today, the percentage of such deaths remains high at 30%, even when all the common therapeutic methods, namely surgery, radiotherapy, and chemotherapy, are applied. In order to reduce this percentage, new types of radiation sources with a higher linear energy transfer have been intro duced, such as neutrons and pions. Fractionation patterns have been modified and radiosensitizers have been applied to in crease biological efficiency. Studies of the combined application of chemotherapy and radiotherapy have been made to find the best therapeutic effect. In the early 1970s biological findings confirmed the effect of hyperthermia on tumor cells. The first clinical studies on hyper thermia treatment demonstrated that it resulted in better local tumor control. Further application of this treatment modality showed that hyperthermia should be used in addition to radio therapy and chemotherapy. Despite these encouraging results, hyperthermia has not been introduced into common clinical use, due primarily to technical problems. There are a number of methods of transferring heat into tumors; however, with regard to physical conditions, an op timum method has not yet been found. One of the reasons is that up to now we have had no reliable method of obtaining thermal mapping of all parts of the human body. Such measurements are required not only for dosimetric purposes but also for the regula tion of a hyperthermic system.

Biological Basis of Oncologic Thermotherapy

Biological Basis of Oncologic Thermotherapy
Author: Michel Gautherie
Publisher: Springer Science & Business Media
Total Pages: 466
Release: 2012-12-06
Genre: Medical
ISBN: 3642749399

Studies on the effects of hyperthermia have aroused great interest in recent years. On the one hand, it has been demonstrated. that hyperthermia may be a useful treatment modality for tumors, in combination with ionizing radia tion or cytotoxic drugs. On the other hand, it is of great scientific interest to study the effects of increased temperature on biological systems. Although hyperthermia has been used in the treatment of cancer for cen turies, its therapeutic success was doubtful. However, since it has been shown that radiation-induced cell killirtg can be remarkably enhanced by hyperthermia, many investigations have been performed with cells in vitro, tumors in situ, and normal tissues. From these studies it has been concluded that many biological phenomena and their characteristics which are found in tumors may be conducive to the use of hyperthermia in cancer therapy. Many researchers are studying the cell-killing mechanisms of heat and fac tors that modify cell thermosensitivity. A very fascinating biological phenomenon is the general observation that living cells can enhance their thermoresistance within hours of heat treatment. The development of such thermotolerance is apparently a universal process, and its mechanism is of general scientific interest. Metabolic and physiological processes are changed during and after hyperthermic treatment. These changes exert a strong feedback on the thermo sensitivity of cells and tissues, and also in fluence the heating characteristics of tissues, especially in tumors.

Thermoradiotherapy and Thermochemotherapy

Thermoradiotherapy and Thermochemotherapy
Author: M.Heinrich Seegenschmiedt
Publisher: Springer Science & Business Media
Total Pages: 415
Release: 2012-12-06
Genre: Medical
ISBN: 3642609384

Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy of ionizing radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Triple modality (thermo-chemo-radiotherapy) or other treatment combinations have not been fully evaluated and may demonstrate extended clinical applications in the future. Problems remain with regard to maximizing the effects of hyperthermia as they are influenced by a variety of external and intrinsic factors including bloodflow, microenvironment etc. While the previous volume has summarized more theoretical aspects of hyper thermia, i.e. biology, physiology and physics, the present volume compiles the current knowledge relative to the clinical applications of hyperthermia in combina tion with radiation therapy and/or chemotherapy, providing a comprehensive over view of its use in cancer management.

Challenges and Solutions of Oncological Hyperthermia

Challenges and Solutions of Oncological Hyperthermia
Author: Andras Szasz
Publisher: Cambridge Scholars Publishing
Total Pages: 456
Release: 2020-04-02
Genre: Medical
ISBN: 1527549135

The next generation of oncological hyperthermia involves the medical innovation of selectively heating up the malignant cells of the body in a controlled way. The easily-distinguishable biophysical and physiological characteristics of cancer cells and their immediate environment are the focus of the targeted energy delivery of this treatment. This heterogenic heating concept breaks with the homogeneous nature of conventional hyperthermia, where an isothermally equal temperature is applied to the large surface area of a solid tumor. Due to its selectivity, the new concept enables the usage of a significantly lower energy, making it safer, less toxic, and easier to use. This book shows the challenges facing oncological hyperthermia, and highlights clinical results obtained in various countries. It also presents discussions about the theoretical basis of the method, adding some technical discussions and clarifying the most difficult points of its design. The contributions dealing with clinical results use state-of-art conventional therapies with complementary hyperthermia and show the advantages of such a combination.

Hyperthermia

Hyperthermia
Author: D. J. Watmough
Publisher:
Total Pages: 264
Release: 1986
Genre: Medical
ISBN:

Oncothermia: Principles and Practices

Oncothermia: Principles and Practices
Author: Andras Szasz
Publisher: Springer Science & Business Media
Total Pages: 575
Release: 2010-11-23
Genre: Medical
ISBN: 9048194989

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.