Chemical Engineering in the Pharmaceutical Industry

Chemical Engineering in the Pharmaceutical Industry
Author: David J. am Ende
Publisher: John Wiley & Sons
Total Pages: 1431
Release: 2011-03-10
Genre: Technology & Engineering
ISBN: 1118088107

This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.

Green Chemistry and Engineering

Green Chemistry and Engineering
Author: Concepción Jiménez-González
Publisher: John Wiley & Sons
Total Pages: 615
Release: 2011-04-12
Genre: Science
ISBN: 1118101979

The past, present, and future of green chemistry and green engineering From college campuses to corporations, the past decade witnessed a rapidly growing interest in understanding sustainable chemistry and engineering. Green Chemistry and Engineering: A Practical Design Approach integrates the two disciplines into a single study tool for students and a practical guide for working chemists and engineers. In Green Chemistry and Engineering, the authors—each highly experienced in implementing green chemistry and engineering programs in industrial settings—provide the bottom-line thinking required to not only bring sustainable chemistry and engineering closer together, but to also move business towards more sustainable practices and products. Detailing an integrated, systems-oriented approach that bridges both chemical syntheses and manufacturing processes, this invaluable reference covers: Green chemistry and green engineering in the movement towards sustainability Designing greener, safer chemical synthesis Designing greener, safer chemical manufacturing processes Looking beyond current processes to a lifecycle thinking perspective Trends in chemical processing that may lead to more sustainable practices The authors also provide real-world examples and exercises to promote further thought and discussion. The EPA defines green chemistry as the design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Green engineering is described as the design, commercialization, and use of products and processes that are feasible and economical while minimizing both the generation of pollution at the source and the risk to human health and the environment. While there is no shortage of books on either discipline, Green Chemistry and Engineering is the first to truly integrate the two.

Engineering Chemistry

Engineering Chemistry
Author: Shikha Agarwal
Publisher: Cambridge University Press
Total Pages: 1343
Release: 2019-05-23
Genre: Science
ISBN: 1108724442

Written in lucid language, the book offers a detailed treatment of fundamental concepts of chemistry and its engineering applications.

Beyond the Molecular Frontier

Beyond the Molecular Frontier
Author: National Research Council
Publisher: National Academies Press
Total Pages: 238
Release: 2003-03-19
Genre: Science
ISBN: 0309168392

Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.

Chemistry For Engineers

Chemistry For Engineers
Author: Teh Fu Yen
Publisher: World Scientific
Total Pages: 575
Release: 2008-01-02
Genre: Science
ISBN: 1911298410

Engineering requires applied science, and chemistry is the center of all science. The more chemistry an engineer understands, the more beneficial it is. In the future, global problems and issues will require an in-depth understanding of chemistry to have a global solution.This book aims at bridging the concepts and theory of chemistry with examples from fields of practical application, thus reinforcing the connection between science and engineering. It deals with the basic principles of various branches of chemistry, namely, physical chemistry, inorganic chemistry, organic chemistry, analytical chemistry, surface chemistry, biochemistry, geochemistry, fuel chemistry, polymer chemistry, cement chemistry, materials chemistry, and asphalt chemistry. Written primarily for use as a textbook for a university-level course, the topics covered here provide the fundamental tools necessary for an accomplished engineer./a

Molecular Physical Chemistry for Engineers

Molecular Physical Chemistry for Engineers
Author: John T. Yates
Publisher: University Science Books
Total Pages: 508
Release: 2007-08-31
Genre: Science
ISBN: 9781891389276

Designed as a one-semester undergraduate course for engineers and materials scientists who need to understand physical chemistry, this book emphasises the behaviour of material from the molecular point of view.

Chemistry for Engineering Students

Chemistry for Engineering Students
Author: Lawrence Stephen Brown
Publisher: Brooks Cole
Total Pages: 510
Release: 2014
Genre: Science
ISBN: 9781285462523

Reflecting Cengage Learning's commitment to offering flexible teaching solutions and value, this new hybrid version features the instructional presentation found in the printed text while delivering all the end-of chapter exercises online in OWLv2, the leading online learning system for chemistry. The result--a briefer printed text that engages students online! An access code to OWLv2 with MindTap Reader, is included with the text, providing learners with powerful online resources that include tutorials, simulations, randomized homework questions, videos, a complete interactive electronic version of the textbook, and more! Enhanced with a remarkable number of new problems and applications, the Third Edition of CHEMISTRY FOR ENGINEERING STUDENTS provides a concise, thorough, and relevant introduction to chemistry that prepares learners for further study in any engineering field. Updated with even more questions and applications specifically geared toward engineering, the book emphasizes the connection between molecular properties and observable physical properties and the connections between chemistry and other subjects such as mathematics and physics. This new edition is now fully supported by OWL, the most widely-used online learning system for chemistry.

General Chemistry for Engineers

General Chemistry for Engineers
Author: Paul DiMilla
Publisher: Cognella Academic Publishing
Total Pages: 282
Release: 2013
Genre:
ISBN: 9781609270803

General Chemistry for Engineers is tailored for a one-semester freshman-level college course for students pursuing engineering degrees. The book offers a balance of conciseness, rigor, and depth needed to prepare students for more advanced coursework and careers in various engineering specialties, such as civil, environmental, electrical, computer, mechanical and industrial engineering, in addition to chemical engineering. This text leads students through the breadth of a typical two-semester sequence in general chemistry. It elucidates the key concepts and skills important for entering engineering students, including problem solving, qualitative and quantitative thinking, and importance of units. Examples are drawn from problems of interest to modern engineers, including alternative energy, advanced materials, and the environment. The book is the result of the author's unique experiences teaching approximately 2,500 freshman in chemistry and upper-level students in chemical and biological engineering, in addition to leading research and development teaching in the medical device and specialty pharmaceutical industries. The author received a variety of teaching awards at Northeastern honoring his work in making an intense, fast-pace course manageable and exciting.

Chemical Engineering in the Pharmaceutical Industry

Chemical Engineering in the Pharmaceutical Industry
Author: David J. am Ende
Publisher: John Wiley & Sons
Total Pages: 1172
Release: 2019-04-23
Genre: Technology & Engineering
ISBN: 1119285860

A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying Presents updated and expanded example calculations Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industryf ocuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.

Pharmaceutical Process Development

Pharmaceutical Process Development
Author: John Blacker
Publisher: Royal Society of Chemistry
Total Pages: 375
Release: 2011-08-17
Genre: Science
ISBN: 1849733074

Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation. The book ends with an assessment of future trends and challenges. The book provides a valuable overview of: both early and late stage chemical development, how safe and scaleable synthetic routes are designed, selected and developed, the importance of the chemical engineering, analytical and manufacturing interfaces, the key enabling technologies, including catalysis and biocatalysis, the importance of the green chemical perspective and solid form issues. The book, written and edited by experts in the field, is a contemporary, holistic treatise, with a logical sequence for process development and mini-case histories within the chapters to bring alive different aspects of the process. It is completely pharmaceutical themed, encompassing all essential aspects, from route and reagent selection to manufacture of the active compound. The book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry. It informs them about the breadth of the work carried out in chemical research and development departments, and gives them a feel for the challenges involved in the job. The book is also of value to academics who often understand the drug discovery arena, but have far less appreciation of the drug development area, and are thus unable to advise their students about the relative merits of careers in chemical development versus discovery.